Gene NvecHP2-Un-1 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP2
Subfamily HP2-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP131_AA protein Get Run
NvecP131_AA_23-445 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_HP2-Group1_pd Subfamily HP2-Group1 24-445 1.5e-265 872.1 In-house 1-422 (422) alignment 
Range on Protein: 24-445
Range on HMM: 1-422/422.0
PEYCGKPTEAKTLGLPEGFKLKQTHVIIRHGDRVRAAYHGPCWDGDKAIWDCTLTSASLPAIKHDSHYIVVDRIYRRGYLNGRESDAGDCAIGHLTLEGY
||||||.||||.|||||..||||..|.|||||||||||.|.|||||.|||||.|.|||||.||.....||||||||..|||.||.||||||...||||||
peycGktteakslglpedvklkqvivvirhGdrvraaynGscwdGddaiwdcdlvsaslpvikvekerivvdriyrkiylntreedaGdcavaqltleGy

KQQELNGQILRKVYVDTGFLKSNFSSTEMYLRSDDESRTMQSAQALILGMYPPATIASDRAQVADINTMDKLFDSIEPNTMLCPKLSEYNHGFLKTDMWR
||||||||||||||||||||||...|.|.||||||||||..|||||||||||..|.|.|||||.|..|.||||||||.|..|||||||||..|||.|.|.
kqqelnGqilrkvyvdtGflkssldssevylrsddesrtilsaqalilGmypqdtkaedraqvvdlytrdklfdsieanadlcpklseyntqflksdtwl

HHYNGITKPLLLEVQKALGSNKTLGSGGCSHTLYLPIAVTRKLDIDGLDDLVDCIHTHQCHGFAIPPGITDDLFKRMVDELLYRWNSMYLYPSREKYATV
.|..||||.|||||.|||||||.|||||||||||||||||||||||.|.|||||..|||||..|||...|.||.||..||||||..|...|||.||||.|
nhlkgitkelllevskalGsnkslgsggcshtlylpiavtrkldidnledlvdclithqchnaaipdkltedlakrgldellyrsysslkypsvekyarv

GIGFLIKDIWQEVMESLTGESLRKFLLYSGHDGTIQPFLSAFNVTDFKWPPYASFLMLEILEVTGTPQASTPQYAVRMLYNGELLKFPFCDANPCPMDQF
|||||.||||.||.||||||.|||||||||||.|....|||.||..||||||||.|.||.|||...|.|||||||||.||||.|.|.||||||.|...||
GiGfllkdiwkevnesltGedlrkfllysGhdttliqllsalnvdefkwppyasllllellevstapaastpqyavrvlynGklkklpfcdanecsyeqf

EAYVNTIIPHNPAEDCKVSDPE
|||..|.|||..||||||||.|
eaylstviphddaedckvsdne
0049059 Phosphoglycerate mutase-like 29-440 2.3e-68 224.1 In-house 28-435 (435) alignment 
Range on Protein: 29-440
Range on HMM: 28-435/435.0
KPTEAKTLGLPEGFKLKQTHVIIRHGDRVRAAyhgPCWDGDKAIWDCTLTSASLPAikhdshyivvdriyrrgylngreS-------DAGDCAIGHLTLE
.   . .|..|||..|||..|..|||.|   .    .... .|.|.. | ..  |                        .         ...  |.|| .
pgvfgisldvpegcelkqvqvlfRHGaRtPts...klikklealwekllslltypn.......................gplsflndwnyplgageLTpl

GYKQQELNGQILRKVYvdtGFLksnFSSTEMYLRSDDESRTMQSAQALILGMYPPATIA------SDRAQVADINTMDKLFDSIepNTMLCPKLSEYNHG
|..|.   |. ||| |   |||   .. .|.|.||.|. ||.|||||.. |..|| ..           |.  |.|.| ..|..  ..  ||.. |. ..
GreqayelGkrlrkrY...gfL...ynpdevyvrssdvdRtlqSaqaflaGlfppeilgsqllnplnvyqpvpietvdsdndtl..pydscpafdellke

