Gene PPP4C in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP4C
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP119_AA protein Get Run
NvecP119_AA_3-294 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP4C_pd Subfamily PPP4C 5-292 1e-184 605.4 In-house 1-288 (288) alignment 
Range on Protein: 5-292
Range on HMM: 1-288/288.0
SDLDRQIEKLRNCELITEKEVKQLCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRY
|||||||||||.||||.|.|||.|||||||||||||||||||||||||||||||||||.||||||||||.|||||.||||||||||||||||||||||||
sdldrqieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvry

PDRITLIRGNHESRQITQVYGFYDECLKKYGSITVWRYCAEIFDYLSLSAIIDNRVFCVHGGLSPSISTLDQIRSIDRKQEVPHDGPMCDLLWSDPEDIQ
|||||||||||||||||||||||||||.||||..|||||.|.||||||.||||...|||||||||||||||.||||||||||||.||.||||||||||..
pdritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedae

GWGVSPRGAGYLFGSDVVAQYNAANDIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLKREFTIFEAAPQD
||.|||||||||||||||.|.|.||||.||||||||||||||.||||.|||||||||||||||||||||||||.|...|.|||||...
gwavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaaaae
subfamily_PPP2C_pd Subfamily PPP2C 5-291 2.9e-156 512.0 In-house 2-288 (290) alignment 
Range on Protein: 5-291
Range on HMM: 2-288/290.0
SDLDRQIEKLRNCELITEKEVKQLCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRY
.|||..||||..|. ..|.|||.|| ||.||| .||||| | .|||||||.||||.|| ||||.||..|||||||.||.||||.|||||  || ||||||
kdldklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvry

PDRITLIRGNHESRQITQVYGFYDECLKKYGSITVWRYCAEIFDYLSLSAIIDNRVFCVHGGLSPSISTLDQIRSIDRKQEVPHDGPMCDLLWSDPEDIQ
..|||..||||||||||||||||||||.|||. .||.| ...||||.|.|..|...||.||||||||.|||.||..|| |||||.||.||||||||.| .
keritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrg

GWGVSPRGAGYLFGSDVVAQYNAANDIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLKREFTIFEAAPQ
|||.||||||| || |.  ..| .|.. || ||||||||||.| ... | |..||||||||||| |||||||..||..|  |..||.
gwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpapr
subfamily_PPP6C_pd Subfamily PPP6C 6-293 6.3e-153 501.0 In-house 1-288 (290) alignment 
Range on Protein: 6-293
Range on HMM: 1-288/290.0
DLDRQIEKLRNCELITEKEVKQLCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYP
.||. ||  ..|. ..|...|.||..  ..|.|||||| | ||||||||||||||||.|||. ||.||||.|.|.|||||||.||.||| .||.||..||
eldkwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakyp

DRITLIRGNHESRQITQVYGFYDECLKKYGSITVWRYCAEIFDYLSLSAIIDNRVFCVHGGLSPSISTLDQIRSIDRKQEVPHDGPMCDLLWSDPEDIQG
|||||.||||||||||||||||||||.|||. ..|.||...|| |...||||..|.|||||||| . |||||| |.| ||.||.|..|||.||||||.. 
dritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedvet

WGVSPRGAGYLFGSDVVAQYNAANDIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLKREFTIFEAAPQDV
| |||||||||||| |. .... |...|||||||||.||.|..|.| . ||||||||||||||||.||.|... .||. .|.| |.. 
wavsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfkavpdee
subfamily_PPG1_pd Subfamily PPG1 7-292 2.4e-135 443.6 In-house 1-299 (300) alignment 
Range on Protein: 7-292
Range on HMM: 1-299/300.0
LDRQIEKLRNCELITEKEVKQLCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPD
||. .|||...||. |  ||.|. | .|.||.||||... ||||| ||.||||||. |.||.||.||||||||.||.||||.|||||  ||..||.||| 
ldecleklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklryps

RITLIRGNHESRQITQVYGFYDECLKKY-GSITVWRYCAEIFDYLSLSAIIDNRVFCVHGGLSPSISTLDQIRSIDRKQEVPHDGPMCDLLWSDPE----
||||.|||||||||||||||| |||.|| |  .||.| .||||||.|.||||. ..|||||||||. ..|||. .|| .|||..| ..||||||||    
ritllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennn

------DIQG--WGVSPRGAGYLFGSDVVAQYNAANDIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLKREFTIFEAAPQD
      | .|  . ||.||||| .| ||| ..   ||.. | |||||..|||. .|.. . |||||||||||||| |.|||| |...| | ..|.||..
ptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeapes
0045823 Metallo-dependent phosphatases 4-294 8.2e-122 400.1 In-house 27-329 (473) alignment 
Range on Protein: 4-294
Range on HMM: 27-329/473.0
CSDLDRQIEKLRNCELITEKEVKQLCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVR
 .|||. || |....|..|.....|. .|.||| .|.|..... ...|.||||||..||..|..  |  |.....|.||.|||| .|.|...||||||..
lldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkik

YPDRITLIRGNHESRQITQVYGFYDECLKKYgSITVWRYCAEIFDYLSLSAIIDNRVFCVHGGLSPSISTLDQIRSIDRKQEVPHDGPMCDLLWSDPEDI
||....|.|||||.|.....|||.||.|.|| .. ..... | ...| |.|.|......|||||||....|||||.|.| .|.|.||...|||||||...
ypgnvfllrGNHElrllnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdPwed

QG--------WGVSPRGAGYLFGSDVVAQYNAANDIDLICRAHQLVMEGYKWHFNET------VLTVWSAPNYCYRCGNVAAILELDEHLkREFTIFEAA
 |        .| |||||||||| |.| .    |..|||.|.|. |.|||...|.        ..||.||||||.|.|| ||.|..||.| ..|..|...
dgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdps

PQDVR
|....
phpli
PPP_3 20-287 3.9e-121 396.2 In-house 2-270 (271) alignment 
Range on Protein: 20-287
Range on HMM: 2-270/271.0
ITEKEVKQLCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQ
..|.|.|.|. |..||| .|||......|||||||||||..|| ||||.||..|.|.|||.||.|||| .|.|..|||||||..||....|.||||||||
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

ITQVYGFYDECLKKYGSITVWRYCAEIFDYLSLSAIIDNRVFCVHGGLSPSISTLDQIRSIDRKQEVPHDGPMCDL-LWSDPEDIQGWGVSPRGAGYLFG
|..||||..|.|||.|. .|.... |.|..|.|.|.||..|..|||||||||..||||....||.|||..|...|| |.||||. .|.. |.||||.|||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

SDVVAQYNAANDIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLKREFTIFE
.||... . .|...||.|||.|..|||. .... |.||.||||||.|..|..|||.|.|.|..||...|
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
PPP_1 21-274 9.3e-114 372.1 In-house 2-263 (264) alignment 
Range on Protein: 21-274
Range on HMM: 2-263/264.0
TEKEVKQLCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQI
.|.|...|. |..|.|..|.|...|....||||||||||.|| .||||||..|.|||||.||.|||| .|||..|||||||..||....|.||||||||.
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

TQVYGFYDECLKKYGSITVWRYCAEIFDYLSLSAIIDNRVFCVHGGLSPSISTLDQIRSIDRKQEVPHDGPMCDL--------LWSDPEDIQGWGVSPRG
|.||||..|.|||..| .........||.|.|.|.||.....|||||||....||||| ..||.|||..|..|||        |..|.|. ...  |.||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

AGYLFGSDVVAQYNAANDIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILE
||||||.||..... .|...||.|||....|||.......|.|..||.||.....| .|...
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
0049330 Metallo-dependent phosphatases 5-292 2.7e-113 371.0 In-house 15-302 (309) alignment 
Range on Protein: 5-292
Range on HMM: 15-302/309.0
SDLDRQIEKLRNCELITEKEVKQLCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRY
|.||..||.|... |..|.|...|. ||.||| .|.|..... ...|.||||||..||..|..  | .|.....|.||.|||| .|.|..|||||||..|
slldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalklly

PDRITLIRGNHESRQITQVYGFYDECLKKYGsITVWRYCAEIFDYLSLSAIIDNRVFCVHGGLSPSISTLDQIRSIDRKQEVPHDGPMCDLLWSDPE-DI
||...|.|||||.|.....|||.||.| ||| . .|... . ...| | |.|.....||||||||.. .|||||...| .|.|.||..||||||||  ..
pdnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpir

QGWGVSPRGAGYLFGSDVVAQYNAANDIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLKREFTIFEAAPQD
 |.. .|||.|..|| ..| ..   |..|||.|.|..|..||...|.. ..||.||||||.|.||..|.||.||.|...|..||..|. 
egfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpll
0053225 Metallo-dependent phosphatases 5-290 4.3e-110 360.6 In-house 7-292 (293) alignment 
Range on Protein: 5-290
Range on HMM: 7-292/293.0
SDLDRQIEKLRNCELITEKEVKQLCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRY
..||..|| |... |..|.|...|. .|.|||..|.|..... ...|.|||||...||..|..  | .|.....|.||.|||| .|.|...||||||..|
llldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalklly

PDRITLIRGNHESRQITQVYGFYDECLKKYGSITVWRYCAEIFDYLSLSAIIDNRVFCVHGGLSPSISTLDQIRSIDRKQEVPHDGPMCDLLWSDPEDIQ
||...|.|||||.......|||.||.| |||.  .|... . ...| |.|.|......|||||||..|.|||||.|.| ...|..|...||||||| .. 
pdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlws

GWGVSPRGAGYLFGSDVVAQYNAANDIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLKREFTIFEAAP
||. |.||.|..|| ..| ..  .|..|||.|.||.|..||...|.. ..||.|||||..|.||..|.|.|||.|...|..|.. .
gwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapvl
subfamily_PPP1C_pd Subfamily PPP1C 19-288 6.7e-107 349.9 In-house 9-278 (282) alignment 
Range on Protein: 19-288
Range on HMM: 9-278/282.0
LITEKEVKQLCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESR
 ..|.|...|..||||||.... . ... ||...||||||..||  ||. .|  |..||||.||.||||  |.|| .||||.|..||... |.|||||| 
klkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesa

QITQVYGFYDECLKKYGsITVWRYCAEIFDYLSLSAIIDNRVFCVHGGLSPSISTLDQIRSIDRKQEVPHDGPMCDLLWSDPE-DIQGWGVSPRGAGYLF
.|...||||||| ..|. |..|.   ..|..| |.|..|....||||||||... |.|||.| |  |||..| .||||||||. ...||. . ||  . |
sinriyGfydeckrrys.iklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsftf

GSDVVAQYNAANDIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLKREFTIFEA
|.|||... . ||.|||.||||.| .||... .. ..||.|||||| . .| .|.|..||.|. .|.|. .
gkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkp
PP2Ac_SM00156 21-288 1.4e-105 345.2 In-house 2-269 (271) alignment 
Range on Protein: 21-288
Range on HMM: 2-269/271.0
TEKEVKQLCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQI
...||..|. ...||| .|.|. .|..||||.||||||..|| .|.. .| .|...|.|.||.|||| .|.|. |||.|||..||....| ||||||...
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TQVYGFYDECLKKYgSITVWRYCAEIFDYLSLSAIIDNRVFCVHGGLSPSISTLDQIRSIDRKQEVPHDGPMCDLLWSDP-EDIQGWGVSPRGAGYLFGS
...|||..|.  || .  ..  . |.|..|.|.|..|....|.||||||....||.||...| .| |..|...||||||| .. .|.  | ||....||.
nkiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFge

DVVAQYNAANDIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLKREFTIFEA
|.| ..  .|...||.|||..|.|||.. ... ..|..||||||....|.||.|.....|| ..  ...
davkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlke
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 10-289 3.8e-96 314.6 In-house 14-294 (298) alignment 
Range on Protein: 10-289
Range on HMM: 14-294/298.0
QIEKLRNCELITEKEVKQLCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRIT
 ... . .. |.|..|..|...|..|. . . .  ||.|..||||||||. ||  ||. .|  ||.||||.||.|||| ...|. .|||| ||.||... 
slsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnff

LIRGNHESRQITQVYGFYDECLKKYGSITVWRYCAEIFDYLSLSAIIDNRVFCVHGGLSPSISTLDQIRSIDRKQEVPHDGPMCDLLWSDPED-IQGWGV
|.|||||  .| .|||||.|| ..| |....    ..|. | | |.| .|..|.|||||. ...|||.|.. | .. ...    ||||.|||. ..||  
llrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkgwae

SPRGAGYLFGSDVVAQYNAANDIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLKREFTIFEAA
. ||... ||.|||..     ||||..||||.| .||..  .  ..|..|||.|| .  | ||....||.|.  |...  .
nsrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpe
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 18-294 1.1e-86 283.7 In-house 22-299 (299) alignment 
Range on Protein: 18-294
Range on HMM: 22-299/299.0
ELITEKEVKQLCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHES
. . |.|...||| |........ .  |..|. ||||||||. ||  .|.. |  ||.|.||.||.||||   .|.  |||. |..||.|. ..||||| 
ksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhec

RQITQVYGFYDECLKKYGSITVWRYCAEIFDYLSLSAIIDNRVFCVHGGLSPSISTLDQIRSIDRKQEVPHDGPMCDLLWSDPED-IQGWGVSPRGAGYL
  | .|||||.|| |.| |  .|    . |... |. .| .|..|.|||||| ..||||.| . | |. |      ||||.||.. ...|    ||  |.
painrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsyv

FGSDVVAQYNAANDIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLKREFTIFEAAPQDVR
|| ||||.     ||||..||||.| .||..  .  ..|..||| || .  | |||...|| |   |.... .|....
fgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpkslk
subfamily_PPP3C_pd Subfamily PPP3C 19-278 3.5e-85 279.5 In-house 40-312 (452) alignment 
Range on Protein: 19-278
Range on HMM: 40-312/452.0
LITEKEVKQLCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESR
 ..|... ..  .| ..| .|... .|..|.||.|||||||||| .||.||||  .|.|||.||.|||| .|.|. | |.|||. ||... |.|||||.|
rleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecr

QITQVYGFYDECLKKYgSITVWRYCAEIFDYLSLSAIIDNRVFCVHGGLSPSISTLDQIRSIDRKQEVPHDGPMCDLLWSDPEDI-QGW-------GVSP
 .|. . | .|| .|| | .|.  | | || | |.|..... .|||||||| |..||.|...|| .|.|. ||.|||||||| .  .           |.
hlteyftfkeeckiky.seevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpnsv

RGAGYLFGSDVVAQYNAANDIDLICRAHQLVMEGYKWHFN------ETVLTVWSAPNYCYRCGNVAAILELDEH
||  |...   |...  .||.  | |||.   .||. . .       ...|..|||||.    | ||.|.... 
rGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyenn
subfamily_PPP5C_pd Subfamily PPP5C 10-290 2.2e-84 276.2 In-house 24-310 (322) alignment 
Range on Protein: 10-290
Range on HMM: 24-310/322.0
QIEKLRNCELITEKEVKQLCAKAREILVEESNVQRVDSP----VTVCGDIHGQFYDLKELFKVGGDVPD-TNYLFMGDFVDRGFYSVETFLLLLALKVRY
 .|.... . . .| . .. ..|.|.| ... .  .. .    .||||||||||||| ..|.. | . .   ||| ||||||| .|||. |.||..|. |
llelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfklly

PDRITLIRGNHESRQITQVYGFYDECLKKYGSiTVWRYCAEIFDYLSLSAIIDNRVFCVHGGLSP-SISTLDQIRSIDRKQEVPHDGPMCDLLWSDPEDI
|... | |||||| .. ..||| .|. .|| . .|    .|.|..| |. .|...|. |||||      |||..| ||| .. |..| ...||||||.. 
PnhfflsrGnhesdnmnklyGfegevkakyte.kvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqea

QGWGVSPRGAGYLFGSDVVAQYNAANDIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILEL-DEHLKREFTIFEAAP
.| . | || |  || ||  ..   |...|| |.|.. .|||. . .  ..||.|||||| . || .|...| ...|| .|. ||| .
nGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktfeave
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 17-287 8.2e-84 274.4 In-house 4-281 (284) alignment 
Range on Protein: 17-287
Range on HMM: 4-281/284.0
C-ELITEKEVKQLCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDV------PDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRIT
| .|..|||. .|| .|||.. .|.  . ...||...||||||| ||. |... |         ...|||.||.|||| .|.|  .||.|.|...||...
cqkllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvf

LIRGNHESRQITQVYGFYDECLKKYgSITVWRYCAEIFDYLSLSAIIDNRVFCVHGGLSPSISTLDQIRSIDRKQEVPHDGPMCDLLWSDPE-DIQGWGV
|.||||||| . . |||| || |.| | ...      |  . |.|.......|.|||.|  .  |.|.  ..|  ..|  | ..|| |.||| ...|.  
llrgnhesrpvnmqygfyleckkry.sealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegyke

SPRGAGYLFGSDVVAQYNAANDIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLKREFTIFE
|||||| .||.. | ...   ..||. ||||.||.||..  .  ..|..||| || .  |.||.|..||.|   ||...
sprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlk
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 16-294 1.4e-83 273.3 In-house 4-280 (280) alignment 
Range on Protein: 16-294
Range on HMM: 4-280/280.0
NCelITEKEVKQLCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNH
.|  | | .....  | ..||. .. .  ||.||.||||.|||. ||  ||.  .  ||.||||.||.|||| . .|  ||||| |||||... ..||||
ac..ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnh

ESRQITQVYGFYDECLKKYgSITVWRYCAEIFDYLSLSAIIDNRVFCVHGGLSPSISTLDQIRSIDRKQEVPHDGPMCDLLWSDPE-DIQGWGVSPRGAG
|  .| . |||.||. ..| |  ..    |..| | | |..  |..|.|||||. . .||... . |  . ...    ||||.||| .. ||. ..||. 
evisinrkygfkdevkrry.slalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvs

YLFGSDVVAQYNAANDIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLKREFTIFEAAPQDVR
..||..|| ..    |||||.| ||.| .||..  .  ..||.|||.|.    | ||.| .||.|.  | ..  | ..|.
vifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpalrevk
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 18-286 3.3e-82 268.9 In-house 5-274 (281) alignment 
Range on Protein: 18-286
Range on HMM: 5-274/281.0
EL-ITEKEVKQLCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHE
.. .|..|....  ... |..||...  .|.|..| ||.|.|| |||.||.. | ||.. ..|.||.||||  |.|...||..||.||.||| |.|||||
kvqytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnhe

SRQITQVYGFYDECLKKYGsITVWRYCAEIFDYLSLSAIIDNRVFCVHGGLSPSISTLDQIRSIDRKQEVPHDGPMCDLLWSDPED-IQGWGVSPRGAGY
  .. ..|||| ||  ||| . .|    . |. | .|| |..|| |.|||||| . .||..| . .  . .. | . ||||.||..  ..|  | ||...
iasvnkiygfyvecvtkyG.eelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssf

LFGSDVVAQYNAANDIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLKREFTIF
.|| .|| .     ...|| ||||.|..||.      ..||.|.||||    | ||.| .|| |. ..  .
tfGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislval
PPP_2 49-240 2.1e-81 265.3 In-house 1-197 (198) alignment 
Range on Protein: 49-240
Range on HMM: 1-197/198.0
VTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLKKYGSITVWRYCAEIFD
||||||.|||..|| .|||.|...|...|||.||.|||| .|.|..|||||||..||....|.||||||.....||||..|.|||.|. .|.... |.|.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

YLSLSAIIDNRVFCVHGGLSPSISTLDQIRSIDRKQEVPHDGPMCDL-----LWSDPEDIQGWGVSPRGAGYLFGSDVVAQYNAANDIDLICRAHQL
.|.|.|.||..|..||||||..|..||||....||.|.|..|...||     |....|. ...  | ||||.|||.||...   .|...||.|||..
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 16-287 7.8e-78 254.7 In-house 19-293 (297) alignment 
Range on Protein: 16-287
Range on HMM: 19-293/297.0
NCELITEKEVKQLCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNH
 ...|||. | .|   | ...  . ..  |..|. ||||||||| ||  ||. ||  | .||||.||.|||| .|.|| .|||| ||..|  . |.||||
lskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnh

ESRQITQVYGFYDECLKKYGSITVWRYCAEIFDYLSLSAIIDNRVFCVHGGLSP---SISTLDQIRSIDRKQEVpHDGPMCDLLWSDPE-DIQGWGVSPR
|   . .|||||.|| |.| |. ..    ..|..| |. .| ....|.||||||      ||| .| |.| .|  ... ..||||.||   . |.    |
ecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfmenqr

GAGYLFGSDVVAQYNAANDIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLKREFTIFE
|||  || | | .  .  ..||.|||||.| .||..     ..|..||| || .  |.||..  ||.|.  | |. 
gagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilr
subfamily_PPZ_pd Subfamily PPZ 20-287 2.2e-76 250.2 In-house 25-292 (300) alignment 
Range on Protein: 20-287
Range on HMM: 25-292/300.0
ITEKEVKQLCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQ
. ..|. |.| ||||... . ..  .  .| . ||.|||. ||  ||   |  | .||||.||.||||  |.|| ||||. |..||. . |.|||||  .
lknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecan

ITQVYGFYDEClKKYGSITVWRYCAEIFDYLSLSAIIDNRVFCVHGGLSPSISTLDQIRSIDRKQEVPHDGPMCDLLWSDPEDI-QGWGVSPRGAGYLFG
.|.|||||||| |.   | .|.   . |. | |.||.  ..||||||||| . ..|.|| . |  .||  | . ||||||| |  . |    ||  | . 
vtrvygfydec.krrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycyn

SDVVAQYNAANDIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLKREFTIFE
   . ..     .||.|||| .| .||..  . ...||.||||||    |  |.. . | |   | ...
kvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelld
PPP_4 49-240 2.5e-76 249.1 In-house 1-196 (197) alignment 
Range on Protein: 49-240
Range on HMM: 1-196/197.0
VTVCGDIHGQFYDL-KELFKVGGDVP-DTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLKKyGSITVWRYCAEI
|||.||||||..||  .|.|.||. . ...|.|.||.|||| .|.|..|||||||..||....|.||||||......|||..|.|.|  . ...... ..
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FDYLSLSAIIDNRVFCVHGGLSPSISTLDQIRSIDRKQEVP-HDGPMCDL-LWSDPE-DIQGWGVSPRGAGYLFGSDVVAQYNAANDIDLICRAHQL
||.|.|.|.||..|..||||||.....||.|. |.||.|.| ... ..|| |||||. . .|.  | ||||.|||.||. .   .|...||.|.|.|
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 49-240 5e-75 244.9 In-house 1-198 (199) alignment 
Range on Protein: 49-240
Range on HMM: 1-198/199.0
VTVCGDIHGQFYDL-KELFKVGGDVP-DTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLKKYGSITVWRYCAEI
||||||.|||..||  .||| ||| . ...|.|.||.|||| .|.|..|||||||..||....|.|||||..|....|||..|.|.||..  ..... ..
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDYLSLSAIIDNRVFCVHGGLSPSISTLDQIRSIDRKQEVP-HDGPMCDL-LWSDPE-DIQG-WGVSPRGAGYLFGSDVVAQYNAANDIDLICRAHQL
||.|.|.|.||..|..|||||||.| ...... |.||.|.| ..| ..|| |||||. . .| .  | ||||.||| ||. .    |...||.|.|.|
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 17-284 1.5e-74 243.9 In-house 3-270 (280) alignment 
Range on Protein: 17-284
Range on HMM: 3-270/280.0
CELITEKEVKQLCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHE
|...| .|.  .      |..||||.   ..|. | |||| |. |.. || . | ||. . .|.||.||||   .| ..||..||.|| ||| |.|||||
cnvmtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhe

SRQITQVYGFYDECLKKYGsITVWRYCAEIFDYLSLSAIIDNRVFCVHGGLSPSISTLDQIRSIDRKQEVPHDGPMCDLLWSDPED-IQGWGVSPRGAGY
.  . ..|||| ||  ||| . .|     .|. . .|..| .||.|.|||||| .  || || | |  |    | . ||||||| .  .||  | ||  |
tpsvnkiygfyvecqykyg.vglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisy

LFGSDVVAQYNAANDIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLKREFT
.||  || |   . .|||| ||||.| .||.      ..||.| |||| .  | ||.. |.  |.  | 
mfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfq
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 13-287 1.5e-73 240.2 In-house 3-280 (287) alignment 
Range on Protein: 13-287
Range on HMM: 3-280/287.0
KLRNCELITEKEVKQLCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIR
|    . ...|.. ..  |..|||   . . .|..|.|..||||||. ||  .|.  |  |...|||.||.||||  |.|  |||..||..|| .. |.|
kygvldafsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllr

GNHESRQITQVYGFYDECLKKYGsITVWRYCAEIFDYLSLSAIIDNRVFCVHGGLSPSISTLDQIRSIDRKQE--VPHDGPMCDLLWSDPE-DIQGWGVS
|||| ..| ..|||..|  .|..   ...   ..|..|.| |....|..|.|||.|| . .||..... . .     ..| . ||||.||| | ..  . 
GnhevkkinklyGfkeelkrkrq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfeln

-PRGAGYLFGSDVVAQYNAANDIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLKREFTIFE
  |.   .||  .| ..    ||||| |||... |||.. |.. ..||.||| |. .  |..|.. ... |.  |. . 
kiraisvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlk
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 19-286 2.9e-70 229.9 In-house 2-271 (284) alignment 
Range on Protein: 19-286
Range on HMM: 2-271/284.0
LITEKEVKQLCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESR
||. ..|. |  .| .|. ..  .  |.||. .|||||||| ||  ||   |    .||||.||.|||| . .|| |||.| || .|... ..|||||  
lippedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecs

QITQVYGFYDECLKKYGSITVWRYCAEIFDYLSLSAIIDNRVFCVHGGLSPSISTLDQIRSIDRKQEVPHDGPM-CDLLWSDPEDIQ-GWGVSPRGAGYL
 | ..||||.|| ..|   .|.     .|  . |.|.. .|..|.|||.|  .  . |.|.| |  . |    .  |.||||| ..| ||    ||  |.
linkiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyv

FGSDVVAQYNAANDIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLKREFTIF
|||| . .     .|||. ||||.| .||..  |  ..|..||| || .  | ||.. ... |   | ..
fgsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvl
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 75-287 3.2e-70 229.8 In-house 101-313 (317) alignment 
Range on Protein: 75-287
Range on HMM: 101-313/317.0
TNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLKKYgSITVWRYCAEIFDYLSLSAIIDNRVFCVHGGLSPSISTL
 .|||.||.|||| .|.|  .||.|||..|||...|.||||||| . . |||| |. |.| | ...     .|  | |.|.......|.|||.| ..  |
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkry.saalyeafqlafnvlplcavvnkkilcmhGGiseelldl

DQIRSIDRKQEVPHDGPMCDLLWSDPE-DIQGWGVSPRGAGYLFGSDVVAQYNAANDIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAIL
.|.  ..|  ..|  | ..|| |.||. ...|.  |.|||| .||.. | ...   |.||. ||||.|..||..  .  ..|..|||.|| .  |.||.|
kqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavl

ELDEHLKREFTIFE
..|..||  .....
svdkklkisinvlr
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 11-286 7.4e-65 211.8 In-house 7-286 (290) alignment 
Range on Protein: 11-286
Range on HMM: 7-286/290.0
IEKLRNCELITEKEVKQLCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITL
..|    . ...|.. ..  |..|||     . .| .|... ||||||. .| . |.  |  |. ..||.||.||||  |.|  |||. .|.||. .. |
llkygvldafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhl

IRGNHESRQITQVYGFYDECLKKYGSiTVWRYCAEIFDYLSLSAIIDNRVFCVHGGLSPSISTLDQIRSIDRKQ--EVPHDGPMCDLLWSDPED--IQGW
.||||| |.. ..|||..|  .| ||  .|.   ..|. ||| | ......|.|||.|. | . . .... . .     ..| . ||||.||.    .  
lrgnhevrkvnrlygfkeelarkrgs.rlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddti

GV-SPRGAGYLFGSDVVAQYNAANDIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLKREFTIF
 .   |.   .|| ... ..     ..|| |||..  ||... |.. ..||.||| |. .  |. ||... | |. .....
alnkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvl
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 21-286 6.6e-62 202.4 In-house 21-289 (307) alignment 
Range on Protein: 21-286
Range on HMM: 21-289/307.0
TEKEVKQLCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQI
| .|....  .|. |.  |  .  .| |. | ||.|||| || ..| . |  |.| |.| ||.||||. |.|. |||.. |. ||. | |.|||||  ..
tkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarv

TQVYGFYDECLKKYGS--ITVWRYCAEIFDYLSLSAIIDNRVFCVHGGLSPSISTLDQIRSIDRKQEVPHDGPMCDLLWSDPE-DIQGWGVSPRGAGYLF
 . ||||.||.         .|      |. | .||.|  ...|.||||||... ||..|   .    |  | . |.||.||.  .  |  | ||.|. |
nkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftf

GSDVVAQYNAANDIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLKREFTIF
|..|. .      ..|| ||||....||       ..|..||| ||    |  ..| .|| |  .   |
gtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvaf
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 45-287 3.7e-56 183.7 In-house 5-254 (263) alignment 
Range on Protein: 45-287
Range on HMM: 5-254/263.0
VDSPVTVCGDIHGQFYDLKELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLKKYGSI----TVW
...|. .||| |||. ||  .|.  |    |.|||.||.|||| .|.|  .||..||.  | .. |.||||| . | . |||. |  |..       .|.
lqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvy

RYCAEIFDYLSLSAIIDNRVFCVHGGLSPSISTLDQIRSIDRKQEVPHDGPM-CDLLWSDPE-DIQGWGVS-PRGAGYLFGSDVVAQYNAANDIDLICRA
 .  ..| |. | ||. .|..|.|||.|| . .||.||.|    |  .  |. |||||.||| | .|.     |    .||   | .     ||||| ||
nhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidlivra

HQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLKREFTIFE
||.|  || .  .  ..||.||  |     | ||.. ... |.  |  ..
hqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlk
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 76-291 2.7e-54 177.5 In-house 121-336 (339) alignment 
Range on Protein: 76-291
Range on HMM: 121-336/339.0
NYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLKKYGSiTVWRYCAEIFDYLSLSAIIDNRVFCVHGGLSPSISTLD
 |||.||.|||| .|.|  .|| |||. ||||| |.||||||| .   |||| |   .| .  ..    ..|. . . |.|.| ..|.|||.|  .....
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyryda.qlyecfqnmfnvfpfcavinntimcmhggisehltsfn

QIRSIDRKQEVPHDGPMCDLLWSDPEDI-QGWGVSPRGAGYLFGSDVVAQYNAANDIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILE
|.  . |  |.|  | . || |.||.   .|.  | ||| ..||   .  .    |.... | ||.| .||..     ..|..|||||| .  | ||.. 
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs

LDEHLKREFTIFEAAPQ
.|..||    .|    .
idkklkisinvfrpesr
subfamily_PPPLV_pd Subfamily PPPLV 27-278 1.9e-53 174.6 In-house 4-278 (290) alignment 
Range on Protein: 27-278
Range on HMM: 4-278/290.0
QLCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDL----KELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQ
 || .| .||..| ..  ..||. | ||.||.. ||    | |...| |.  ...||.||.|||| .|||    |||||| || .. |.||||| . ...
slcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqe

VYGFYDECLKKYGSI--TVWRYCAEIFDYLSLSAIIDNRVFCVHGGLSPSISTLDQIRSID---RKQEVPHDG-PM-CDLLWSDPEDIQ-----------
 . .. |.  |.|     ||    ..||.| |.|.||..|||||.|.  .| |  .| .|.    . . . || |.  |.|||||.. .           
sieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvln

-GWG-VSPRGAGYLFGSDVVAQYNAANDIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCgNVAAILELDEH
 |.   . || |..|..| . ..   |... . |||.   .|..   .  .|||.|. .||    | ||.. .|..
eGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGss.neaalilvdkk
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 20-280 4.6e-53 173.3 In-house 6-291 (302) alignment 
Range on Protein: 20-280
Range on HMM: 6-291/302.0
ITEKEVKQLCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFKV-----------GGDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRI
 ...|. .|. .  | | .|... .. .|||. ||||||| ||  ...                    ..|.||.||||  |.|   |..|||| || . 
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

TLIRGNHESRQITQVYGFYDECLKKYGSIT---VWRYCAEIFDYLSLSAIIDNRVFCVHGGLSPSISTLDQIRSIDRK-QEVPHDGPMCDLLWSDPEDIQ
 |.|||||.. |   ||| .|  ...|      .|.   |.| .. |.|.. ....|||||.|| ...|..|..|.|  .|| .|    |||..|| |.|
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

