Gene ACP6 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP2
Subfamily ACP6
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP130_AA protein Get Run
NvecP130_AA_39-421 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_ACP6_pd Subfamily ACP6 42-422 2.1e-177 581.5 In-house 1-376 (376) alignment 
Range on Protein: 42-422
Range on HMM: 1-376/376.0
SYELVHAQIAFRHGARTPVYRLPemvgrgkGIDDVTWDKDvIMGDLPQTMIEFRVRNIDGGDQPE------YSPNIKKGGCICGELTKVGQQQTFDLGRT
|.||...|..||||||||...||       ....|.|||| ....||...|..||.|..|...||      |...|.|||...|.|||||.||.|||||.
sleLkqvqvvfrhGartPikslP.......qeeeveWdkd.lleslpdleidyrvtnlnGepkPeskieekykkeilkGGafkGqLtkvGmqqvfdLGrk

LQKRYIDDIKLLSPVFTPHEVYIRSTNVPRTIKSAKCVVAGLYGKENIQRVLHII--TRDEREDTILPNMSFCPLLTRWLRKIQASSiqkINLEGYAKDH
|.|||..|||.||..|.|.||||||||..||..||.|.|||||||..||..|.||  |..|.|....||...||||.|..|....|.   |.|.|...|.
LrkrYvedikfLsqefnpqevyiRstnieRtlesarclvaGLygkiiiqkelpiilytdeedeevlyPnrqrcpllsrayrsvrksa...islpGisedt

STIRNDLGITA-KNFFFVCFRDVMSAREAHGLFVDPILHDYWDMIDQHATEELVVVQCGnlGKRfARQDIIKASVGKFLDEIITRMNDKINGISPAqHKM
..|...|.|.. |...||..||...||.||.|.|.|||.|..|.|..||.|||||...|  |.| ....|.|.||||.|.||............|| .|.
kqiadvldiseekkldfvslrDniaArlaHnlkvppilkdvidliekhAveelvvlleg..gdr.pekeilklsvGkvlkeilenlekakekeipa.rkl

CLYSVHDTSISCLLTALGVFDNKWPDFASEVAFELYRNQDNKYFVKVLYQEKAQHLPGNNTDLCPFEKFKALLAPQM-TNDWQSQCIYEDE
.|||.|||....||.||||||.|||.||..|..|||......|||.||||||...|.|...||.|.||||||||... ..|....|..|||
rLysaHDttlmtLLlalgvFDdkWPpfaadvileLyedkageyfvrvlYqekelrlrgseedlvPlekFkallavlvlpkdyaaeCklede
0049226 Phosphoglycerate mutase-like 44-417 2e-70 230.6 In-house 2-340 (342) alignment 
Range on Protein: 44-417
Range on HMM: 2-340/342.0
ELVHAQIAFRHGARTPvyrlpemvgrgkgiddvtwdkdvimgdlpqtmiefrvrnIDGGDQPEYspNIKKGGCICGELTKVGQQQTFDLGRTLQKRYidd
.|...|. .|||.|||                                       .. |.  ..  | ...|| .|||| .|..| ..||| | |||   
kLkqvqvliRHGdRtP.......................................lakgpldfl..newfwgcglgeLTplGreqayelGrrlrkrY...

IKLLSPVFTPHEVYIRSTNVPRTIKSAKCVVAGLYGKENIQRV--------LHIITRDEREDTIL-PNMSFCPLLTRWLRKIQASSIQKINLEGYAKDHS
 .||.. ..|.|||.||..|.||..|| ...|||.. |.....        . ||| .|  ||.| .... || . ..|.....|.  .  || ...  .
lgllpstynpdevyvrssdvdRtlqSaqaflaGlfppeltpilvplldwqpipiitepesndtllllpydscpnfdkllkellkseevqlfleeildllk

TIRNDLGITAKNFFFVC--FRDVMSAREAHGLFVDPILHDywdmIDQHATEELVVVQCGNLGKRFARQDIIKASVGKFLDEIITRMNDKINGisPAQHKM
.. . ||.. ...  |   . | . .. |||| . | . .      .   ..|  . . ..  ..  ..| ... | .|.||. |....|.|  |  .|.
klskllglnlstlsdvadtlydlllyelahglplppwcsl....ftleelkalyaldllyyygigygeeiarlaggpllneilarleeaieg..psdlkl

CLYSVHDTSISCLLTALGVFDNKWPDFASEVAFELYRNQdNKYFVKVLYQEKA------QHLPGNnTDLCPFEKFKALLAPQMTNDWQSQC
 ||. ||| |  ||.|||.|| ..|..|| ..||||... ..|.|.|||...       ..|||   .|||...|| |... . .|....|
ylyfahdttiaallsalglfddqlPpyasnlvfElyecd.geyyVrvlynggvlslpvtlplpgc.dglcpldefkelvkkflpgdfeelC
0053031 Phosphoglycerate mutase-like 44-419 1.4e-69 227.9 In-house 2-341 (342) alignment 
Range on Protein: 44-419
Range on HMM: 2-341/342.0
ELVHAQIAFRHGARTPvyrlpemvgrgkgiddvT------------WdkdvimgdlpqtmiefrvrnidggdqpeyspnikkgGCICGELTKVGQQQTFD
||..... .|||||||                 .            .                                    .|  |||| .|..| ..
eLkqvivlvRHGaRtP.................lskgpldplnewfy....................................pcgageLTplGreqaye

LGRTLQKRYiddIKLLSPVFTPHEVYIRSTNVPRTIKSAKCVVAGLYGKENIQRV--------LHIITRDEREDTIL-PNMSFCPLLTRWLRKIQASSIQ
||| | |||    .||.. ..| |||.||..|.||..|| ...|||...|... .        . |.| .| .|..| ||.. || . ..| ...||.  
lGrrlrkrY...lgllpstynpdevyvrssdvdRtlqSAqaflaGlfppegtpilnpllgwqpipihtepessdalllpnydpcpafdkllkealaseev

KINLEGYAKDHSTIRNDLGITAKNFF--FVCFRDVMSAREAHGLFVDpilhDYWDMIDQHATEELVVVQCGNLGKRFARQDIIKASVGKFLDEIITRMND
|  || |..  ... ..||.|.....  .  . | . .. |||| .     ..... ..   . |  .   .. . .  ....|.. | .|.||. |...
kellerylellqklskglgltlsdlldlvsdlydlllyelahglplp....pwctlftleelkalyaldllyyyglgpgnelaklaggpllneilarlee

KINGisPAQHKMCLYSVHDTSISCLLTALGVFDNKWPDFASEVAFELYRNQdNKYFVKVLYQEK------AQHLPGNNTdLCPFEKFKALLAPQMTNDWQ
||.|  |  .|. ||. ||| |  ||.|||.||...|..|| ..||||... ..|.|.|||...       ..||| .  |||...|| |. . . .|..
kisg..pldlklylyfahdttiaallsaLglfddqlPpyasnlvfElyedp.geyyVrvlynggtlseplvlplpgcdg.lcplsefkelvkkllpgdfe

SQCiY
..| .
klC.l
0046349 Phosphoglycerate mutase-like 42-421 4.4e-69 226.5 In-house 4-394 (409) alignment 
Range on Protein: 42-421
Range on HMM: 4-394/409.0
SYELVHAQIAFRHGARTPVYRlpemvgrgkgiddvtwdkdvimgdlpqtmiefrvrnidggdqP-----------EyspnikKGGCICGELTKVGQQQTF
..||...|. ||||||||..                                                               |.| .|.|| .|..| .
gceLkqvqvlfRHGaRtPtkk..........................................lsflpnwpginwt......ngpcgagqLTplGreqay

DLGRTLQKRYIDdIKLLSPV--FTPHEVYIRSTNVPRTIKSAKCVVAGLYGKENIQRVL------------HII----TRDE---REDTILPNMSFCPLL
.||. | |||.| ..||..   ..|.|.|.||..|.||..|| ...|||.. .... |.             |.    . .|    .||.||. | || |
elGkrlrkrYvd.lgLlpsnslynpdeiyvrssdvdRtlqSAqaflaGlfpplggeivpllrqdlldppfqpipidtvpiseddalddtllppdslcpal

TRWLRKIQA--SSIQKI----------NLEGYAKDHSTIRNDLGITAKNFFFVC-------FRDVMSAREAHGLFVDpilhDYWDMIDQHATEELVVVQC
 ..|.. ..  | ....           |. ..   ... . |....... ..        . |..... ||||       ...|....   . |  .. 
dkllkenlkslsevleflvdealldlelldetkdllkklaerlnselpglnltdpldvasllydtllyetahglplp....pwcdlftpeelkvlaylad

GNLGKRFARQDIIKASVGKFLDEIITRMNDKINGISPA----QHKMCLYSVHDTSISCLLTALGVFD-----NKWPDFASEVAFELYRN-QDNKYFVKVL
   .  .   .. |.. | .|.||..|..|.|.| .|.    ..|. ||. ||| |  ||.|||.||      ..|..|| ..||||.. .|..|.|.||
leyyylygsgelaklaggpllneilarledaisgknpvtfpldlklylyfaHdttiaallsaLglfdrlfrssdippyasnlvfElyecpsdgeyyVrvl

YQEKAQHLPGNNTDlCPFEKFKALLAPQMTN----DWQSQCIYED
|... . |||...  ||...|| || . . .    |... | .||
ynggplplpgcgeg.cplsefkellkkrlpgcgltdfdklCpled
0047369 Phosphoglycerate mutase-like 40-417 1.5e-68 225.0 In-house 39-436 (438) alignment 
Range on Protein: 40-417
Range on HMM: 39-436/438.0
KCSYELVHAQIAFRHGARTP-----------------VYRLPEmvgrgkgiddvtwdkdvimgdlpqtmiefrvrnidggDQPEYSPNIKkGGCICGELT
  ..||...|. ||||||||                 .. .|                                      .. .. .. . | |  |.||
pegcelkqvqvlfRHGaRtPtksklkkleplwellenattyps.....................................gplsflndwl.gpcgagqLT

KVGQQQTFDLGRTLQKRYiddiKLLspvfTPHEV-YIRSTNVPRTIKSAKCVVAGLYGKENIQR-------VLHIITRDEREDTILP--NMSFCPLLTRW
 .|..| ..||. | |||    .||    .|..| |.||..|.||..|| ...|||.. |  .        . .|.|. |  |..|.  ... || .  .
plGreqayelGkrlrkrY....glL....npedvlyvrssdvdRtlqSAqaflaGlfppegtgelapilwqpipihtipesddfllnllpsdscpafdel

LRKIQA-SSIQKINLEGYAKDHSTIRNDLGITAKNFFFVCFR--DVMSAREAHGLFVDPI----LHDYWDMIDQHATEELvvVQCGNLGKrfarqDIIKA
|....| .. ... |. ..|  ... . |..|..... ..    . . |.. .||.  |       . .. . . | .|    .  . |.     .. |.
lkeflasdeflelllkdilkrlkkllpglnltpsdvldlydlcaydtlangyaglplspfcslftpeelevleyladlef..yylygygn.....elakl

SVGKFLDEIITRMNDKINGIS--------------PAQHKMCLYSVHDTSISCLLTALGVFDNKWP---------------------DFASEVAFELYRN
. | .|.||..|..|.||| |              | ..|. ||. ||| |  ||.|||.||..||                      .|| ..||||..
aggpllneilarledaingkstnlnltldsngvtfPldlklylyfaHdttiaallsaLglfddtwplpglpldkialnrlfrsseivPyasnlvfElyec

-QDNKYFVKVLYQEKAQHLPGNNTD---LCPFEKFKALLAPQMTNDWQSQC
 .|..|.|.|||..| ..||| ...   |||...|| |. . . .|....|
psdgeyyVrvlyngkvlplpgcgsgpgglCplddFkelvkkllpgdfeelC
0049059 Phosphoglycerate mutase-like 40-417 5.4e-68 222.9 In-house 38-434 (435) alignment 
Range on Protein: 40-417
Range on HMM: 38-434/435.0
KCSYELVHAQIAFRHGARTPVY-----------------RLPEmvgrgkgiddvtwdkdvimgdlpqtmiefrvrnidggdqpeySP----NIKKGGCIC
 ...||...|. ||||||||..                 . |                                           .|    |  .. . .
pegcelkqvqvlfRHGaRtPtsklikklealwekllslltypn..........................................gplsflndwnyplga

GELTKVGQQQTFDLGRTLQKRYiDDIkllspvFTPHEVYIRSTNVPRTIKSAKCVVAGLYGKE----------NIQRVLHIITRDEREDTIlpNMSFCPL
|||| .|..| ..||. | ||| ...      ..| |||.||..|.||..|| ...|||.. |          |.. ...| |.|.  ||.  ....|| 
geLTplGreqayelGkrlrkrY.gfL......ynpdevyvrssdvdRtlqSaqaflaGlfppeilgsqllnplnvyqpvpietvdsdndtl..pydscpa

LTRWLRKIQA-SSIQKINLEGYAKDHSTIRNDLGITAKNF---FFVCFRDVMSAREAHGLFVD---PILHDYWDMIDQHATEELVVVQC-GNlgkrfarq
.  .|....| .  ... || ..|  ... . ||.|....   ...|. |.. ...|||| ..    .  .... . . |  |       |.        
fdellkellasdeflelflerilkllqellpglgltpsdvldlydlckydtlllgyahglplpfcslfteeelevleyladlefyylygygd........

DIIKASVGKFLDEIITRMNDKINGISPA--------------QHKMCLYSVHDTSISCLLTALGVFDNKW----------------------PdFASEVA
.| |.. | .|.||. |..|.||| |.               ..|. ||. ||| |  ||.|||.||...                      | .|| ..
eiaklaggpllneilarledaingdstnlnltldsnpatfpldlklylyfaHdttiapllsaLglfddqlplpadntpfpeldrlfrtseivP.yasnlv

FELYRNQDN-KYFVKVLYQEKAQHLPGNNTD---LCPFEKFKALLAPQMTNDWQSQC
||||...|. .|.|.|||..| ..||| ...   |||...|| |. . . .|. ..|
fElyecpdgneyyVrvlyngkvlplpgcgsgpgglCplddFkelvkkflpgddfdeC
0048946 Phosphoglycerate mutase-like 41-421 1.1e-67 221.9 In-house 37-413 (447) alignment 
Range on Protein: 41-421
Range on HMM: 37-413/447.0
CSYELVHAQIAFRHGARTPVYRLPE----------------MVGRGKGIDD--VTW------DkdvimgdlpqtmiefrvrnidggdqpeyspnikkggC
...||...|. ||||||||..  ..                . |  ....|  ...      .                                    |
egcelkqvqvlfRHGaRtPtkkylkgleplldllknanvlelggdlsflndwkyqlkneplwp....................................c

ICGELTKVGQQQTFDLGRTLQKRYiddIKLLSpvfTPHEVYIRSTNVPRTIKSAKCVVAGLYGKE---NIQRVLHIITRDEREDTILPnmsFCPLLTRWL
  |.|| .|..| ..||. | |||    .||.   .|.|.|.||..|.||..|| ...|||...|   ..| .  ... .   .. ||    || .  .|
glgqLTplGreqlyelGkrlrkrY...lgllp...npseiyvrssdvdRtlqSaqaflaGlfppepplgyqpipihtvpssndnlllp...sCpafkell

RKIQASSIQKiNLEGYAKDHSTIRNDLGITAKNFFFVCfrDVMSA-REAHGL--FVDPILHDYWDMIDQHATeeLVVVQCGNLGKrfarqDIIKASVGKF
.| .|.....  |. ...  ... ..| .|..... ..  |.. . . .|||  . . .  .... . . |   |.  .. . |      .. ... | .
kkelaeelke.llkellerlkkllgglnltlsdvydly..dlllyetaihglsplcslftpeelevleylad..lefyyeygygd.....elarlaggpl