FLKTDMWRHHYNGITKPLLLEVQKALGSNKTLGSGGCSHTLYlpiavtrkldidglddlvDCIHTHQCHGFAIP--PGITDDLFKRMVdeLLYRWNSMYL
.|..| .  ...  .. || |. . || . .  .  .. ..|                  |.......||.  |  . .|.......    |. .   ||
llasdeflelflerilkllqellpglgltpsdvldlydlcky..................dtlllgyahglplpfcslfteeelevle..yladlefyyl

YPSREKYATVGIGFLIKDIWQEVMESLTGES----------------LRKFLLYSGHDGTIQPFLSAFNVTDFKWP---------------------PYA
|    ..|..  | |...| .   . . |.|                 .|. ||..||.||.|.|||....| ..|                     |||
ygygdeiaklaggpllneilarledaingdstnlnltldsnpatfpldlklylyfaHdttiapllsaLglfddqlplpadntpfpeldrlfrtseivPya

SFLMLEILEVtgtpqASTPQYAVRMLYNGELLKFPFCDANP---CPMDQFEAYVNTIIPHNPAEDCK
| |..|..|       ....| ||.||||. |..|.|. .|   ||.|.|  .|....|..  . |.
snlvfElyec.....pdgneyyVrvlyngkvlplpgcgsgpgglCplddFkelvkkflpgddfdeCg
0047369 Phosphoglycerate mutase-like 31-440 1.5e-67 221.6 In-house 31-437 (438) alignment 
Range on Protein: 31-440
Range on HMM: 31-437/438.0
TEAKTLGLPEGFKLKQTHVIIRHGDRVRaayHGPCWDGDKAIWDCTLTSASLPAikhdshyivvdriyrrgylngresDA--------GDCAIGHLTLEG
  . .|..|||..|||..|..|||.|      . ....   .|.. . .. .|                         .         | |  |.|| .|
vglisldvpegcelkqvqvlfRHGaRtP...tksklkkleplwellenattyps........................gplsflndwlgpcgagqLTplG

YKQQELNGQILRKVYvdtGFLksnfSSTEM-YLRSDDESRTMQSAQALILGMYPPATI---ASDRAQVADINTMDKLFDSIEP--NTMLCPKLSEYNHGF
..|.   |. ||| |   |.|    .. .. |.||.|. ||.|||||.. |..|| .    | .. |...|.|. .  |.. .  ..  ||...|. ..|
reqayelGkrlrkrY...glL....npedvlyvrssdvdRtlqSAqaflaGlfppegtgelapilwqpipihtipesddfllnllpsdscpafdellkef

LKTDMWRHHYngiTKPLLLEVQKALGsnktlgsggcshtlylpiavTRKLDIDGLDDLVDC--IH--THQCHGFAIPP---GITDDLFKRMvdELLYRWN
| .| .  ..   .|..|  ..| |.                    . .|... . || |.  .     ...|.  .|    .|..... .  | |. . 
lasdeflell...lkdilkrlkkllp....................glnltpsdvldlydlcaydtlangyaglplspfcslftpeelevl..eyladle

SMYLYPSREKYATVGIGFLIKDIWQEVMESLTGES----------------LRKFLLYSGHDGTIQPFLSAFNVTDFKWP--------------------
 .||| . ...|.. .| |...| .   . ..|.|                 .|. ||..||.||...|||....|..||                    
fyylygygnelaklaggpllneilarledaingkstnlnltldsngvtfPldlklylyfaHdttiaallsaLglfddtwplpglpldkialnrlfrssei