GWGVSP----------RGAGYLFGSDVVAQYNAANDIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLK
.  . .          ||  ..|    | .     ...|| |||| . ||.|.. .. .||..|||.|     |  |.|..|   |
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngk
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 20-280 6.9e-53 172.8 In-house 7-292 (302) alignment 
Range on Protein: 20-280
Range on HMM: 7-292/302.0
ITEKEVKQLCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFKVG-----------GDVPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRI
 ...|. .|. .  | | .|... .. .|||. ||||||| ||  ...                    ..|.||.||||  |.|   |..|||| || . 
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

TLIRGNHESRQITQVYGFYDECLKKYGSIT---VWRYCAEIFDYLSLSAIIDNRVFCVHGGLSPSISTLDQIRSIDRK-QEVPHDGPMCDLLWSDPEDIQ
 |.|||||.. |   ||| .|  ...|      .|.   |.| .. |.|.. ....|||||.|| ...|..|..|.|  .|| .|    |||..|| |.|
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

GWGVSP----------RGAGYLFGSDVVAQYNAANDIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLK
.  . .          ||  ..|    | .     ...|| |||| . ||.|.. .. .||..|||.|     |  |.|..|   |
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngk
Metallophos Calcineurin-like phosphoesterase 48-240 2.3e-46 151.6 Pfam-A 2-198 (200) alignment 
Range on Protein: 48-240
Range on HMM: 2-198/200.0
PVTVCGDIHGQFYDL----KELFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLL--LALKVRYPDRITLIRGNHESRQITQVYGFYDECLK---------
...|.||.||...||     .|.|.... . ...||.||.|||| .| ||. ||  |.||...|... |.||||||......|||..|.||         
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------KYGSITVWRYCAEIFDYLSLSAIIDNRVFCVHGGLSPSISTLDQIrsidrkqevphdgpmcdllwsdpediqgwgv
                        ...   ..... |.|..|.| |..|......||.||.|  . |.|                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

sprgAGYLFGSDVVAQYNAANDIDLICRAHQL
    ...|||.|..      ...||..|.|. 
....gselfgpdalekllekygvdlvlrGHtH
subfamily_PPP7C_pd Subfamily PPP7C 4-184 1.5e-39 128.8 In-house 17-203 (383) alignment 
Range on Protein: 4-184
Range on HMM: 17-203/383.0
CSDLDRQIEKLRNCELITEKEVKQLCAKAREILVEESNVQRVDS----PVTVCGDIHGQFYDLKE-LFKVGGDVPDTNYLFMGDFVDRGFYSVETFLLLL
...... ||.... .|.  | | ..  .|...|..  |..|| .     ||||||.||.. ||   |.| |   .. .|.| |||||||  |||  |.||
kdeveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillill

ALKVRYPDRITLIRGNHESRQITQVYGFYDECLKKY--GSITVWRYCAEIFDYLSLSAIIDNRVFCVHGGLSPsISTLDQIRSIDRKQ
|| . ||  . | |||||   .   |||  |  .||   .  . |   ..| .| |...||.... ||||.|  .. |. . .|.|..
alllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisd.ktdlelldkiersk
subfamily_PPP7C_pd Subfamily PPP7C 192-289 6.1e-18 57.7 In-house 237-335 (383) alignment 
Range on Protein: 192-289
Range on HMM: 237-335/383.0
MCDLLWSDPEDIQG-WGVSPRGAGYLFGSDVVAQYNAANDIDLICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLKREFTIFEAA
. |.|||||.  .| .  . ||.|  ||.|| ..  .  ...|. |.|.  .|||..  ...|||..|| ||     |  | . | ..|. ..  . |.
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqas
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 17-70 1.8e-14 46.7 In-house 6-59 (317) alignment 
Range on Protein: 17-70
Range on HMM: 6-59/317.0
CELITEKEVKQLCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFKVGG
 .|..|||. .|| .|||.. .|    ....|||..||||||| ||. |... |
qdlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnG
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 17-69 5e-09 28.7 In-house 8-60 (339) alignment 
Range on Protein: 17-69
Range on HMM: 8-60/339.0
CELITEKEVKQLCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFKVG
 .|.   |. .|| .|||..  |  . ....|. | ||||||| ||  .. . 
ldlfcaaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmn
subfamily_YNL217W_pd Subfamily YNL217W 49-121 5.6e-06 19.0 In-house 12-80 (235) alignment 
Range on Protein: 49-121
Range on HMM: 12-80/235.0
VTVCGDIHGQFYDLKELFK--VGGDVPDTNYLFMGDFVDRGFYSVETFLLLlalkvrYPDRITLIRGNHESRQIT
. | ||.|| . .| ||..  .||  ..   ...||....|  |||.  ..        |    ..||||   . 
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvll