Gene PPP7C in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP7C
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP124_AA protein Get Run
NvecP124_AA_124-496 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP7C_pd Subfamily PPP7C 127-500 7.9e-201 659.7 In-house 2-383 (383) alignment 
Range on Protein: 127-500
Range on HMM: 2-383/383.0
VEPTYTGHVVKLPITLMSVRNIIEQCKLNKLVHAKYVLLILREARERFRALPNVIRVTTRIAKQMTICGDLHGKLDDLFMIFHKNGLPSPENPYIFNGDL
|| .|||. ..||.|...|...||..|..||.||||||||||||......|||. ||.|.|.|..|.|||||||||||..|..||||||.||||.||||.
vedsytgprlslpltkdeveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdf

VDRGPRSIEICIILFAFTILYPNGVYINRGNHEDHIMNLRYGFVKEVMDKYKDHASKIIRLFEDIFGWLPLATIVNNKIFVAHGGISNITDLDIIERIDR
|||| .|.||..||.|....||. ||.|||||||||.||||||.|||..|||.|..||.||.||.| ||||||....||...|||||..|||.....|.|
vdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdktdlelldkier

HKYVSVLKPP-------NIVKDNPSLSS-LKEWRQVLDLLWSDPKPTPGCKPNTFRGGGCYFGPDVTSQVLRKHNFELLVRSHECKYEGYEYMHNKKVIT
.|.||||.||       .  |.. |..   .|||||||.|||||| . ||||||.||||.|||||||...|.|.|..||.||||||.||||..|.|||.|
sklvsvlrpplkegeeaekekeessvkvdkeewrqvldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvlt

IFSASNYYEQGSNRGAYMKIGPDMTPYFVQYQVSRTKKHLTLKQRVGIVEESAIRELKEKLYANKSALMEAFTKRDEQHTGY
|||||||||.|||||||.|.|.|.||..||||.|...|.|||.|||.||||||.|||.|||.|.||.|.|.|.|.||...|.
ifsasnyyeeGsnrGayvklgkdltprivqyqaskatkkltlrqrvsiveesalrelrekllakksdlleefkkkdekksgl
0045823 Metallo-dependent phosphatases 125-496 6.1e-97 318.2 In-house 10-365 (473) alignment 
Range on Protein: 125-496
Range on HMM: 10-365/473.0
IKVEPTYTGHVVKLPITLMSVRNIIEQCKLNKLVHAKYVLLILREARERFRALPNVIRVTTRiakqMTICGDLHGKLDDLFMIFHKNGLPSPeNPYIFNG
|.|   .|..... ...|. .. .||. | ..|......| .|.||.| ..  ||..... |     ...||.|| ||||  ...|.|.|.. . ..|.|
ipvlrlltlpllfillglldldlliehlkkegllpeedllklldeakeilkkepnllelsmr....ivviGDiHGqlddLlrllekigfppe.drlvflG

DLVDRGPRSIEICIILFAFTILYPNGVYINRGNHEDHIMNLRYGFVKEVMDKYKDHaskIIRLFEDIFGWLPLATIVNNKIFVAHGGISNI-TDLDIIER
||||||| |.|.  .|.|. |.||. |.. |||||....|  ||| .|...|| ..   . . | . . .|||| ....||...|||.|   . || |..
DlvDrGpdslevlelllalkikypgnvfllrGNHElrllnglygfgdetlekyged...lyeeflewlrslPlaaviggkilfvHGGlspdlplldqire

IDRHKYVSVlkppnivkdnpslsslkeWRQVLDLLWSDPKPTPGC-------KPNTFRGGGCYFGPDVTSQVLRKHNFELLVRSHECKYEGYEYMHNKK-
|.|  ...                   ....|||||||| .. |.        .|..|| |..||||.. ..|.|... |.||.|..  ||||.....| 
ierpleipd..................dgllldllwsdPweddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkv

-----VITIFSASNYYEQGSNRGAYMKIGPDMtPYFVQYQVSRTKKHLTLKQRVGIVeesAIRELKEKLYANKSALMEAFTKRDEQ
     .||.|||.||. .| |..|...|..|. ..|.|.. | ... |.| ..|...   ... | |||.   . |. ......  
igiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsphplilplfldvfll...slpfllekltellllllnivsddell
PPP_3 167-450 5.2e-94 307.2 In-house 7-270 (271) alignment 
Range on Protein: 167-450
Range on HMM: 7-270/271.0
LREARERFRALPNVIRVTTRIAKQMTICGDLHGKLDDLfMIFHKNGLPSPENPYIFNGDLVDRGPRSIEICIILFAFTILYPNGVYINRGNHEDHIMNLR
|.|  .. . ...  .....| ...|.|||.||.|||| ....|||.||||. |.|.|| ||||  |.|. ..|.|. |.||. |...|||||.. .| .
lkelvkklkeilekesnlveisapvtvcGDiHGqldDL.lelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqinkv

YGFVKEVMdkYKDHASKIIRLFEDIFGWLPLATIVNNKIFVAHGGISNITDL-DIIERIDRHkYVSVLKPPNIVKDnpslsslkewrqvldllWSDPKPT
||| |||.  .| . .|. . ....| .||||.....|..|.|||.|. ... | |....|.  ... . . . .                  .|... .
YgFkkevl..kkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerk.ievpeegklldll.................lssdpek

PGCKPNTFRGGGCYFGPDVTSQVLRKHNFELLVRSHECKYEGYEYMHNKKVITIFSASNYYEQGSNRGAYMKIGPDMTPYFVQYQ
 ... |. || |..||||||...|.|....|..|.||.| ||||..|..||.|.|||.||.|..||.||..|.....|. |.|..
eeglenskrGagllFgpdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
PPP_1 168-437 5.7e-94 307.3 In-house 7-263 (264) alignment 
Range on Protein: 168-437
Range on HMM: 7-263/264.0
REARERFRALPNVIRVTTRIAKQMTICGDLHGKLDDLfMIFHKNGLPSPENPYIFNGDLVDRGPRSIEICIILFAFTILYPNGVYINRGNHEDHIMNLRY
.|  .. . |.|  ...... ...|.|||.||..||| ... |.|.||||. |.|.|| ||||  |.|| ..|.|. . ||. ....|||||.. .. .|
aelkkklkellnkeenllevseeitvcGDiHGqfdDL.lklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvtkvy

GFVKEVMdkYKDHASKIIRLFEDIFGWLPLATIVNNKIFVAHGGISNITDLDIIERIDRHKYVSVLKPPNIVKD--NpslsslkewrqvLDLLWSDPKPT
|| |||.  .| . ..| ....|.| .||||.....||.. |||.|...||    |. |.| ... . .   .   .             | |.||.| .
gFkkEvl..kkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekd............vdillsddkeq

PGCKPNTFRGGGCYFGPDVTSQVLRKHNFELLVRSHECKYEGYEYMHNKKVITIFSASNYYEQGSNRGAYMK
 ....|. ||.|..||.|||...|.|.|..|..|.||.| ||||.....||.||||||||||.|||||||.|
eeavansiRGagylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
subfamily_PPP5C_pd Subfamily PPP5C 127-451 3.7e-91 298.5 In-house 2-308 (322) alignment 
Range on Protein: 127-451
Range on HMM: 2-308/322.0
VEPTYTGHVVKL-PITLMSVRNIIEQCKLNKLVHAKYVLLILREARERFRALPNVIRVTTRIAKQMTICGDLHGKLDDLFMIFHKNGLPSPENPYIFNGD
||  |.|  ..   ||   |....|. | .| .| ||.| || ||.| ...|| .. .|.   |..|.|||.||.  ||. ||..|||||.||||.||||
vedsydgpkleeekitkefvkellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGd

LVDRGPRSIEICIILFAFTILYPNGVYINRGNHEDHIMNLRYGFVKEVMDKYKdhaSKIIRLFEDIFGWLPLATIVNNKIFVAHGGISNIT--DLDIIER
.||||  |.|. ..|..| .|||| ....||||| . ||  |||  ||  ||.   .|.. || ..| |||||...|.|..| |||. .     || . .
fvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyGfegevkakyt...ekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrk

IDRHKyvsvlKPPNivkDNpslsslkewrQVLDLLWSDPKPTPGCKPNTfRGGGCYFGPDVTSQVLRKHNFELLVRSHECKYEGYEYMHNKKVITIFSAS
|||..     .||.   ..          ....||||||....| .| . || |..||||||.. |.. |.||..|||| | |||| .|. |.||.||| 
idrna.....qppe...eg..........llvellwsdpqeanGrspsk.rGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsap

NYYEQGSNRGAYMKI-GPDMTPYFVQYQV
|| .| .|.||.... | |... | ... 
nycdqmgnkgafitlrgddlklkfktfea
PP2Ac_SM00156 159-450 4.2e-91 297.7 In-house 2-268 (271) alignment 
Range on Protein: 159-450
Range on HMM: 2-268/271.0
HAKYVLLILREARERFRALPNVIRVTtriaKQMTICGDLHGKLDDLFMIFHKNGlPSPENPYIFNGDLVDRGPRSIEICIILFAFTILYPNGVYINRGNH
....|| .|.|..| ... .|...|.    .. |..||.||.||||. .....| ..||..|.|.|| |||||.|||. ..|||. ||||. |...||||
skeevlelleevkeilkqeknlvevs....apvtvvGdihGqlddllrllelag.eppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnH

EDHIMNLRYGFVKEVMDKYkdhASKIIRLFEDIFGWLPLATIVNNKIFVAHGGISN-ITDLDIIERIDRhkyvsvlkppnivkdnpsLSSLKEWRQVLDL
|.  .|  ||| .||. ||   ...|   ||..| .||||..|..||.. |||.|. .. || |....|                       |. ...||
Esssvnkiygfeeevkrky...gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkr..................vkekpeegllidl

LWSDP-KPTPGCKPNTfRGGGCYFGPDVTSQVLRKHNFELLVRSHECKYEGYEYMHNKKVITIFSASNYYEQGSNRGAYMKIGPDMTPYFVQYQ
||||| ....|..|.. || ...||.|.....|.|.|..|..|.||.. ||||....||..|||||.||... || .|..|.  .......|..
lwsdpeqkekgfqpsk.rglsvvFgedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlk
0049330 Metallo-dependent phosphatases 132-454 9.5e-81 264.3 In-house 4-301 (309) alignment 
Range on Protein: 132-454
Range on HMM: 4-301/309.0
TGHVVKLPITLMSVRNIIEQCKLNKLVHAKYVLLILREARERFRALPNVIRVTTRiakqMTICGDLHGKLDDLFMIFHKNGLPSPeNPYIFNGDLVDRGP
..... |...|  .  .||. .  ||.. ...||.| .|.| ..  ||..... |     ...||.|| ||||  ...|.|.|.. . ..|.||||||||
ldpllllelilslldllielllklkllseeellllllkakeilksepnllelsmr....ivviGDiHGqlddLlrllekigfppe.drlvflGDlvdrGp

RSIEICIILFAFTILYPNGVYINRGNHEDHIMNLRYGFVKEVMDKYKdhaSKIIRLFEDIFGWLPLATIVNNKIFVAHGGISNIT-DLDIIERIDRHKYV
 |.|.  .|.|. .|||..|.. |||||....|  ||| .|.. ||    ... . | | . .|||| ....||...|||.|.    || |....|. ..
dslevlllllalkllypdnvfllrGNHElrllnglygfgdetlrkyg...aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerplei

SVLKppnivkdnpslsslkewrQVLDLLWSDPKPTPGCKPNTFRGGGCYFGPDVTSQVLRKHNFELLVRSHECKYEGYEYMHNKKVITIFSASNYYEQGS
                       . ||||||| |.    ..  || |..||.... ..|.|....|..|.|.. ..||......|.||.|||.||... .
pldg..................llcdllwsdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlg

NRGAYMKIGPDMTPYFVQYQVSRT
|.||...|..|....|...... .
nlgavleidedlvisfllfepvpl
0053225 Metallo-dependent phosphatases 141-451 1.7e-77 253.7 In-house 5-290 (293) alignment 
Range on Protein: 141-451
Range on HMM: 5-290/293.0
TLMSVRNIIEQCKLNKLVHAKYVLLILREARERFRALPNVIRVTTRiakqMTICGDLHGKLDDLFMIFHKNGLPSPeNPYIFNGDLVDRGPRSIEICIIL
.|. .  .||. .|.||......||.| ||.| ..  ||..... |     ...||.|| ||||  ...| |.|.. . ..|.|||||||| |.|.. .|
illlldllielllllkllseeelllllleakeilkkepnllelsmr....iyviGDiHGnlddLlallekigfppe.drlvflGDlvdrGpdslevlell

FAFTILYPNGVYINRGNHEDHIMNLRYGFVKEVMDKYKdhASKIIRLFEDIFGWLPLATIVNNKIFVAHGGIS-NITDLDIIERIDRHKYVSvlkppniv
.|. .|||..|.. |||||....|  ||| .|...||   |... . . | . .|||| ....||...|||.| ... || |..|.|. ..         
lalkllypdnvvllrGNHElmllnglygfgdetlrkyg..aaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplrip........

kdnpslsslkEWRQVLDLLWSDPKPTPGCKPNtFRGGGCYFGPDVTSQVLRKHNFELLVRSHECKYEGYEYMHNKKVITIFSASNYYEQGSNRGAYMKIG
          ... .||||||||    |. |. .|| |..||.... ..|.|....|..|.|.. ..||......|..|.|||.||... .|.||.....
..........legllldllwsdpdlwsgwlps.yrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlald

PDMTPYFVQYQV
..... |... .
eglvwgfklfap
PPP_5_Dcr2 192-404 5.6e-71 231.6 In-house 2-199 (199) alignment 
Range on Protein: 192-404
Range on HMM: 2-199/199.0
TICGDLHGKLDDLFMIFHKNG-LPSPENPYIFNGDLVDRGPRSIEICIILFAFTILYPNGVYINRGNHEDHIMNLRYGFVKEVMDKYkdHASKIIRLFED
|.||||||.||||..|. |.| .||.|. |.|.|| ||||..|.|. ..|.|. ..||. |...||||||. .|..||| |||..||  | .|| . ..|
tvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlsky..hgkkiykilsd

IFGWLPLATIVNNKIFVAHGGISNITDL-DIIERIDRhKYVSvlkppnivkdnP----S----LsslkewrqvldlLWSDPK-PTPGCKPNTFRGGGCYF
.| |||||.....|..|.|||.|..... . .|.|.| |...           |         |            |||||.  . ||| |. ||.|..|
vfdwlPlaalidekvlvvhgglspeiksiellekier.kiei...........peekgekadll............lwsdprdaqegcklnseRGagllf