-PYASFLMLEILEVTgtpqaSTPQYAVRMLYNGELLKFPFCDANP---CPMDQFEAYVNTIIPHNPAEDCK
 |||| |..|..| .     |. .| ||.||||. |..|.|. .|   ||.|.|  .|....|.. .| |.
vPyasnlvfElyecp.....sdgeyyVrvlyngkvlplpgcgsgpgglCplddFkelvkkllpgdfeelCg
0049226 Phosphoglycerate mutase-like 43-439 3.9e-67 219.8 In-house 2-340 (342) alignment 
Range on Protein: 43-439
Range on HMM: 2-340/342.0
KLKQTHVIIRHGDRVraayhgPCWDGDKAIWDCTLtsaslpaikhdshyivvdriyrrgylngresdaGDCAIGHLTLEGYKQQELNGQILRKVYvdTGF
||||..|.||||||       | . |... .  ..                                 ..| .|.|| .|..|.   |. |||.|  .|.
kLkqvqvliRHGdRt......Plakgpldflnewf.................................wgcglgeLTplGreqayelGrrlrkrY..lgl

LKSNFSSTEMYLRSDDESRTMQSAQALILGMYPPATIASD----RAQVADINTMDKLFDSIE-PNTMLCPKLSEYNHGFLKTDMWRHHYNGItKPLLLEV
| |.....|.|.||.|..||.|||||.. |..|| .. ..    . |. .| |... .|..  .. . ||..... . .||.. .  ... | ..|| ..
lpstynpdevyvrssdvdRtlqSaqaflaGlfppeltpilvplldwqpipiitepesndtllllpydscpnfdkllkellkseevqlfleei.ldllkkl

QKALGSNktlgsggcshtlylpiavtrkL-DIDGLDD-LVDCIHTHQCHGFAIPPGITDDLFKRMVDELLYRWNSMYLYPSREKYATVGIGFLIKDIWQE
 | || |                     | ..  . | |.|..  ...||. .|| ....... .     . .  .|.. . |..| . .| |...| . 
skllgln.....................lstlsdvadtlydlllyelahglplppwcslftleelkalyaldllyyygigygeeiarlaggpllneilar

VMESLTGESLRKFLLYSGHDGTIQPFLSAFNVTDFKWPPYASFLMLEILEVTgtpqastPQYAVRMLYNGEL------LKFPFCdANPCPMDQFEAYVNT
. | . | | .|. ||..||.||...|||....| ..||||| |..|..| .        .| ||.||||.       |..|.|  . ||.|.|  .|..
leeaiegpsdlklylyfahdttiaallsalglfddqlPpyasnlvfElyecd.......geyyVrvlynggvlslpvtlplpgc.dglcpldefkelvkk

IIPHNPAEDC
..|.. .| |
flpgdfeelC
0048946 Phosphoglycerate mutase-like 24-445 3.2e-66 217.0 In-house 22-415 (447) alignment 
Range on Protein: 24-445
Range on HMM: 22-415/447.0
PEYCGKPTEAKTLgLPEGFKLKQTHVIIRHGDRVRAAYHGPCW----------------------DGDKAIWDCTLTSAslpaikhdshyivvdriyrrg
| .. .. .  .  .|||..||| .|..|||.|   .  .. .                      . .|. ...  .                       
pyfsvpgygipep.vpegcelkqvqvlfRHGaRtPtkkylkgleplldllknanvlelggdlsflndwkyqlkneplwp.....................

ylngresdagdCAIGHLTLEGYKQQELNGQILRKVYvdTGFLKsnfSSTEMYLRSDDESRTMQSAQALILGMYPPAtiASDRAQVADINT-MDKLFDSIE
           |  | || .|..|.   |. ||| |  .|.|    ...|.|.||.|..||.|||||.. |..||    ....|   | | ..  ...  
...........cglgqLTplGreqlyelGkrlrkrY..lgllp...npseiyvrssdvdRtlqSaqaflaGlfppe..pplgyqpipihtvpssndnlll

PntmLCPKLSEYNHGFLKtDMWRHHYNGITKPLLLEVqkalgsnktlgsggcshtlylpiAvTRKLDIDGLDDLVDCIHT-HQCHGFAIPPGI-TDDLFK
|    ||.. |.  ..|. ..... .. ... |   .                         . .|... . || |..   ...||   .... |.....
p...sCpafkellkkela.eelkellkellerlkkll.......................g.glnltlsdvydlydlllyetaihglsplcslftpeele