LDEIITRMNDKINGISpaqhKMCLYSVHDTSISCLLTALGVFDNKWP------------------DFASEVAFELYRNQ-----DNKYFVKVLYQEKAQH
|.||..|..|.|.| |    |. ||. ||| |  ||.|||.||...|                  ..|| ..||||...     |..|.|.|||... . 
lneilarledaisgds....klylyfaHdttiaallsaLglfddelplpadnlpfnrlfrsseivPyasnlvfElyecpsslpsdgeyyVrvlyngeplp

LPGNNTD---LCPFEKFKALLAPQMTnDWQSQCIYED
||| ...   |||...|| || . .  ||...| ...
lpgCgsgpgglCplddFkellkkflp.dweklCgltl
subfamily_ACP2_pd Subfamily ACP2 39-418 3.9e-62 202.9 In-house 3-357 (361) alignment 
Range on Protein: 39-418
Range on HMM: 3-357/361.0
EKCSYELVHAQIAFRHGARTPVYRLPEMVgrgkgiddvtwdkdvimgdlpqtmiefrvrnidggdqpeYSPN-IkKGGCicGELTKVGQQQTFDLGRTLQ
......|   |. ||||.|.|. ..|.                                         | .. .  .|   |.||. | || . ||. |.
sseerkLkfvqvlfRHGdRsPlntypndk.......................................ykedew.pqgl..GqLTeeGmqqqyeLGkfLr

KRYIDDIKLLSPVFTPHEVYIRSTNVPRTIKSAKCVVAGLYGKENIQ--------RVLHIITRDEREDTILPNMSFCPLLTRWLRKIQASSIQKINLEGY
|||..| |.|.. ..| ..|.||..| ||. || .|.|||...|. .        .   . |..| || .| ... ||     |.....|.  |  || .
krYvedtkfldakynpkqiyvrSsdvnRTlmSaqsvlaglfppetgvdypdeqeWqpvPvhtvseeedlllrakknCprydellqeakespevkklleen

AKDHSTIRNDLGITAKNFFFVCFRDVMSA-REAHG-LFVDPILHD-YWDMIDQHATEELVVVQcgNLGK---RfarqDIIKASVGKFLDEIITRMNDKIN
..  ... .  |.. ... |.   | .   |. .. | ... ..| ....... |..   . .  .|..   |    .. | . | .|.|....|..| .
kelleklsestgedidlenfyqlsdtlicerkyanelnlpewandelfekleeladkvkeaef..glnnektr....elkklrgGpllnellenmkeklk

-GISPAQHKMCLYSVHDTSISCLLTALGVFDNKWPDFASEVAFELYRNQDNKYFVKVLYQEKAQHLPG----NN---TDLCPFEKFKALLAPQMTNDWQS
   .. ..|. ||| ||| .  || |||.|..|.|..|| ...|||...|.|..|||||... .. |      .    ..|| .||| .. |  ..|...
ceekkkklklflYSaHDttlaalLeaLgifekkappyasaiivElyeeddgkplvkvlyrnetskdppeltlpgCkgeedCplskfkkivkpfipddvde

QCI
.| 
lCe
0048439 Phosphoglycerate mutase-like 42-406 1.4e-61 201.9 In-house 6-387 (391) alignment 
Range on Protein: 42-406
Range on HMM: 6-387/391.0
SYELVHAQIAFRHGARTPVYRLPEMVGRGKGIddvtwdkdvimgdlpqtmiefrvrnidggdqpeyspNIKKGGCICGELTKVGQQQTFDLGRTLQKRYI
..||...|. ||||||||.. .|..      .                                    .   |.| .|||| .|..| ..||| | |||.
gcelkqvqvlfRHGaRtPtssypnkldpllnk....................................llpngpcglgeLTplGreqlyelGrrlrkrYv