GPDVTSQVLRKHNFELLVRSHECK
|||||...|.|.|..|..||||.|
gpdvtekfleknnlkliirshelk
PPP_4 192-404 1.5e-69 227.0 In-house 2-197 (197) alignment 
Range on Protein: 192-404
Range on HMM: 2-197/197.0
TICGDLHGKLDDLFMIFHKNG-LPSPENPYIFNGDLVDRGPRSIEICIILFAFTILYPNGVYINRGNHEDHIMNLRYGFVKEVMDKykdHASKIIRLFED
|..||.||.||||.... ||| |||.|. |.|.|| ||||..|.|. ..|.|. . ||. |...|||||.. .||.||| |||..|   | ..| . ..|
tvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek...hgkeilkklqd

IFGWLPLATIVNNKIFVAHGGISNITD-LDIIERIDRHkYVSvlkppnivkdnpslsS---------LkewrqvldlLWSDPK-PTPGcKPNTFRGGGCY
.| .||||.....|..|.|||.|.... || ||||.|  ..|               .         |         |||||.  . | . |. ||.|..
vfdllplaalidekvlvvhgglsdelesldkierierk.ies...............pleeekrkdll.........lwsdpreaqeg.lansvrGagll

FGPDVTSQVLRKHNFELLVRSHECK
||||||...|.|.|..|..||||.|
Fgpdvtekfleknnlkliirshelk
PPP_2 192-404 3.2e-69 225.6 In-house 2-198 (198) alignment 
Range on Protein: 192-404
Range on HMM: 2-198/198.0
TICGDLHGKLDDLfMIFHKNGLPSPENPYIFNGDLVDRGPRSIEICIILFAFTILYPNGVYINRGNHEDHIMNLRYGFVKEVMdkYKDHASKIIRLFEDI
|.||||||.|||| .|..||||||||. |.|.|| |||| .|.|. ..|.|. . ||. |...|||||.. .| .||| |||.  .| . .|. . ....
tvcGDlHGqldDL.lilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevl..kkkggkkvykklqev

FGWLPLATIVNNKIFVAHGGISNITDLDIIERIDRHKYVSVLKPPNIVKD---NpslsslkewrqvldllWSDPKPTPGCKPNTFRGGGCYFGPDVTSQV
| .||||.....|..|.|||.|. ..|    . ...| .|. . . . .    .                .|||| . ... |. ||.|..||||||...
felLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeek................lsdpkekeellansarGagllfgpdvteel

LRKHNFELLVRSHECK
|.|....|..|.||.|
leknklkliiRaHevk
subfamily_PPP1C_pd Subfamily PPP1C 157-447 7.8e-68 221.7 In-house 9-274 (282) alignment 
Range on Protein: 157-447
Range on HMM: 9-274/282.0
LVHAKYVLLILREARERFRALPNVIRVTTriakQMTICGDLHGKLDDLFMIFHKNGLPsPENPYIFNGDLVDRGPRSIEICIILFAFTILYPNGVYINRG
 .. . .  .|..||| . . | .....      ..|.||.||.. ||  .|...| | ||. |.| || |||| .|.|. ..|.|. | ||. ... ||
klkeaeieallkkareillsqpillelea....PvkivgdihGqyadllrlfetsgaP.pesnylflGdyvdrGkqsletivlllaykikypenlfllrG

NHEDHIMNLRYGFVKEVMDKYKDHaskIIRLFEDIFGWLPLATIVNNKIFVAHGGIS-NITDLDIIERIDRHKYVSVLkppnivkdnpslsslkewRQVL
|||.  .|  |||  |.  .|. .   . . | |.|..||||..|..||...|||.| ....|. |..| |   |.                      . 
nhesasinriyGfydeckrrysik...lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpek..................gllc

DLLWSDPKPTP-GCKPNTfRGGGCYFGPDVTSQVLRKHNFELLVRSHECKYEGYEYMHNKKVITIFSASNYYEQGSNRGAYMKIGPDMTPYFV
|||||||. .  | . |. ||    ||.|| ...|.|....|.||.|..  .|||.. .....|.|||.|| ..  | || ...  ...  | 
dllWsdpdkevlgwsend.rGvsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfq
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 147-450 2.7e-62 203.5 In-house 13-292 (298) alignment 
Range on Protein: 147-450
Range on HMM: 13-292/298.0
NIIEQCKLNKLVHAKYVLLILREARERFRALPNVIRVTTRIakqmTICGDLHGKLDDLFMIFHKNGLPSPENpYIFNGDLVDRGPRSIEICIILFAFTIL
  ....|| | .. . |  ....|.. |.. . .. | . |    ..|||.||.  ||. .|.|.| |  .| |.| || ||||  ..|. ..|.|. . 
vslsekkltkvikeedveklielakkifkkqkslvevdapi....kvcGdihGqysdllrlfdkagfppdan.ylflGdyvdrGrqnlevivlllaykvk

YPNGVYINRGNHEDHIMNLRYGFVKEVMDKYKDHAskIIRLFEDIFGWLPLATIVNNKIFVAHGGISN-ITDLDIIERIDRhkyvsvlkpPNiVKDNPSL
||| ... ||||| ...|  ||| .|.  .||. .  .   |.|.| .|||.... ..|.  |||.|. .. || . .. |         |   ....||
ypnnffllrGnheceainrvyGfyeeckrrykslr..lyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkr.........pf.dskeesl

sslkewrqVLDLLWSDPKP-TPGCKPNTfRGGGCYFGPDVTSQVLRKHNFELLVRSHECKYEGYEYMHNKKVITIFSASNYYEQGSNRGAYMKIGPDMTP
        . ||||.||.  . | ..|. || .. || ||  ..| | . .|.||.|    .|||.. .||..||||| .| .|  |  | ||.  ... 
........aidllwadpenavkgwaens.rGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvv

YFVQYQ
 |. ..
sfevlk
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 160-448 4.6e-58 189.4 In-house 12-278 (287) alignment 
Range on Protein: 160-448
Range on HMM: 12-278/287.0
AKYVLLILREARERFRALPNVIRVTTRIakqmTICGDLHGKLDDLFMIFHKNGLPsPENPYIFNGDLVDRGPRSIEICIILFAFTILYPNGVYINRGNHE
 | .| .|....| .. || ...|.. |    ||.||.||.||||. ||.. | . |.  |.| || ||||..|.|. ..||.. |.||. |.. |||||
dkdilevlekieeileplpalleveapi....tivGdihGqlddllrifnavGaa.pkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhe

DHIMNLRYGFVKEVMDKYKdhaSKIIRLFEDIFGWLPLATIVNNKIFVAHGGISN-ITDLDIIERIDRHkyvsvlkppnivkdNPSLSSlkEWRQVLDLL
 . .|  ||| .|.. |..   ... . |.|.|  ||| ..|...|.  |||||. .  || .. . .               .  |.   .   ..|||
vkkinklyGfkeelkrkrq...erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkp..............ttplac..deglqvdll

WSDPK-PTPGCKPNTFRGGGCYFGPDVTSQVLRKHNFELLVRSHECKYEGYEYMHNKKVITIFSASNYYEQGSNRGAYMKIGPDMTPYFVQ
|.||.  . . ..|  |.    ||  .  ..|.| . .|.||.|| . |||... .|...|.|||. |  . .| || ...   .   ||.
wadpekdaktfelnkiraisvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvv
subfamily_PPP4C_pd Subfamily PPP4C 147-447 3.5e-55 180.3 In-house 5-280 (288) alignment 
Range on Protein: 147-447
Range on HMM: 5-280/288.0
NIIEQCKLNKLVHAKYVLLILREARERFRALPNVIRVTTriakQMTICGDLHGKLDDLFMIFHKNGlPSPENPYIFNGDLVDRGPRSIEICIILFAFTIL
. ||. .  .|.. . |  . ..||| .    || || .     .|.|||.||.. ||  .|. .|   ||. |.| ||.||||  |.|  ..| |. . 
rqieklrrcelikeeevkalcakareilveesnvqrvds....pvtvcgdihgqfydllelfkvgg.dvpetnylflgdfvdrgfysvetfllllalkvr

YPNGVYINRGNHEDHIMNLRYGFVKEVMDKYKDhaSKIIRLFEDIFGWLPLATIVNNKIFVAHGGIS-NITDLDIIERIDRHKYVsvlkpPnivKDNPsl
||. ... |||||   .   ||| .|.. || .  ... |.  ..| .|.||.|...|||. |||.| .|. || |  |||.. |     |   .. |  
ypdritlirgnhesrqitqvygfydeclrkygs..anvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqev.....p...hegp..

sslkewrqVLDLLWSDPKPTPGCKpNTFRGGGCYFGPDVTSQVLRKHNFELLVRSHECKYEGYEYMHNKKVITIFSASNYYEQGSNRGAYMKIGPDMTPY
        . |||||||. . |    . || |  || ||..|  .. ..||..|.|.   ||| .. |.||.|..|| ||  .  |  | ...  ..   
........lcdllwsdpedaegwa.vsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkd

FV
| 
fk
subfamily_PPP2C_pd Subfamily PPP2C 146-453 1.5e-54 178.2 In-house 5-287 (290) alignment 
Range on Protein: 146-453
Range on HMM: 5-287/290.0
RNIIEQCKLNKLVHAKYVLLILREARERFRALPNVIRVTTriakQMTICGDLHGKLDDLFMIFHKnGLPSPENPYIFNGDLVDRGPRSIEICIILFAFTI
 ..||. |  | .. . |  .  .|.| ..   ||  | .     .|.|||.||.. ||. .|.  |  ||.  |.| || ||||  |.|   .| |. .
dklieklkeckqleesevkelcekakeilskesnvqevkc....pvtvcgdvhgqfhdllelfki.ggkspdtnylflgdyvdrgyysvetvtllvalkv

LYPNGVYINRGNHEDHIMNLRYGFVKEVMDKYKDhaSKIIRLFEDIFGWLPLATIVNNKIFVAHGGIS-NITDLDIIERIDRHKYVsvlkpPnivKDNPs
 |.. . | |||||   .   |||  |.. || .  ... ..| |.| .|||...|...||. |||.| .|. || |. .|| . |     |   .. | 
rykeritilrgnhesrqitqvygfydeclrkygn..anvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqev.....p...hegp.

lsslkewrqVLDLLWSDPKPTPGCKpNTFRGGGCYFGPDVTSQVLRKHNFELLVRSHECKYEGYEYMHNKKVITIFSASNYYEQGSNRGAYMKIGPDMTP
         . |||||||    |    . || |  || |.. .  .. ...|..|.|.   |||...|...|.||||| ||  .  |..| ...  ... 
.........lcdllwsdpddrggwg.isprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklky

YFVQYQVSR
.|.|.. . 
sflqfdpap
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 155-446 2.1e-54 177.9 In-house 5-277 (284) alignment 
Range on Protein: 155-446
Range on HMM: 5-277/284.0
NKLVHAKYVLLILREARERFRALPnvirVTTRIAKQMTICGDLHGKLDDLFMIFHKNGLP-----SPENPYIFNGDLVDRGPRSIEICIILFAFTILYPN
.||.. | .. .   ||| |   .    .   |   ..|.||.||. .|| .... || |     . |. |.| || ||||| |||.  .|||. .|.|.
qkllkekelielcyrarelfwkek....lkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpd

GVYINRGNHEDHIMNLRYGFVKEVMDKYkdhASKIIRLFEDIFGWLPLATIVNNKIFVAHGGISN-ITDLDIIERIDRhkyvsvlkpPNivkDNPSLSSl
 |.. |||||   .| .||| .|   .|   . ..   |.  |  .||...|..||.  |||||. . ||. .....|         |    | | .   
kvfllrgnhesrpvnmqygfyleckkry...sealyeafqlafnamplcavvskkiicmhggisedlldlkqldkler.........pi...dipdigv.

kewrqVLDLLWSDPKPTPGCKPNTFRGGGCYFGPDVTSQVLRKHNFELLVRSHECKYEGYEYMHNKKVITIFSASNYYEQGSNRGAYMKIGPDMTPYF
     . || |.||. .     .. || |  ||..   . |.|....|.||.|.   .|||.. ..|..|||||  |  |  | .| ...  ..   |
.....iadltwadpeaevegykesprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasf
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 160-440 2.3e-53 174.1 In-house 18-277 (290) alignment 
Range on Protein: 160-440
Range on HMM: 18-277/290.0
AKYVLLILREARERFRALPNVIRVTtriaKQMTICGDLHGKLDDLFMIFHKNGLPsPENPYIFNGDLVDRGPRSIEICIILFAFTILYPNGVYINRGNHE
 | .| ||....| .. || ...|     . ..| ||.||.||.|.  |.. | | |.  ..| || ||||..|.|....|| . |.|.. |.. |||||
dkdileilekieeileplpalleve....apivivgdihgqldallryfdavgyp.pkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhe

DHIMNLRYGFVKEVMDKykdHASKIIRLFEDIFGWLPLATIVNNKIFVAHGGISNitdldiieRIDRHKYVSVLKPPNIVKDNpslsslKEwRQVLDLLW
   .|  ||| .|.. |    .|.. . ..|.|  |.| . |..||.  |||||.        .|.  . .  || |..  .       .|   ..||||
vrkvnrlygfkeelark...rgsrlwkqyqdvfaelslcarvgrkilcmhggisq........kiesweslkalkkprvpltc......de.glqvdllw

SDPKP--TPGCKPNTFRGGGCYFGPDVTSQVLRKHNFELLVRSHECKYEGYEYMHNKKVITIFSASNYYEQGSNRGAYMKIGP
.||.   .   . |  |.    || ..  ..|.|  ..|.||.|| | ||.... .||..|.|||  |  . .| || ...  
adptrdkddtialnkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvse
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 152-454 4.9e-52 170.0 In-house 18-296 (299) alignment 
Range on Protein: 152-454
Range on HMM: 18-296/299.0
CKLNKLVHAKYVLLILREARERFRALPNVIRVTTRIakqmTICGDLHGKLDDLFMIFHKNGLPsPENPYIFNGDLVDRGPRSIEICIILFAFTILYPNGV
 .| | |. . .  . . |.. |   . .. | . |     .|||.||.  ||. ||.|.|.| |.  ..| || |||| . .|. ..|..| | ||.  
krltksvkeqelqtlcavaksvfasqaslleveapi....ivcgdihgqysdllrifdkagfp.pdvnflflgdyvdrgrqnlelitlllcfkikyperf

YINRGNHEDHIMNLRYGFVKEVMDKYKdhASKIIRLFEDIFGWLPLATIVNNKIFVAHGGIS-NITDLDIIERIDRHKyvsvlKPPnivkdNPSLSslke
.. |||||   .|  ||| .|.  .||  ....  .|.| | ..||. .....|.. |||.| ....|| .  . | .      ||     ||||.    
fmlrgnhecpainrvygfyeecnkryk..strlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpq.....dpp.....npslg....

wrqvLDLLWSDPKPT-PGCKPNTfRGGGCYFGPDVTSQVLRKHNFELLVRSHECKYEGYEYMHNKKVITIFSASNYYEQGSNRGAYMKIGPDMTPYFVQY
    .||||.||  .  . ..|. ||    ||.|| ..|. . . .|. |.|.   .|||.. .||..|||||  |  |  |  | ||.  ..   || .
....idllwadpdqsvkdwlanv.rgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvl

QVSRT
. .  
kptpk
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 152-438 3.6e-50 163.9 In-house 17-281 (297) alignment 
Range on Protein: 152-438
Range on HMM: 17-281/297.0
CKLNKLVHAKYVLLILREARERFRALPNVIRVTTRIakqmTICGDLHGKLDDLFMIFHKNGLPsPENPYIFNGDLVDRGPRSIEICIILFAFTILYPNGV
  | |..  . || .|  | . |.|  ... | . |     .|||.||.. ||. .||. | | |   |.| || ||||  |||  ..|.|. . .|  .
kllskviteervlklldlaldvfkaqksmvevnapi....kvcgdihgqfpdllrlfhrggwp.ptanylflgdyvdrgrfsietivlllaykvkfpgnl

YINRGNHEDHIMNLRYGFVKEVMDKYKdhASKIIRLFEDIFGWLPLATIVNNKIFVAHGGISNITDLDIIerIDRHKyvsvlkppNIVKdnpSlSSLKEw
.. |||||  ..|  ||| .|.  .|.  . ..   |.|.| ||||. .. .||.. |||.| .   ..   .|  .        .| .   | .  || 
fllrgnhecefvnkvygfyeecqkryq..svrmyaafqdvfnwlpltgliatkilcmhgglsplltkeft..ldtlr........kier...s.tegke.

RQVLDLLWSDPKPTPGCKPNTFRGGGCYFGPDVTSQVLRKHNFELLVRSHECKYEGYEYMHNKKVITIFSASNYYEQGSNRGAYMKI
| | ||||.||        .  || || || |   ..  . ...|..|.|.   .|||..  .|..|||||  |  |  |  |.|  
rlvadllwadpisglsgfmenqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmsc
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 185-439 6.2e-49 159.6 In-house 29-262 (280) alignment 
Range on Protein: 185-439
Range on HMM: 29-262/280.0
TRIAKQMTICGDLHGKLDDLFMIFHKNGLPsPENPYIFNGDLVDRGPRSIEICIILFAFTILYPNGVYINRGNHEDHIMNLRYGFVKEVMDKYKDhasKI
  .   ...||||||.  ||. .| . ..| |.. |.| || ||||   .|. ..|.|. . |||. .| |||||   .| .|||  ||. .|..   ..
vevdapvavcgdlhgqytdllrlfarvsfp.pdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinrkygfkdevkrrysl...al

IRLFEDIFGWLPLATIVNNKIFVAHGGISN-ITDLDIIERIDRhkyvsVLKPPNivkdnPSLSSlkewrqvlDLLWSDPKPTPGCKPNTFRGGGCYFGPD
   |....  |||...|. .|.. |||.|. .  || . .. |      .....      .|.         ||||.||.       .. ||    || .
ynefqelldslplvalvsgrilcmhgglsqklvslddlaelrr.....pfdsed.....eclam........dllwadpenkvtgwaensrgvsvifgan

VTSQVLRKHNFELLVRSHECKYEGYEYMHNKKVITIFSASNYYEQGSNRGAYMKIG
|  .. .| . .|..| |.   .|||.. .||..|.||| .| .. .|  | ... 
vvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivd
subfamily_PPP3C_pd Subfamily PPP3C 157-442 1.4e-48 158.8 In-house 40-313 (452) alignment 
Range on Protein: 157-442
Range on HMM: 40-313/452.0
LVHAKYVLLILREARERFRALPNVIRVTTRIakqmTICGDLHGKLDDLFMIFHKNGLPSpENPYIFNGDLVDRGPRSIEICIILFAFTILYPNGVYINRG
 .... .| |..|| . ..  .....| . |    |..||.||.  ||. .|. .| |. .  |.| || ||||  |||. . |.|  | ||. ... ||
rleeeaalkiieeaakllkkektlleveaPi....tviGdihGqfydllklfevgGdPa.stkylflGdyvdrGyfsiecvlylyalkiaypstlfllrG

NHEDHIMNLRYGFVKEVMDKYKDhasKIIRLFEDIFGWLPLATIVNNKIFVAHGGIS-NITDLDIIERIDRHKYVSVLKP-PNIVKDNPSlsslKEWrqv
||| . .   . | .|.  ||.    ..   . . |  ||||...|.. .  |||.| .|..|| |...|| | .    |  ...  .|     ...   
nhecrhlteyftfkeeckikyse...evydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPl....edy...

ldllwSDPKPTPGCKPNTFRGGGCYFGPDVTSQVLRKHNFELLVRSHECKYEGYEYMHN------KKVITIFSASNYYEQGSNRGAYMKIGPDM
     .. | .   .||. ||  ....   ... |.| ..  ..|.||.. .||.  ..        .||.|||.|| .  .|..| .|.  . 
.....geekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennv
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 166-456 2.5e-48 158.0 In-house 11-275 (284) alignment 
Range on Protein: 166-456
Range on HMM: 11-275/284.0
ILREARERFRALPNVIRVTTRIakqmTICGDLHGKLDDLFMIFHKNGLPSPENpYIFNGDLVDRGPRSIEICIILFAFTILYPNGVYINRGNHEDHIMNL
.| .| . |   | .| | . |     ||||.||.. ||. .| |||.|   | |.| || |||| . .|  ..|||. ...|| ... |||||  ..| 
llfhafsifnkqpmlievnspi....nicgdihgqfsdllrlfdkngfphran.ylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslink

RYGFVKEVMDKYKDHAskIIRLFEDIFGWLPLATIVNNKIFVAHGGISNItdldiIeridrhKYVSVLKPPNIVKDNPSLSSLkewrqVLDLLWSDPKPT
 ||| .|.  .|.  .  .   || .|  .||...| ..|.. |||.|..     .      . || |.  .   |||   .|      .|.|||||   
iygfyeecqrrynkps..vyvsfegvfsvmpltalvgqrilcmhggvskm.....l......qnvsqlraikrpfdnpepntl.....aidilwsdptnf

-PGCKPNTfRGGGCYFGPDVTSQVLRKHNFELLVRSHECKYEGYEYMHNKKVITIFSASNYYEQGSNRGAYMKIGPDMTPYFVqyqVSRTKK
  | .||. ||    || |   ..| . . .|.||.|.   .|||.. |....|||||  |  |  |  | | .  ..   ||   | | .|
qkgwnpns.rgvsyvfgsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfv...vlrprk
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 219-444 6.3e-48 156.5 In-house 102-307 (317) alignment 
Range on Protein: 219-444
Range on HMM: 102-307/317.0
PYIFNGDLVDRGPRSIEICIILFAFTILYPNGVYINRGNHEDHIMNLRYGFVKEVMDKYKdhaSKIIRLFEDIFGWLPLATIVNNKIFVAHGGISN-ITD
 |.| || ||||| |||. |.|||. .|||. |.. |||||   .| .||| .||  .|.   ...   |. .|  |||...||.||.  |||||. ..|
kylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrys...aalyeafqlafnvlplcavvnkkilcmhGGiseelld

LDIIERIDRhkyvsvlkpPNIVKDNPSLSslkewrqvlDLLWSDPKPTPGCKPNTFRGGGCYFGPDVTSQVLRKHNFELLVRSHECKYEGYEYMHNKKVI
|. .....|         |  . |   |.         || |.||...     .. || |  ||..   . |.|....|.||.|.   .|||.. ..|..
lkqldklkr.........pldipdvGvla.........dltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklv

TIFSASNYYEQGSNRGAYMKIGPDMTP
||||| .|  |  | .| ...  ... 
tifsapsycGqldniaavlsvdkklki
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 186-442 1.7e-45 148.4 In-house 32-267 (281) alignment 
Range on Protein: 186-442
Range on HMM: 32-267/281.0
RIAKQMTICGDLHGKLDDLFMIFHKNGLPsPENPYIFNGDLVDRGPRSIEICIILFAFTILYPNGVYINRGNHEDHIMNLRYGFVKEVMDKYkdhASKII
 | | ... ||||.. .||  .|.  | . ||. ..| || |||||.|.|. |.||.. | |.. ... |||||   .| .||| .| . ||     .. 
eidkPivvvGdlhaqfndlkrlfellgrv.peevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnkiygfyvecvtky...Geelw

RLFEDIFGWLPLATIVNNKIFVAHGGISN-ITDLDIIEridRHkyvsvlkpPNIVKdNPslsslkEWRQVLDLLWSDPKPTPGCKPNTFRGGGCYFGPDV
 ||.  |  ||... ..... ..|||.|  .| || .     .        |. .. |.      .   | ||||.||..      .. || .  || .|
alfqrcfnrlpisaliakrvlcmhGGlsPeltaldelr...nr........pkpir.nl......drGlviDllwadpdnkveewkassrGssftfGknv

TSQVLRKHNFELLVRSHECKYEGYEYMHNKKVITIFSASNYYEQGSNRGAYMKIGPDM
  .| .. . ||..|.|   ..||| .  .|.||.||. || ..  | .| .|.  ..
vddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetl
subfamily_PPP6C_pd Subfamily PPP6C 187-440 4.5e-45 147.0 In-house 40-272 (290) alignment 
Range on Protein: 187-440
Range on HMM: 40-272/290.0
IAKQMTICGDLHGKLDDLFMIFHKNGlPSPENPYIFNGDLVDRGPRSIEICIILFAFTILYPNGVYINRGNHEDHIMNLRYGFVKEVMDKYKDhaSKIIR
.   .|.|||.||.. ||  .|.. |   |.. |.| || ||||  |.|    |... . ||. . . ||||| . .   ||| .| ..|| .  ..  .
vsspvtvcgdihgqfydleelfrtgg.qvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqitqvygfydeclnkygn..anawk

LFEDIFGWLPLATIVNNKIFVAHGGIS-NITDLDIIERIDRHKYVSvlkppnivKDnPslsslkewrQVLDLLWSDPKPTPGCKpNTFRGGGCYFGPDVT
 . ..|  |..|.|......  |||.| ... || |. |.| . ..        ..            . ||.||||.     .  . || |  ||  ||
yctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeip........hk.g.........afcdlvwsdpedvetwa.vsprgagylfgskvt

SQVLRKHNFELLVRSHECKYEGYEYMHNKKVITIFSASNYYEQGSNRGAYMKIGP
.. ..  |..|..|.|.   ||..|| ..|..|..|| ||  .  |  . ...  
kefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaled
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 185-439 1.4e-44 145.4 In-house 29-287 (302) alignment 
Range on Protein: 185-439
Range on HMM: 29-287/302.0
TRIAKQMTICGDLHGKLDDLFMIFH----------KNGLPSPENPYIFNGDLVDRGPRSIEICIILFAFTILYPNGVYINRGNHEDHIMNLRYGFVKEVM
..|.  .|| ||.||. .||. |.           |      .. ..| || ||||..|||   ..||. .|||.   . ||||| . .|  ||| .|. 
aeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgnhetkainfaygfreele

DKY-KDHASKIIRLFEDIFGWLPLATIVNNKIFVAHGGISN-ITDLDIIERIDRhkyvsvlkP-PNIVKDnpSLSSLKEWRQVLDL-LWSDPKPTPGCKP
 .. | .  .| . |...| ..|||..| .||.  |||||. .. |. |..|.|        | ... .|  ||.    . . ||  |   .. .|  . 
nrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikr........plkevted..slaqdllfadpldvqllaavsekPkyak

NTFRGGGCYFGPDVTSQVLRKHNFELLVRSHECKYEGYEYMHNKKVITIFSASNYYEQGSNRGAYMKIG
|. ||    |      .| .. |..|.||.|    ||. .. .||..|||||..| ..  |.|| .|. 
nivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvd
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 185-439 1.8e-44 145.1 In-house 30-288 (302) alignment 
Range on Protein: 185-439
Range on HMM: 30-288/302.0
TRIAKQMTICGDLHGKLDDLFMIFH----------KNGLPSPENPYIFNGDLVDRGPRSIEICIILFAFTILYPNGVYINRGNHEDHIMNLRYGFVKEVM
..|.  .|| ||.||. .||. |.           |      .. ..| || ||||..|||   ..||. .|||.   . ||||| . .|  ||| .|. 
aeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgnhetkainfaygfreele

DKY-KDHASKIIRLFEDIFGWLPLATIVNNKIFVAHGGISN-ITDLDIIERIDRhkyvsvlkP-PNIVKDnpSLSSLKEWRQVLDL-LWSDPKPTPGCKP
 .. | .  .| . |...| ..|||..| .||.  |||||. .. |. |..|.|        | .....|  ||.    . . ||  |   .. .|  . 
nrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikr........plkevted..slaqdllfadpldvqllaavsekPkyak

NTFRGGGCYFGPDVTSQVLRKHNFELLVRSHECKYEGYEYMHNKKVITIFSASNYYEQGSNRGAYMKIG
|. ||    |      .| .. |..|.||.|    ||. .. .||..|||||..| ..  |.|| .|. 
nivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvd
subfamily_PPZ_pd Subfamily PPZ 158-439 4.2e-44 144.3 In-house 25-281 (300) alignment 
Range on Protein: 158-439
Range on HMM: 25-281/300.0
VHAKYVLLILREARERFRALPNVIRVTTriakQMTICGDLHGKLDDLFMIFHKNGLPsPENPYIFNGDLVDRGPRSIEICIILFAFTILYPNGVYINRGN
.. . .| |  .||| | | |... ..     .. | ||.||.  ||. .| | |.| | . |.| || |||| .|.|  ..|... | ||. ... |||
lknseilqicikarelflaqpallelsp....svkivgdvhgqyadllrlftkcgfp.psanylflgdyvdrgkqsletillllcykikypenffllrgn

HEDHIMNLRYGFVKEVMDKykdHASKIIRLFEDIFGWLPLATIVNNKIFVAHGGISNItdldiIERIDRHKYVSvlKPpnivKDNPSlsslkeWRQVLDL
||   .   |||  |.  .      || . | | |  ||||.||  |||. |||.| .     .. .|  ..|.  .|     | |       .  . ||
hecanvtrvygfydeckrr...cnikiwktfvdtfntlplaaivagkifcvhgglspv.....lnsmdeirhvv..rp....tdvpd......fglindl

LWSDPKPTPGCKPNTFRGGGCYFGPDVTSQVLRKHNFELLVRSHECKYEGYEYMHNKKVITIFSASNYYEQGSNRGAYMKIG
|||||  ..    .  ||    .      ..| |  |.|..|.|    .|||.. .. ..|.||| ||  .  | || | . 
lwsdptdssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvs
subfamily_PPG1_pd Subfamily PPG1 185-451 9.1e-43 139.6 In-house 37-295 (300) alignment 
Range on Protein: 185-451
Range on HMM: 37-295/300.0
TRIAKQMTICGDLHGKLDDLFMIFHKnGLPSPENPYIFNGDLVDRGPRSIEICIILFAFTILYPNGVYINRGNHEDHIMNLRYGFVKEVMDKYKDhASKI
 .|   .|. ||.||.. |.. ||.  | . |.  |.| || ||||  |.|  ..| .. . ||  . . |||||   .   |||  |...||    |..
ieirspvtvvgdvhgqfydvleifki.ggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitqvygfyteclrkygg.nsrv

IRLFEDIFGWLPLATIVNNKIFVAHGGIS-NITDLDIIERIDRHKYVsvlkpPnivkDNPSLSslkewrqvlDLLWSDPK----PT---PG----CKPNT
 . . .|| .| ||.|....|.. |||.| ..  .| |  .|| . |     |    .. .|.         |||||||.    ||   |        ..
wkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrev.....p....negala.........dllwsdpeennnptldhpdregqhfvvs

FRGGGCYFGPDVTSQVLRKHNFELLVRSHECKYEGYEYMHNKKVITIFSASNYYEQGSNRGAYMKIGPDMTPYFVQYQV
 || |  .| ||. . ||. ... ..|.|.   |||. . ..|. |..|| || ..  |. . ...      ||  |. 
qrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyee
Metallophos Calcineurin-like phosphoesterase 192-405 2.1e-41 135.4 Pfam-A 4-200 (200) alignment 
Range on Protein: 192-405
Range on HMM: 4-200/200.0
TICGDLHGKLDDL---FMIFHKNGLPSPENPYIFNGDLVDRGPRSIEICIIL--FAFTILYPNGVYINRGNHEDHIMNLRYGFVKEVMD-----------
...|||||.||||   ..|..|.. ... ....|.|||||||..|.|.  .|  ..  .|.|. |. .|||||.. .| .||| .|. .           
lvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangeee

--------------------KYKDHASKIIRLFEDIFGWLPLATIVNNKIFVAHGGISNITDLD--Iieridrhkyvsvlkppnivkdnpslsslkewrq
                    .|...  .. . ....| .|||...|..||...||..|  ...   |                                 
yenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi.................................

vldllwsdpkptpgckpntfrgGGCYFGPDVTSQVLRKHNFELLVRSHECKY
                      |...||||...  |.|..  |..|.|..|.
......................gselfgpdalekllekygvdlvlrGHtHkp
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 219-439 1.8e-39 128.8 In-house 121-321 (339) alignment 
Range on Protein: 219-439
Range on HMM: 121-321/339.0
PYIFNGDLVDRGPRSIEICIILFAFTILYPNGVYINRGNHEDHIMNLRYGFVKEVMDKYKdhaSKIIRLFEDIFGWLPLATIVNNKIFVAHGGISnitdl
 |.| || ||||| |.|. |.| |. . ||. .|. ||||| . .|  ||| .||  .|    ...   |...|  .|.....|| |.. |||||     
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyryd...aqlyecfqnmfnvfpfcavinntimcmhggis.....

diiERIDRHKYVSVLKPPNIVKDNPSLSslkewrqvlDLLWSDPKPTP-GCKPnTFRGGGCYFGPDVTSQVLRKHNFELLVRSHECKYEGYEYMHNKKVI
   |..   . .||.| |  . |   |.         || |.|| ||  | || . ||    |||     .|.| ......| |.   .|||..  ....
...ehltsfnqfsvfkrpleipdvgvlt.........dltwadpdptekgykp.sargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlv

TIFSASNYYEQGSNRGAYMKIG
||||| ||  |  |  | . | 
tifsapnycgqndntaavfsid
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 189-439 7.9e-39 126.6 In-house 47-279 (307) alignment 
Range on Protein: 189-439
Range on HMM: 47-279/307.0
KQMTICGDLHGKLDDLFMIFHKNGLPsPENPYIFNGDLVDRGPRSIEICIILFAFTILYPNGVYINRGNHEDHIMNLRYGFVKEVMDKYKDHASKIIRLF
    . |||||...||  .|   | | ||  |.| || ||||  |.|. ..||.. | ||. . . |||||   .| .||| .|..        .|  ||
ppcvvvgdlhgqfndlinmfillgrp.petvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfyeecvtsipkcgeeiwalf

EDIFGWLPLATIVNNKIFVAHGGISNItdLDIIERIDRHkyvsvlkpPNIVKdNPSLSSlkewrqVLDLLWSDPKPTPGCKPNTFRGGGCYFGPDVTSQV
.  |  ||.....  ||.. |||.|    |  .. .  |        |. .. ||          | |.||.|| |.      . || |  || .|  .|
qrcfnnlpisaliatkilcmhgglspa..ltcldelrnh........pkpir.npfrgi......vndmlwadpdpsvfewkassrgsgftfgtnviddv

LRKHNFELLVRSHECKYEGYEYMHNKKVITIFSASNYYEQGSNRGAYMKIG
 ..   ||..|.|.  ..||  .  .|.||||||  | .   | |. .|. 
ckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvd
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 190-448 7.3e-37 120.4 In-house 8-252 (263) alignment 
Range on Protein: 190-448
Range on HMM: 8-252/263.0
QMTICGDLHGKLDDLFMIFHKNGLPSpENPYIFNGDLVDRGPRSIEICIILFAFTILYPNGVYINRGNHEDHIMNLRYGFVKEVMDKYKDH--ASKIIRL
 . |||| ||. .||. ||   |  . .  |.| || |||| .|.|. ..||.. .  |  ... ||||| . .|  |||  |.  ...       .   
pinicgdthgqyndllrifnacgaat.ktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvynh

FEDIFGWLPLATIVNNKIFVAHGGISN-ITDLDIIERIdrhkyvsvLKPPNIVKDNPslsslkewrQVLDLLWSDP-KPTPGCKPNTFRGGGCYFGPDVT
|...| ..||..||...|.. |||||  .  || |  |          | .  |  |            ||||.|| | . | .||  |     ||    
fnqvfsymplcaivskrilcmhggisphlkslddirai........plpletakthp.........lacdllwadpekdakgfepnkiraisnvfgkkev

SQVLRKHNFELLVRSHECKYEGYEYMHNKKVITIFSASNYYEQGSNRGAYMKIGPDMTPYFVQ
 .. .. . .|.||.|.    || .. ....||.|||| |  .  |  | . .   .   |||
ddlckrldidlivrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvq
subfamily_PPPLV_pd Subfamily PPPLV 191-435 1.3e-35 116.1 In-house 26-272 (290) alignment 
Range on Protein: 191-435
Range on HMM: 26-272/290.0
MTICGDLHGKLDDLFM---IFHKNGLPSPENPYIFNGDLVDRGPRSIEICIILFAFTILYPNGVYINRGNHEDHIMNLRYGFVKEVMDKYKDHASKIIRL
. . |||||   || .    . . |       ..| || ||||. |.|.   |.|  .|||  |.. ||||| . .   . .  | . |. |.  ..   
tyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesieykgegsfkfgdsleevwea

FEDIFGWLPLATIVNNKIFVAHGGISNITDLD--------IIERIDrhkyvsvlkppnivkDNPSLSSlkewrQVLDLLWSDPKP------------TPG
| ..| .||||.....|.| .|.|| . .  .        |.||..               |.   .        ||.|||||.               |
fnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlk...............ddidgap.....laldilwsdpaedrdlslrgelvlneG

