Gene ACP5-1 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PAP
Subfamily ACP5
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP110_AA protein Get Run
NvecP110_AA_9-216 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PAPL_pd Subfamily PAPL 11-217 1.1e-87 284.6 In-house 1-212 (212) alignment 
Range on Protein: 11-217
Range on HMM: 1-212/212.0
LAVGDTGGTPLSPFFTPTERRVATVMGKVAEEVDARFVLGLGDNFYFSGVRNARDPRFRLSFEDVFSAPALhRATWCMIAGNHDYQGNVSAQIAYTQKSR
|..||.||.. .|..|.....||...||||||..|.||| ||||||..||.. .|.||. .|||||.|..| ...|...||||||.|||||||||...|.
lvlgDwGgleeapyttaaqeavakelgkvaeeleaqfvlalGDnfYekGvkdvddarfketfedvftaesl.qvpwyvvagnHDykGnvsaqiaYsklsk

RWYFPNFYYTFVGTIPKSRSTVQVVMIDTMLLCFKKYRNKsPSLLVNLFNKYINFFFI-------RANYLIVAGHHPVFSVGPHGSTKCLRSRLVPLLRK
||.||..|||   .||.|..|||.|.|||.|||.|. ..| ..  |.. ..  .. ..       .|.|||||||.||.||. ||.||.|..|| |||.|
rWkfpslyytksfkipdsnatvqlvlidtvllcgksddlk.legpvdvslaeeqwawleeeLkaseadylivaGhypvwsvaehGptkiLvkrLkPlLek

YKVSAYLSGHDHNL
|.|.||||||||||
ynvtaylsGhDhnl
ACP5 10-216 2.6e-59 192.2 In-house 1-198 (198) alignment 
Range on Protein: 10-216
Range on HMM: 1-198/198.0
FLAVGDTGGTPLSPFftpteRRVATVMGKVAEEVDARFVLGLGDNFYFSGVRNARDPRFRLSFEDVFSAPALHrATWCMIAGNHDYQGNVSAQIAYTQKS
||.||| |... ...     ..||. ||||||. |..||| ||||||..|| ...||||. |||....|..|.   |....|||||.|||||||.|...|
flvvGDwGrkgeynq.....savakqmgkvaekldidfvlslGDnfyddGvtsvddprfkesfekiytakslq.vpWyvvlGNHDyrgnvsaqieyakrs

RRWYFPNFYYTFVGTIpksrSTVQVVMIDTMLLCFKKYRNKSPSLLVNLFNKY-INFFFIRANYLIVAGHHPVFSVGPHGSTKCLRSRLVPLLRKYKVSA
... ||...|... ..     ...... .      ....... .   .. ..   ..   .|...||.|||||.|.| ||.||.| .|| |||.||||.|
kdsrfpslryslskke....vvtelftekkdeksdqrevaerekyaeeqlkwlekalakstadwkiVvGHhpvySigehgdtkelverllpllkkykvda

YLSGHDHN
||.||||.
YlnGHdHc
Metallophos Calcineurin-like phosphoesterase 9-216 1.3e-18 61.0 Pfam-A 2-199 (200) alignment 
Range on Protein: 9-216
Range on HMM: 2-199/200.0
SFLAVGDTGGTPLSPFftpteRrVATVMGKVAEEVDARFVLGLGDNFYFSGVRNARDPRFRlsfedVFSAPALHRATWCMIAGNHDYQGNVSAQIAYTQK
 .|..||..|..  .      . ..  . |.|.| .. .|| |||...     .    ...      .. . |    . .. |||.. .  ||  ..  .
rilvigDlHgglddle.....d.lllillkiaaeekpdlvlflGDlvdrgdwssetlalld.....ylvlklllpipvfllrGNHesdpgnsaygflleq

SRRWYFPNFYYTFVGTIPksrSTVQVVMIDTMLLCFKKYRNKSPSLLVNLFNKYINFFFIRANYLIVAGHHPVFSVGPHGS----TKCLRSRLVPLLRKY
..... .....   .. .    |      ..  |  ...... .    .|. .. .  .  ... |. .|.|..| | .|     . . .  | .||.||
lkdlrglangeeeyenlk...itllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddigselfgpdaleklleky

KVSAYLSGHDHN
.| ..|.||.| 
gvdlvlrGHtHk
PAPL 33-216 2.3e-12 39.5 In-house 14-193 (194) alignment 
Range on Protein: 33-216
Range on HMM: 14-193/194.0
ATVMGKVAEEVDARFVLGLGDNFYFSGVRNARDPRFRLSFedvfSAPALHRATWCMIAGNHDYQGNVSAQIAYTQKSRRWYFPNFYYTFVGT-IPKSRST
.. . | ... .  ..| .||  |  .  |..|    .       .|   .  . ...|||... | |.. |..... ... .. .. .  . .  . ..
lkrlqketqkgkydailhvGDlaYaddeqnewdgdefmrq....ieplaasvpymvapGNHEeeynfsnykarfsmpgseegesnssesgsnsysfetes

VQVVMIDTmLLCFKKYRNKSPSLLVNLFNKYINfffiRANYLIVAGHHPVFSVGPHG----STKCLRSRLVPLLRKYKVSAYLSGHDHN
| .... .    .|.. ..   |  .| ..  .    .  ..||.|| |...   .     ...  .. | .|| ||.|  .|.|| |.
vhfivlss.eedvkekseqyewleedlakvnRs....ktPWiivmgHrpmYcsnkdkddckekakmlaaledllykygVDlvlaGHeHs
subfamily_ACP5_pd Subfamily ACP5 42-216 6.4e-09 28.0 In-house 22-187 (189) alignment 
Range on Protein: 42-216
Range on HMM: 22-187/189.0
EVDARFVLGLGDNFYFSGVRNardPRFRLSFEDVFSaPALHRATWCMIAGNHDYQGNVSAQiaytqkSRRWYFP--NFYYTFvgtipkSRSTVQVVMIDT
. ...... .||  |  . .|    .   .| .... |   .  . ...|||... |.||       ..|.  |  | .|.|          |......|
aneldliihvGDlaYalkakn...eavwdefmnlie.plaskvPymvsiGnhesdsnfsay......kkrfsmpsknewYsf......dygpvhfislst

MLLCFKKyrNKSPSLLVNLFNKYiNfFFIRANYLIVAGHHPVFSVGPHGS-----TKCL----RSRLVPLLRKYKVSAYLSGHDHN
.   ...  ..  . | .  ... |      ...||.||.|..    ...     ....    |..| .|| ||||  .||||.|.
evdfslg..seqykWLekdLkea.n.nrkktpwiivmgHrPmYcsnkdeddctkeetlvrkglresledllykykvdlalsgHeHs
Metallophos_2 Calcineurin-like phosphoesterase superfamily domain 36-227 9.5e-07 20.9 Pfam-A 20-131 (156) alignment 
Range on Protein: 36-227
Range on HMM: 20-131/156.0
MGKVaEEvdARFVLGLGDnfyfsgvrnardprfrlSFEDVFSAPALHRATWCMIAGNHDYQGnVSAQIAYTQksrrwyfpnfyytfvgtipksrstvqvv
. .. .|  ....| .||                 ..|     . | ..  ... ||||..  . ...| .                             
ledi.ke..vdlilhaGD.................lvepeevvelledipvlavrGnhDeae.lpkelavel............................

midtmllcfkkyrnkspsllvnlFNKYINFFFIRANYLIVAGHHPVFSvgphgstkCLRSRLVPLLRKYKVSAYLSGHDHNLQHIKATDSTV
                       .... .. . . . |.| |.   .           ...|  ||..........|| |. .  | .. .|
.......................llaaaaleiegdrvllvhgtplsvq........sseeelaellkeagadlvflGHtHkpkvekrggtlv
BID BH3 interacting domain (BID) 123-172 4.9e-06 12.4 Pfam-A 138-184 (196) alignment 
Range on Protein: 123-172
Range on HMM: 138-184/196.0
GTIPKSRSTVQVVMIDTMLLCfKKYRNKSPSLLVNLFNKYINFffIRANY
 |.|.     ..... ..||  ||  ...|||| ..|.  .||  |  |.
qtvPsdveqekamlvlallLa.kkvaehaPsLLrdvfrttvnf..inqnl