DdIKLLSPVF--TPHEVYIRSTNVPRTIKSAKCVVAGLYGKENIQRVLHIITRDEreDTILPN--MSFCPLLTRWLRKIQASSIQKINLE----------
|  .||.. .  .|.|||.||..|.||..|| ...|||.. .... .|.|....|  |..| .  . .||||   |.. . |.. .. |           
d.lgllpskytlnpsevyvrssdvdRtlqSAqaflaGlfpplgltvilvivvese..dpllnplpintcplledlllldalsalprfylseilerlaevl

-------GYAKDHSTIRNDLG-------------ITAKNFFFvcFRDVMSAREAHGLFVDPILHDywDMIDQHATEELVVV----QCGNLGKRfarqDII
        .|.|. .... ..              . ...|     |.. .. |||| . . | |  ..... . . |. .    . .. |      .| 
nrvlglnltaedvlslfdlcaketaalgsllklssplcdlft..lydtllyeyahglplpewltd..ellspellkqladlvnelyyyltgsg....eia

KASVGKFLDEIITRMndKINGisPAQHKMCLYSVHDTSISCLLTALGVFDN------KWPDFASEVAFELYRNQ-DNKYFVKVLYQEK------------
| . | .|.||....  ..||  | ..|. ||. ||| |  ||.|||.|..      ..|..|| ..||||... |..|.|.|||...            
klaggpllneilddl..vang..psdpklylyfaHdttiaallsaLglfndtlplpadlppyasnlvfElyecpsdgeyyVrvlynggtldlprdltlld

--------AQHLPGNNTD---LCPFEKFKALLA
         ..||| ...   |||...|..|. 
ldefllrlvlplpgcgsgpgglCplddFvelvk
subfamily_HP2-Group1_pd Subfamily HP2-Group1 47-418 8.9e-39 125.0 In-house 23-417 (422) alignment 
Range on Protein: 47-418
Range on HMM: 23-417/422.0
HAQIAFRHGARTPVyrlpEMVGRGKGIDDVTWDKDVIMGDLPQTMIEFRVRNIDGGDQPEYSPN--IKKGGCICGELTKVGQQQTFDLGRTLQKRYIDDi
 ...  ||| |          |     ||. || |.. ..|| .  | .   .|   .  | .    ..| |  ..|| .| .|    |..|.| |.|. 
qvivvirhGdrvra....aynGscwdGddaiwdcdlvsaslpvikvekerivvdriyrkiylntreedaGdcavaqltleGykqqelnGqilrkvyvdt.

KLLSPVFTPHEVYIRSTNVPRTIKSAKCVVAGLYGKENI----QRVLHIITRDEREDTILPNMSFCPLLTRWLRKIQASSIQKINLEGYAKDH-STIRND
 .| . . . |||.|| ...|||.||.... |.| .. .     .| .. |||.  |.| .|  .|| |. . ...  |.. .  |.| .|.    ... 
GflkssldssevylrsddesrtilsaqalilGmypqdtkaedraqvvdlytrdklfdsieanadlcpklseyntqflksdtwlnhlkgitkelllevska

LGITAK----NFFFVCFRDVMSAR----EAHGLFVDPILHDYWD--MIDQHATEELVV-------VQCGNLGKRFARQDIIKASVGKFLDEIITRMNDKI
||           .. .  .  .|    ..   .|| .   .     | .. ||.|.         .  .  |  ....  .. .| .| .|   .|. .
lGsnkslgsggcshtlylpiavtrkldidnledlvdclithqchnaaipdkltedlakrgldellyrsysslkypsvekyarvGiGfllkdiwkevnesl

NGISpaQHKMCLYSVHDTSISCLLTALGVFDNKWPDFASEVAFELYRNQ------DNKYFVKVLYQEKAQHLPGNNTDLCPFEKFKALLAPQMTNDWQSQ
.| .   .|. ||| |||..  ||.||.| . ||| .|| . .||.           .| |.|||. | ..||  ... |..|.|.| |.  . .|   .
tGed..lrkfllysGhdttliqllsalnvdefkwppyasllllellevstapaastpqyavrvlynGklkklpfcdanecsyeqfeaylstviphddaed

CI
| 
ck
His_Phos_2 Histidine phosphatase superfamily (branch 2) 44-381 2.8e-38 124.7 Pfam-A 1-346 (347) alignment 
Range on Protein: 44-381
Range on HMM: 1-346/347.0
ELVHAQIAFRHGARTPVYRLPEMVGRGKGIDDVTwdkdviM-------GDLPQTMIEfrvrnidggdqpeyspNIKKGGCICGELTKVGQQQTFDLGRTL
|| . .. .|||.|||.   .  |   | |. .       .       |. |.| ..                .  .  .  |.||. |..| ..||. |
eLkgvvvviRHGdRtPkqkfkksvtsekfisllk......lknvlekkghfpgtkrk................eklqlilkwgglThsGrkqaeelGeql

QKRYIddiKLLSPVFTPHEVYIRSTNVPRTIKSAKCVVAGLYGKEN------------IQRVLHIITRD---EREDTILPNMSFCPLLTR--W----LRK
 .||    .||.. .|...|.|||..  |...||... |||.|.|.             . .  .. ..   . .. .... . || ..   .      .
rqrYp...gllrdhltyedvkirssserRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellregaescpafawppikvekrvv

IQASSIQKINLEGYAKDHSTI-RNDLGITAKNFFFVCFRDVMSAREAHGLFVDPIlhdYWDMidqhATEELVVVQCGNLGKR----FARQDIIKASVGKF
 .  . .|.  | .||  | .   .  ...|.     ||. .  ...... .  .   |..|     .. | . |. .| .        . . ..  ...
elvnklkkvmdenlakrlsalctgednllfkerweklfreffeeekfdiskipel...ydtm....kydalhnrqledleelyklygigdeeklkiglll

LDEIITRMNDKINGIS-PAQHKMCLYSVHDTSISCLLTALGVFD------NKWPDFASEVAFELYRNQDNKYFVKVLY
| ... ........   . ..|. ||. ||. |  ||.|||...       .....|| . ||||. ...|..|..|.
lnpllkkilsdleetqpsrhaklrlyfthDshiytllnaLgleekiareaspelpyasqivfelyedsekkfyvrllf
His_Phos_2 Histidine phosphatase superfamily (branch 2) 44-381 2.8e-38 124.7 In-house 1-346 (347) alignment 
Range on Protein: 44-381
Range on HMM: 1-346/347.0
ELVHAQIAFRHGARTPVYRLPEMVGRGKGIDDVTwdkdviM-------GDLPQTMIEfrvrnidggdqpeyspNIKKGGCICGELTKVGQQQTFDLGRTL
|| . .. .|||.|||.   .  |   | |. .       .       |. |.| ..                .  .  .  |.||. |..| ..||. |
eLkgvvvviRHGdRtPkqkfkksvtsekfisllk......lknvlekkghfpgtkrk................eklqlilkwgglThsGrkqaeelGeql

QKRYIddiKLLSPVFTPHEVYIRSTNVPRTIKSAKCVVAGLYGKEN------------IQRVLHIITRD---EREDTILPNMSFCPLLTR--W----LRK
 .||    .||.. .|...|.|||..  |...||... |||.|.|.             . .  .. ..   . .. .... . || ..   .      .
rqrYp...gllrdhltyedvkirssserRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellregaescpafawppikvekrvv

IQASSIQKINLEGYAKDHSTI-RNDLGITAKNFFFVCFRDVMSAREAHGLFVDPIlhdYWDMidqhATEELVVVQCGNLGKR----FARQDIIKASVGKF
 .  . .|.  | .||  | .   .  ...|.     ||. .  ...... .  .   |..|     .. | . |. .| .        . . ..  ...
elvnklkkvmdenlakrlsalctgednllfkerweklfreffeeekfdiskipel...ydtm....kydalhnrqledleelyklygigdeeklkiglll

