Gene ACP5-3 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PAP
Subfamily ACP5
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP112_AA protein Get Run
NvecP112_AA_26-239 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PAPL_pd Subfamily PAPL 28-240 1.5e-106 346.4 In-house 1-212 (212) alignment 
Range on Protein: 28-240
Range on HMM: 1-212/212.0
LAVGDWGGLEFLPYKTPVESSVANRMGKVADTIHAQFVVALGDNFYFHGVKDVDDKRFQETYEDVFTAKSLMVPWYVCAGNHDHYGNASAEIAYSQRSKR
|..|||||||  ||.|. ...||...||||....||||.|||||||..|||||||.||.||.||||||.||.|||||.|||||..||.||.||||. |||
lvlgDwGgleeapyttaaqeavakelgkvaeeleaqfvlalGDnfYekGvkdvddarfketfedvftaeslqvpwyvvagnHDykGnvsaqiaYsklskr

WNFPDFYYTRSWNIPGTSQEVQLVLLDTVLLCGNTKAdHVLDRPQSPSAAEAQWQWLEKTLKESQAHYLLVGGHFPVWSIAEHGPTRCLVDRLKPLLEKY
|.||..|||.|..||.....|||||.|||||||.... ..|..|.. |.||.||.|||..||.|.|.||.|.||.||||.||||||..||.|||||||||
Wkfpslyytksfkipdsnatvqlvlidtvllcgksdd.lklegpvdvslaeeqwawleeeLkaseadylivaGhypvwsvaehGptkiLvkrLkPlLeky

RVNAYLSGHDHNL
.|.||||||||||
nvtaylsGhDhnl
ACP5 27-239 1.1e-73 239.1 In-house 1-198 (198) alignment 
Range on Protein: 27-239
Range on HMM: 1-198/198.0
FLAVGDWGGLEFLPYKtpvesSVANRMGKVADTIHAQFVVALGDNFYFHGVKDVDDKRFQETYEDVFTAKSLMVPWYVCAGNHDHYGNASAEIAYSQRSK
||.|||||. .  ...     .||. |||||.. ...||..||||||..||..|||.||.|..|...||||| |||||..||||..||.||.|.|..|||
flvvGDwGrkgeynqs.....avakqmgkvaekldidfvlslGDnfyddGvtsvddprfkesfekiytakslqvpWyvvlGNHDyrgnvsaqieyakrsk

RWNFPDFYYTRSWNIpgtsqevqlvLLDTVLLCGNTKADHVLDRPQSPSAAEAQWQWLEKTLKESQAHYLLVGGHFPVWSIAEHGPTRCLVDRLKPLLEK
...|| ..|. | ..            ...  . ... ..   .... ..|| |..||||.|..|.| ...| ||.||.||.|||.|..||.||.|||.|
dsrfpslryslskke..........vvtelftekkdeksdqrevaerekyaeeqlkwlekalakstadwkiVvGHhpvySigehgdtkelverllpllkk

YRVNAYLSGHDHN
|.|.|||.||||.
ykvdaYlnGHdHc
Metallophos Calcineurin-like phosphoesterase 26-239 1.8e-21 70.3 Pfam-A 2-199 (200) alignment 
Range on Protein: 26-239
Range on HMM: 2-199/200.0
RFLAVGDWGGLEFLPYktpveSsVANRMGKVADTIHAQFVVALGDNFYFHGVKDVDDKRFQetyeDVFTAKSLMVPWYVCAGNHDHYGNASAEIAYSQRS
|.|..||..|    ..       ..... |.|    ...|. |||...     .   ....          .| .|.... |||. .. .||  ..  ..
rilvigDlHgglddle.....d.lllillkiaaeekpdlvlflGDlvdrgdwssetlalld....ylvlklllpipvfllrGNHesdpgnsaygflleql