CKPNTFRGGGCYFGPDVTSQVLRKHNFELLVRSHECKYEGYEYMHNKKVITIFSASNYYeQGSNRGAY
  .|  || |. |. |   . |.. | . ..|.|| | .|... .. ...|.||.|.|   .||  | 
fvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssryc.Gssneaal
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 190-438 7.5e-35 113.7 In-house 34-261 (280) alignment 
Range on Protein: 190-438
Range on HMM: 34-261/280.0
QMTICGDLHGKLDDLFMIFHKNGLpSPENPYIFNGDLVDRGPRSIEICIILFAFTILYPNGVYINRGNHEDHIMNLRYGFVKEVMDKYkdhASKIIRLFE
 . . ||.| . .|.  .|   |   ||.  .| || |||||. ||. |.||.. | | . .|. |||||   .|  |||  |.  ||   .  .   |.
pikvigdihaqyqdmnrlfdligr.vpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygfyvecqyky...gvglwwdfq

DIFGWLPLATIVNNKIFVAHGGIS-NITDLDIIERIDRhkyvsvlkPPnivkdNPslssLkEWRQVLDLLWSDPKPTPGCKPNTFRGGGCYFGPDVTSQV
 .|  .|.. ........ |||.| .. .|| |  | |        |      .|    | .   ..|||||||         . ||    ||  |  | 
scfnrmpmsgliskrvlcmhgglspelinldtirnipr........pc.....ep....l.drgllidllwsdptnkgegwfhsirgisymfgkgvveqa

LRKHNFELLVRSHECKYEGYEYMHNKKVITIFSASNYYEQGSNRGAYMKI
 .  . .|..|.|.   .||| |  ...||.||  ||  | .|  | . .
cksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvcl
EF-hand_7 EF-hand domain pair 569-633 2.2e-16 49.7 Pfam-A 2-66 (66) alignment 
Range on Protein: 569-633
Range on HMM: 2-66/66.0
LETIFRLMDKDNSGHVSMEEFQASCRLLNQHSETEIPEDSIQDLARSIDMDKDGYIDFNEFLEAF
|...|.|.|||..|....||... .. |. .   |  ....... . || ..||...|.|||.|.
lkeaFkllDkdgdgyldkeeLlrllkhlgsplideevrevldyifkeiDkngdGvlsfeEflqai
subfamily_YNL217W_pd Subfamily YNL217W 184-314 1.7e-10 33.8 In-house 5-138 (235) alignment 
Range on Protein: 184-314
Range on HMM: 5-138/235.0
TTRIAKQMTICGDLHGKLDDLFMIFH-KNGLPSPENPYIFNGDLVDRGPRSIEICIILfaftilYPNGVYINRGNHEDHIMnLRYGFVKEVMdKYKDH--
 .  .|.. . || ||  |.|  ... |.|   ..   .. |||...||.|.|.   .        ..|.  .||||  .. |.| .||.    ....  
vdvlgkrllvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvl.laykwvkkpk.gaeplef

ASK---I-IRLFEDIFGW---LPLA-TIVNNKIFVAHGGISN
.||   .  .| ..   .   |. .  |  ....|.|.|.. 
sskfsflesklskadmeyarelgfsldipsdellvvhaGlvp
EF-hand_8 EF-hand domain pair 594-633 2.9e-09 25.7 Pfam-A 15-51 (54) alignment 
Range on Protein: 594-633
Range on HMM: 15-51/54.0
RLLNQHSeteIPEDSIQDLARSIDMDKDGYIDFNEFLEAF
.|| ...   . |. ...| | .|.|.||.|.|.||....
allglkg...lseeevdilfrefDtdgdGkisfeEFcvll
EF-hand_1 EF hand 610-634 1e-08 23.9 Pfam-A 3-27 (29) alignment 
Range on Protein: 610-634
Range on HMM: 3-27/29.0
QDLARSIDMDKDGYIDFNEFLEAFR
... . .| |.||.|.|.||.||..
keaFkefDkDgdGkIsfeEfkealk
EF-hand_1 EF hand 569-594 1.8e-08 23.1 Pfam-A 2-27 (29) alignment 
Range on Protein: 569-594
Range on HMM: 2-27/29.0
LETIFRLMDKDNSGHVSMEEFQASCR
|. .|...|||..|..| |||.. ..
lkeaFkefDkDgdGkIsfeEfkealk
PPP5 PPP5 TPR repeat region 112-183 3.5e-08 23.8 Pfam-A 23-95 (95) alignment 
Range on Protein: 112-183
Range on HMM: 23-95/95.0
SSTTLEAATDPSDIKVEPTYTGHVVK-LPITLMSVRNIIEQCKLNKLVHAKYVLLILREARERFRALPNVIRV
.  . ..  | ..|..|. |.|  .    .||  |....|. | .| .| |.|  || . .| ...||... .
ekrsvaesidiesieieddYdgprledekvtlefvkelleefkkqkklhkkfvyqilldvkellkklpslvei
EF-hand_5 EF hand 570-591 1.1e-07 20.3 Pfam-A 2-23 (25) alignment 
Range on Protein: 570-591
Range on HMM: 2-23/25.0
ETIFRLMDKDNSGHVSMEEFQA
. .|| .||...| .|.||...
kdtFrafDkNgDGkIsreELkr
EF-hand_6 EF-hand domain 569-594 3.1e-07 19.8 Pfam-A 2-27 (31) alignment 
Range on Protein: 569-594
Range on HMM: 2-27/31.0
LETIFRLMDKDNSGHVSMEEFQASCR
|. .|.|.|||..| .. ||... .|
lreaFklfDkdgdGkidaeELrkaLr
EF-hand_8 EF-hand domain pair 568-591 6.3e-07 18.2 Pfam-A 26-49 (54) alignment 
Range on Protein: 568-591
Range on HMM: 26-49/54.0
NLETIFRLMDKDNSGHVSMEEFQA
 ....||..| |..| .| ||| .
evdilfrefDtdgdGkisfeEFcv
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 156-215 1.2e-06 20.9 In-house 7-62 (317) alignment 
Range on Protein: 156-215
Range on HMM: 7-62/317.0
KLVHAKYVLLILREARERFRALPnvirVTTRIAKQMTICGDLHGKLDDLFMIFHKNGLPS
.|...| .. .   ||| |   |    .  ..   .||.||.||. .|| .... || | 
dlfkekelielcyrarelfwkep....lkleleapvtivGdihGqfedllalldlnGwpl
EF-hand_5 EF hand 615-630 1.2e-06 17.0 Pfam-A 7-22 (25) alignment 
Range on Protein: 615-630
Range on HMM: 7-22/25.0
SIDMDKDGYIDFNEFL
 .|...|| |.. |. 
afDkNgDGkIsreELk
IQ IQ calmodulin-binding motif 30-47 2.1e-06 16.6 Pfam-A 2-19 (21) alignment 
Range on Protein: 30-47
Range on HMM: 2-19/21.0
RSAVLIQNWFRRYRARLE
..|..|| ..|.|.|| .
kaaikIQaawRgylaRkr
EF-hand_9 EF-hand domain 570-633 3.1e-06 14.5 Pfam-A 1-62 (66) alignment 
Range on Protein: 570-633
Range on HMM: 1-62/66.0
ETIFRLMDKDNSGHVSMEEFQAscrLLNQHSETEIPEDSIQDLARSIDMDKD-GYIDFNEFLEAF
.|.|.. | .. | | . .  .   .| .    ...|  ...||...| |   . .|.. ||   
dtvFevcDtqktGeVpvsriid...yLravtaqspqesrLeelakllDPdgedasvdldtflrvm
EF-hand_6 EF-hand domain 614-634 8.9e-06 15.3 Pfam-A 7-27 (31) alignment 
Range on Protein: 614-634
Range on HMM: 7-27/31.0
RSIDMDKDGYIDFNEFLEAFR
. .| |.||.||..|.. |.|
klfDkdgdGkidaeELrkaLr