LDEIITRMNDKINGIS-PAQHKMCLYSVHDTSISCLLTALGVFD------NKWPDFASEVAFELYRNQDNKYFVKVLY
| ... ........   . ..|. ||. ||. |  ||.|||...       .....|| . ||||. ...|..|..|.
lnpllkkilsdleetqpsrhaklrlyfthDshiytllnaLgleekiareaspelpyasqivfelyedsekkfyvrllf
subfamily_PXYLP1_pd Subfamily PXYLP1 309-409 8e-17 52.5 In-house 295-403 (419) alignment 
Range on Protein: 309-409
Range on HMM: 295-403/419.0
KFLDEIITRMNDKINGISpaQHKMCLYSVHDTSISCLLTALGVFDNKWPDFASEVAFELYRN-QDNKYFVKVLYQEKAQ---------HLPGNNTDLCPF
 .| .|..||   |.| .  ..|. ||| ||  .. |. |||. . ... .|| ..|||||. ... |...|||. | .         .  ... ||||.
pllrdivsrmlkiieGvd..kekfvlysghDvtlrplvaaLglseartiayasrlvfelyrreaskeyylrvlynGkDvtqkvdfCegdskrskkdlCPl

EKFKALLAPQM
| .   .  ..
enlvrfvkkdy
subfamily_PXYLP1_pd Subfamily PXYLP1 42-216 1.1e-12 38.9 In-house 21-201 (419) alignment 
Range on Protein: 42-216
Range on HMM: 21-201/419.0
SYELVHAQIAFRHGARTPVYRLPEMVgRGKGIDDVTWDKDVIMgDLPQTMIEFRVRNIDGGDQP-EYS-----PN--IKKGGCICGELTKVGQQQTFDLG
 ..|. . .  ||| |||.. .|.   | .   |..  .. .. |  .....    .. |.|   . .     |    ....|  |.||..|  | ...|
gfkLkavlvvirhGDrtPlsdipksk.raeinCdlsaasknlv.dklksfldnssseasgsdfenkvgplkslPllpnheriCelgqLtqkGvvqhLevG

RTLQKRYIDDIKLL--SPVFTPHEVYIRSTNVPRTIKSAKCVVAGLYGKENIQrvlHIITRDEREDTILPNMSFCP-LLTRWLRKI
  |.| |    |||     ..  ||.. .|.  ||..||  .. ||. |....    |  |.. . .   ..  || || . | | 
dllrkvYakklklLlkpnelssDevvlettrkrrtlqsalallygllpkaklk...airvrespsvafClgeCsCPallrkrleke
subfamily_MINPP1_pd Subfamily MINPP1 24-209 8.1e-09 26.8 In-house 11-181 (420) alignment 
Range on Protein: 24-209
Range on HMM: 11-181/420.0
AFRKIQSSRFT-TFASEKCsyELVHAQIAFRHGARTPVYRLPEM-VGRGKGIDDVTWDKDvIMGDLPQTMIEfrvrnidggdqpeysPNIKKGGCICGEL
........ .  . | |.|  .||. || .||| | |  .  .    . . |.. .   |  .  . .. .|                |..    . ..|
pyysvkanydikkeaeegC..klvklqiiaRHGtRypskskikkiqetlekiknyseqld.gklsilnedle...............snleyeteleksl

TKVGQQQTFDLGRTLQKRYIDdikLLSPVFTPHEVYIRSTNVPRTIKSAKCVVAGLYGKENIQRVLHIITR----DEREDTILPNMSFCPLL
.. ||..   |.. |..|. .   |.. |  | .....||.  ||.|||.  . || .....  .   |.     .. .| .|  .. |.  
vaqgqeeleelakrlarrfpa...lfeevynpdsfsfastakkRtvksaqaFaeGLsetgevlgdefnivlqeiseqesdklLrffdsCkky
subfamily_MINPP1_pd Subfamily MINPP1 359-418 9.2e-06 16.7 In-house 353-415 (420) alignment 
Range on Protein: 359-418
Range on HMM: 353-415/420.0
FASEVAFELYRNQDNKYFVKVLYQEKAQHLPGN--NTDLCPFEKFKALLAPQM-TNDWQSQCI
.|...||.||  . ..| |.|| .||. .|..   . ..|. ..|| ... ..   |... | 
yaanlafvlydCskdqykvlvllnekvvkletcsegeifCelqdfkeiykkivdncdleklCe