RMvdELLYRWNSMYLYPSREKYATVGIGFLIKDIWQEVMESLTGESlrKFLLYSGHDGTIQPFLSAFNVTDFKWP------------------PYASFLM
..  | |. .   |.|   ...| .  | |...| .   . . |.|  |. ||..||.||...|||....|...|                  |||| |.
vl..eyladlefyyeygygdelarlaggpllneilarledaisgds..klylyfaHdttiaallsaLglfddelplpadnlpfnrlfrsseivPyasnlv

LEILEVTGTpQASTPQYAVRMLYNGELLKFPFCDANP---CPMDQFEAYVNTIIPhNPAEDCKVSDPE
.|..| ...   |. .| ||.||||| |..|.|. .|   ||.|.|  ......| . .. |......
fElyecpss.lpsdgeyyVrvlyngeplplpgCgsgpgglCplddFkellkkflp.dweklCgltlsv
0046349 Phosphoglycerate mutase-like 38-443 5.6e-66 216.3 In-house 2-394 (409) alignment 
Range on Protein: 38-443
Range on HMM: 2-394/409.0
LPeGFKLKQTHVIIRHGDRVRAAY-------HGPCWDgdkaiwdctltsaslpaikhdshyivvdriyrrgylngresdAGDCAIGHLTLEGYKQQELNG
.| | .|||..|..|||.|   ..       .| .|                                            |.| .|.|| .|..|.   |
vP.gceLkqvqvlfRHGaRtPtkklsflpnwpginwt..........................................ngpcgagqLTplGreqayelG

QILRKVYVDTGFLKSN--FSSTEMYLRSDDESRTMQSAQALILGMYPPATIA---------------SDRAQVADINTMDKLFDSIEPNTMLCPKLSEYN
. ||| |||.|.| ||  ....|.|.||.|. ||.|||||.. |..|| ..                    ....|...| | | . |. .|||.| .. 
krlrkrYvdlgLlpsnslynpdeiyvrssdvdRtlqSAqaflaGlfpplggeivpllrqdlldppfqpipidtvpiseddalddtllppdslcpaldkll

HGFLKT-DMWRHHYNGITKPllleVQKALGSNKTLGSGGCSHTLYLpiavTRKLDIDGLDD----LVDCIHTHQCHGFAIPPG---ITDDLFKRMVDelL
. .||. . .   . ... .     .. |. .|.| .   ... .       .|.. ...|    | |..  ...||. .||    .|....|.. .  |
kenlkslsevleflvdeall....dlelldetkdllkklaerlnse....lpglnltdpldvasllydtllyetahglplppwcdlftpeelkvlay..l

YRWNSMYLYPSReKYATVGIGFLIKDIWQEVMESLTGES------LRKFLLYSGHDGTIQPFLSAFNVTD-----FKWPPYASFLMLEILEVtgtpqAST
...   ||| |. ..|..  | |...| .   . ..|..       .|. ||..||.||...|||....|      ..||||| |..|..|       |.
adleyyylygsg.elaklaggpllneilarledaisgknpvtfpldlklylyfaHdttiaallsaLglfdrlfrssdippyasnlvfElyec.....psd

PQYAVRMLYNGELLKFPFCDANpCPMDQFEAYVNTIIPH----NPAEDCKVSD
 .| ||.||||. |..| |.   ||...|  ... ..|.    . .. |...|
geyyVrvlynggplplpgcgeg.cplsefkellkkrlpgcgltdfdklCpled
0053031 Phosphoglycerate mutase-like 43-439 3.4e-65 213.6 In-house 2-340 (342) alignment 
Range on Protein: 43-439
Range on HMM: 2-340/342.0
KLKQTHVIIRHGDRVRAAYHGPC------WdgdkaiwdctltsaslpaikhdshyivvdriyrrgylngresdagDCAIGHLTLEGYKQQELNGQILRKV
.|||..|..|||.|   ...         .                                             .|  |.|| .|..|.   |. |||.
eLkqvivlvRHGaRtPlskgpldplnewfy.............................................pcgageLTplGreqayelGrrlrkr

YvdTGFLKSNFSSTEMYLRSDDESRTMQSAQALILGMYPPATIASDR----AQVADINTMDKLFDSIE-PNTMLCPKLSEYNHGFLKTDMWRHHYNGITK
|  .|.| |.....|.|.||.|. ||.|||||.. |..|| .. ..      |. .| |... .| .  || . ||..... ...|... .  ... ...
Y..lgllpstynpdevyvrssdvdRtlqSAqaflaGlfppegtpilnpllgwqpipihtepessdalllpnydpcpafdkllkealaseevkelleryle

pLLLEVQKALGSNktlgsggcshtlylpiavtrkldIDG----LDDLVDCIHTHQCHGFAIPPGITDDLFKRMVDELLYRWNSMYLYPSREKYATVGIGF
 || .. | || .                       ...    . ||.|..  ...||.  || .|.......     . .  .| . . ...| . .| 
.llqklskglglt.......................lsdlldlvsdlydlllyelahglplppwctlftleelkalyaldllyyyglgpgnelaklaggp

LIKDIWQEVMESLTGESLRKFLLYSGHDGTIQPFLSAFNVTDFKWPPYASFLMLEILEVTgtpqastPQYAVRMLYNGE------LLKFPFCDAnPCPMD
|...| .   | . |.. .|. ||..||.||...|||....| ..||||| |..|..| .        .| ||.||||.       |..|.||   ||..
llneilarleekisgpldlklylyfahdttiaallsaLglfddqlPpyasnlvfElyedp.......geyyVrvlynggtlseplvlplpgcdg.lcpls

QFEAYVNTIIPHNPAEDC
.|  .|....|.. .. |
efkelvkkllpgdfeklC
0048439 Phosphoglycerate mutase-like 38-432 1.3e-64 211.9 In-house 3-391 (391) alignment 
Range on Protein: 38-432
Range on HMM: 3-391/391.0
LPEGFKLKQTHVIIRHGDRVRAAYHGPCWDgdkAIWDCtltsaslpaikhdshyivvdriyrrgylngrESDAGDCAIGHLTLEGYKQQELNGQILRKVY
.|.| .||| .|..|||.|   .  . ..|    ....                                   |.|  |.|| .|..|.   |. ||| |
vpagcelkqvqvlfRHGaRtPtssypnkld...pllnk...............................llpngpcglgeLTplGreqlyelGrrlrkrY

VDTGFLKSNF--SSTEMYLRSDDESRTMQSAQALILGMYPPATiaSDRAQVADINTMDKLFDSIEPNTMLCPKlsEYNHGFLKTDMWRHHYNGITkPLLL
||.|.| |..  . .|.|.||.|. ||.|||||.. |..|| .   .   | .....| |. ..  ||  ...   .   .  . ..|.... |. . | 
vdlgllpskytlnpsevyvrssdvdRtlqSAqaflaGlfpplg..ltvilvivvesedpllnplpintcplle..dlllldalsalprfylseil.erla

EVQKA-LGSNKTLgSGGCSH-------TLYLPIAVTRKLDIDGLDDLVDCIHTHQCHGFAIPPGITDDL-----FKRMVDELLYRWNSMYLYPsreKYAT
||..  ||.|.|. .  .|        | .|   ...  ..  | .| |.. ....||. .|. .||.|     .| ..|   . .. .. ..   ..|.
evlnrvlglnlta.edvlslfdlcaketaalgsllklssplcdlftlydtllyeyahglplpewltdellspellkqladlvnelyyyltgsg...eiak

VGIGFLIKDIWQEVmeSLTGESLRKFLLYSGHDGTIQPFLSAFNVTDF------KWPPYASFLMLEILEVtgtpqASTPQYAVRMLYNGE----------
. .| |...| .      .|.| .|. ||..||.||...|||......      ..||||| |..|..|       |. .| ||.||||.          
laggpllneilddl..vangpsdpklylyfaHdttiaallsaLglfndtlplpadlppyasnlvfElyec.....psdgeyyVrvlynggtldlprdltl