KRWNFPDFYYTRSWNIpgtsqevqLvlLDTVLLCGNTKADHVLDRPQSPSAAEAQWQWLEKTLKESQAHYLLVGGHFPVWSIAEHGPT----RCLVDRLK
|... .....   .|         .     .   | .   . |     .||.|.|.....  ...... . .. .| |..|  ..| .     .  | | 
kdlrglangeeeyenl........k..itllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddigselfgpdale

PLLEKYRVNAYLSGHDHN
.|||||.| ..|.||.| 
kllekygvdlvlrGHtHk
subfamily_ACP5_pd Subfamily ACP5 55-239 1.8e-17 55.9 In-house 18-187 (189) alignment 
Range on Protein: 55-239
Range on HMM: 18-187/189.0
KVADTIHAQFVVALGDNFYFHGVkdvDDKRFQETYEDVFTAKSLMVPWYVCAGNHDHYGnasaeiAYSQRSKRWNFPdfyYTRSWNIPGtSQEVQLVLLD
| ... ...... .||  | ..    ....  ... ...   .  ||. |..|||..         .|...||.. |      .|      ..|... |.
keeeaneldliihvGDlaYalka...kneavwdefmnlieplaskvPymvsiGnhesds......nfsaykkrfsmp...sknewYsfd.ygpvhfisls

TVLLCGNTkadhvldrpqspsaaEAQWQWLEKTLKES----QAHYLLVGGHFPVWSIAEHGpTRC----------LVDRLKPLLEKYRVNAYLSGHDHN
|     .                . |..|||| |||     .  ...| || |..   ...  .|          |...| .||.||.|. .||||.|.
tevdfslg...............seqykWLekdLkeannrkktpwiivmgHrPmYcsnkde.ddctkeetlvrkglresledllykykvdlalsgHeHs
PAPL 50-239 7e-13 41.1 In-house 14-193 (194) alignment 
Range on Protein: 50-239
Range on HMM: 14-193/194.0
ANRMGKVADTIHAQFVVALGDNFYFHGVKDVDDKRF-QETYEDVFTAkslmVPWYVCAGNHDHYGNASAEIAYSQRSKRWNFPDFYYTRSWNIPGTSQEV
..|. | ... . .... .||  |  . ..  |.    .  | ...     ||. |..|||..  | |.. |......... .  ..  ..|    ..|.
lkrlqketqkgkydailhvGDlaYaddeqnewdgdefmrqieplaas....vpymvapGNHEeeynfsnykarfsmpgseegesnssesgsnsysfetes

QLVLldtvllcgntkadhVLDRPQSPSAAEAQWQWLEKTLK---ESQAHYLLVGGHFPVWSIAEHGP----TRCLVDRLKPLLEKYRVNAYLSGHDHN
. ..              ||   .. .  . |..|||. |.    |.  .. | || |...  ..      ..  .. |..|| ||.|. .|.|| |.
vhfi..............vlsseedvkekseqyewleedlakvnRsktPWiivmgHrpmYcsnkdkddckekakmlaaledllykygVDlvlaGHeHs
Metallophos_2 Calcineurin-like phosphoesterase superfamily domain 61-249 1.2e-06 20.6 Pfam-A 25-130 (156) alignment 
Range on Protein: 61-249
Range on HMM: 25-130/156.0
HAQFVVALGDnfyfhgvkD--VddkrfqetyEDVFTAKSLMvPWYVCAGNHDhygnasaeiayS----------Qrskrwnfpdfyytrswnipgtsqev
 ..... .||                     | |.   . . | ... ||||                                                
evdlilhaGD........lvep.........eevvelledi.pvlavrGnhD...........eaelpkelavel.........................

qlvllD-----------TVLLCGNTKADhvldrpqspsaaeaqwqwlektlkesqahyllvgghfpvwsiaehgptrC--LVDRLKPLLEKYRVNAYLSG
                 .|||. .|...                                                 .    ..|. ||..........|
.....llaaaaleiegdrvllvhgtpls.................................................vqsseeelaellkeagadlvflG

HDHNLQHLKEANST
| |. .  |. . .
HtHkpkvekrggtl