Gene ACP5-2 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PAP
Subfamily ACP5
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP111_AA protein Get Run
NvecP111_AA_6-209 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PAPL_pd Subfamily PAPL 8-210 2.5e-91 296.6 In-house 1-212 (212) alignment 
Range on Protein: 8-210
Range on HMM: 1-212/212.0
LAIGDFGGKAWPPYYTGTLKNVAKTMGKVARTKSARFVLGLGDNFYWNGVKNVNDFRFQSTFENVFNAPALhKTTWHMIAGNHDYLGNVLAQIAYTKVSR
|..||.||... ||.| . ..|||..||||.. .|.||| ||||||..|||.|.| ||..|||.||.|..| ...|...|||||| ||| |||||.|.|.
lvlgDwGgleeapyttaaqeavakelgkvaeeleaqfvlalGDnfYekGvkdvddarfketfedvftaesl.qvpwyvvagnHDykGnvsaqiaYsklsk

RWNFPNYYYTKVERIPGTCVTVQVVMIDTTLLCYKRTS----------ERIAHYKWLEETLKNSSADYLVVAGHHPVYSAGVHGSTYCLQQKLRPLLWAY
||.||..||||  .||....|||.|.|||.|||.|...           . ....||||.||.|.||||.||||.||.|.. ||.| .|...|.|||. |
rWkfpslyytksfkipdsnatvqlvlidtvllcgksddlklegpvdvslaeeqwawleeeLkaseadylivaGhypvwsvaehGptkiLvkrLkPlLeky

DVTAYLSGHDHNL
.||||||||||||
nvtaylsGhDhnl
ACP5 7-209 4.5e-67 217.5 In-house 1-198 (198) alignment 
Range on Protein: 7-209
Range on HMM: 1-198/198.0
FLAIGDFGGKAWPPYytgtlKNVAKTMGKVARTKSARFVLGLGDNFYWNGVKNVNDFRFQSTFENVFNAPALHKtTWHMIAGNHDYLGNVLAQIAYTKVS
||..||.|.|  ...     ..|||.|||||......||| |||||| .||..|.| ||...||....|..|..  |....|||||.||| |||.|.| |
flvvGDwGrkgeynq.....savakqmgkvaekldidfvlslGDnfyddGvtsvddprfkesfekiytakslqv.pWyvvlGNHDyrgnvsaqieyakrs

RRWNFPNYYYTKVERI-PGTCVTVQVVMIDTTLLCYKRTSERIAHYKWLEETLKNSSADYLVVAGHHPVYSAGVHGSTYCLQQKLRPLLWAYDVTAYLSG
....||...|......   ...| .  . . .    .|....    ||||..|..|.||...|.|||||||.| ||.| .|...|.||| .|.|.|||.|
kdsrfpslryslskkevvtelftekkdeksdqrevaerekyaeeqlkwlekalakstadwkiVvGHhpvySigehgdtkelverllpllkkykvdaYlnG

HDHN
|||.
HdHc
Metallophos Calcineurin-like phosphoesterase 7-209 6.6e-19 62.0 Pfam-A 3-199 (200) alignment 
Range on Protein: 7-209
Range on HMM: 3-199/200.0
FLAIGDFGGKAWPPYytgtlKnVAKTMGKVARTKSARFVLGLGDNFYWNGVKNVNDFRFQstfenVFNAPALHKTTWHMIAGNHDYLGNVLAQIAYTKVS
.|.||| .|. . ..     . ..  . |.|    . .|| |||... .   .    ...      .  . | .. .... |||.. .   |  .. ...
ilvigDlHgglddle.....d.lllillkiaaeekpdlvlflGDlvdrgdwssetlalld.....ylvlklllpipvfllrGNHesdpgnsaygflleql

RRWNFPNYYYTKVERIPgTCVTVQVVMIDTTLLCYKRTSERIAHYKWLEETLKN--SSADYLVVAGHHPVYSAGVHGS----TYCLQQKLRPLLWAYDVT
.... ..... . |  . .  .   . . . .  |...  ... . . |. ...  . .|. .. .|.|..| | .|     ...  . |..||  |.|.
kdlrglangeeeyenlk.itllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddigselfgpdalekllekygvd

AYLSGHDHN
..|.||.| 
lvlrGHtHk
PAPL 10-209 7.4e-17 54.1 In-house 3-193 (194) alignment 
Range on Protein: 10-209
Range on HMM: 3-193/194.0
IGDFGGKAWPPyytgtlknvAKTMGKVARTKSARFVLGLGDNFYWNGVKNVNDFRF-QSTFEnvfnaPALHKTTWHMIAGNHDYLGNVLAQIAYTKVSRR
.||.| . .           .|.. | .....  ..| .||  |  . .| .|        |     |   .. . ...|||..  |  .. |... . .
fGDlGqtnass.........lkrlqketqkgkydailhvGDlaYaddeqnewdgdefmrqie.....plaasvpymvapGNHEeeynfsnykarfsmpgs

WNFPNYYYTKVERIPGTCVTVQVVMIDTTllcYKRTSERIAHYKWLEETLKN---SSADYLVVAGHHPVYSAGVHGS----TYCLQQKLRPLLWAYDVTA
.. ..... . .      .......  ..   .. ..|.  .|.|||| |..   |  ....|.|| |.|.   . .    .   ...| .|| .| |  
eegesnssesgsnsysfetesvhfivlss...eedvkekseqyewleedlakvnRsktPWiivmgHrpmYcsnkdkddckekakmlaaledllykygVDl

YLSGHDHN
.|.|| |.
vlaGHeHs
subfamily_ACP5_pd Subfamily ACP5 30-209 3.3e-14 45.2 In-house 13-187 (189) alignment 
Range on Protein: 30-209
Range on HMM: 13-187/189.0
AKTMGKVARTKSARFVLGLGDNFYWNGVknvNDFRFQSTFENVFNaPALHKTTWHMIAGNHDYLGnvlaqiAYTKVSRRWNFPnyyyTKVERIPGTCVTV
..|  | .......... .||  |  .    .. .   .| |... |   |. . ...|||..         ......|.. |    .| |     .  |
latllkeeeaneldliihvGDlaYalka...kneavwdefmnlie.plaskvPymvsiGnhesds......nfsaykkrfsmp....sknewYsfdygpv

QVVMIDTTLLCYKRtserIAHYKWLEETLKNS----SADYLVVAGHHPVYSAGVHGSTY-----CLQ----QKLRPLLWAYDVTAYLSGHDHN
......|    ..        |||||. ||.     . ....|.||.|.|    ... .     ...    ..| .||  |.|  .||||.|.
hfislstevdfslg....seqykWLekdLkeannrkktpwiivmgHrPmYcsnkdeddctkeetlvrkglresledllykykvdlalsgHeHs
Metallophos_2 Calcineurin-like phosphoesterase superfamily domain 36-231 1.4e-07 23.6 Pfam-A 23-140 (156) alignment 
Range on Protein: 36-231
Range on HMM: 23-140/156.0
VartKSARFVLGLGDnfywngvknvndfrF--QstfENVfnAPALHKTTWHMIAGNHDylgnvlaqiaytkvsrR----------Wnfpnyyytkverip
.   |.....| .||              .  .   | |   . | ..  ... ||||                .                         
i...kevdlilhaGD..............lvep...eev..velledipvlavrGnhD................eaelpkelavel..............

gtcvtvqvvmidttllcykrtseriahykwleetlknS----------SadylvvaghhpvYSAGVHGSTYCL---QQKLRPLLWAYDVTAYLSGHDHNL
                                                                 |||. . .   ...|. || .... ....|| |. 
.....................................llaaaaleiegd............rvllvhgtplsvqsseeelaellkeagadlvflGHtHkp

QHIKEKNydVHYFVSGSASNH
.  |...  ..... ||. ..
kvekrgg..tlvvnpGsvgep