----------LLKFPFCDANP---CPMDQFEAYVNTIIP
          .|..|.|. .|   ||.|.| ..|...||
ldldefllrlvlplpgcgsgpgglCplddFvelvkkrip
subfamily_ACP2_pd Subfamily ACP2 41-443 3.1e-51 167.0 In-house 6-360 (361) alignment 
Range on Protein: 41-443
Range on HMM: 6-360/361.0
GFKLKQTHVIIRHGDRVRA-AYHGPCwdgdkaiwdctltsaslpaikhdshyivvdriyrrgylngR-ESDAgDCAIGHLTLEGYKQQELNGQILRKVY-
  |||  .|..|||||     |.                                             |..  .  .|.|| ||..||   |..||| | 
erkLkfvqvlfRHGdRsPlntypndk........................................ykedew.pqglGqLTeeGmqqqyeLGkfLrkrYv

VDTGFLKSNFSSTEMYLRSDDESRTMQSAQALILGMYPP-ATI-AS--DRAQVADINTMDKLFDSIEPNTMLCPKLSEYNHGFLKTDMWRHHYNGITKpL
.||.||.........|.|| |  ||..|||... |..||   .  .   . |   . | ..  | .  .   ||.  |    . ... .. . .  .. |
edtkfldakynpkqiyvrSsdvnRTlmSaqsvlaglfppetgvdypdeqeWqpvPvhtvseeedlllrakknCprydellqeakespevkklleenke.l

LLEVQKALGsnK--TLGsggcshtlylpiavtrkLDIDgLDDLVDCIHT-HQChgFAIPPGITDDLFKRMVDELLYRWNSMYL--YPSREKYATVGIGFL
| ....  |  .  .|                   ... | | . |    ...  . .|. ..|.||...     .. . ..       .... . .|.|
leklsestg..edidle.................nfyq.lsdtlicerkyane..lnlpewandelfekleeladkvkeaefglnnektrelkklrgGpl

IKDIWQEVMESLT---GESLRKFLLYSGHDGTIQPFLSAFNVTDFKWPPYASFLMLEILEVtgtpqaSTPQYAVRMLYNGELL------KFPFCD-ANPC
.... ... | |.    .. .|..|||.|| |. ..|.|..... |.||||| .. |. |       .. .. |..||. |        ..|.|   . |
lnellenmkeklkceekkkklklflYSaHDttlaalLeaLgifekkappyasaiivElyee......ddgkplvkvlyrnetskdppeltlpgCkgeedC

PMDQFEAYVNTIIPHNPAEDCKVSD
|...|. .|...|| .. | |....
plskfkkivkpfipddvdelCeakt
subfamily_ACP6_pd Subfamily ACP6 42-443 5.7e-39 125.8 In-house 2-375 (376) alignment 
Range on Protein: 42-443
Range on HMM: 2-375/376.0
FKLKQTHVIIRHGDRVRAaYHGPcwDGDKAIWDCTlTSASLPAIKHDSHYIVVDRIYRRG----YLNGRESDAGDCAIGHLTLEGYKQQELNGQILRKVY
..|||  |. ||| |    .. |  . ... ||      ||| .. | .   ..   .          .|   | .  |.||  | .|    |. ||| |
leLkqvqvvfrhGartPi.kslP..qeeeveWdkd.lleslpdleidyrvtnlnGepkPeskieekykkeilkGGafkGqLtkvGmqqvfdLGrkLrkrY

VD-TGFLKSNFSSTEMYLRSDDESRTMQSAQALILGMYPPAtIAsDRAQVADINTMDKLFDSIEPNTMLCPKLSEYNHGFLKTDmwrHHYNGITKPLlLE
|.  .||  .|.. |.|.|| . .||..||. |. |.|    |. ..     . | ..  . . ||   ||.||.. ..  |.     . .||.. .  .
vedikfLsqefnpqevyiRstnieRtlesarclvaGLygki.ii.qkelpiilytdeedeevlyPnrqrcpllsrayrsvrksa...islpGisedt.kq

VQKALGSNKTlgsggcshtlylpiavtRKLDIDGlddLVDCIHTHQCHGFAIPPgITDDLFkRMVDELLYRwNSMYLYP--SR--EKYATVGIGFLIKDI
... |. ..                   |||  .   | | |  .. |.  .|| |. |.. .....   . ....| .   |  ..   . .| ..|.|
iadvldisee.................kkldfvs...lrDniaArlaHnlkvpp.ilkdvi.dliekhAve.elvvlleggdrpekeilklsvGkvlkei

WQEVMESLTGESL-RKFLLYSGHDGTIQPFLSAFNVTDFKWPPYASFLMLEILEVtgtpqaSTPQYAVRMLYNGELLKFPFCDANPCPMDQFEAYVNTII
 ... .   .|.  ||. ||| || |. . | |..| | ||||.|. ..||. |          .| ||.||... |... .. . .|...|.| .....
lenlekakekeiparklrLysaHDttlmtLLlalgvFDdkWPpfaadvileLyed......kageyfvrvlYqekelrlrgseedlvPlekFkallavlv

-PHNPAEDCKVSD
 |.. |..||..|
lpkdyaaeCkled
subfamily_PXYLP1_pd Subfamily PXYLP1 26-415 4.4e-34 109.4 In-house 3-380 (419) alignment 
Range on Protein: 26-415
Range on HMM: 3-380/419.0
YCGKPTEAKT---LGLPEGFKLKQTHVIIRHGDRVRAaYHGPCWDgdKAIWDCTLTSASLPAIKHDSHYI--------VVDRIYRRGYLNGRES---DAG
||  |  ...    ...||||||  .|.||||||    .. |  .  .| ..|.|..|| .  ..   ..          |   . | |..        .
ycnipdveirseeGkikegfkLkavlvvirhGDrtPl.sdipksk..raeinCdlsaasknlvdklksfldnssseasgsdfenkvgplkslPllpnher

DCAIGHLTLEGYKQQELNGQILRKVYVDT-GFL--KSNFSSTEMYLRSDDESRTMQSAQALILGMYPPATIAsdRAQVADINTMDKLFDSiepntMLCPK
 | .|.||  |  |   .|..|||||  . ..|  . ..|| |..| .  ..||.||| ||. |..| |..   . .| . ...   ...       || 
iCelgqLtqkGvvqhLevGdllrkvYakklklLlkpnelssDevvlettrkrrtlqsalallygllpkaklk..airvrespsvafClge.....CsCPa

LSEYnhgFlKTDMWRHHYngITKPlllevqKALGSNKTLGsggcsHTLYLPIAVTRKLDIDGLddlVDCIHTHQCHGFAIPPG-------ITDDLFKRMV
| .      .  . .. .  . .       | |   |..|     .||.  |  |... |      || . |. ||  ..| .       .  | .... 
llrk...r.lekeadkql..Llrg......kvldvmksvg.....etlkgtilqttlngisnp...vdalltvlChnvslPcrreGcvepshvdvlhkla

DELLYRWNSMYLYpsrEKYATVGIGFLIKDIWQEVMESLTGESLRKFLLYSGHDGTIQPFLSAFNVTDFKWPPYASFLMLEILEvtgtpQASTPQYAVRM
|||  | .    |   ..   ...  |..|| . ..    | .  || |||||| |..| ..|... . ... ||| |. |. .     .... .| .|.
delsqrsakksyy...klsGllraypllrdivsrmlkiieGvdkekfvlysghDvtlrplvaaLglseartiayasrlvfelyr.....reaskeyylrv

LYNGEL--LKFPFCDA
||||     |  ||. 
lynGkDvtqkvdfCeg
His_Phos_2 Histidine phosphatase superfamily (branch 2) 43-404 1.2e-28 93.0 Pfam-A 1-347 (347) alignment 
Range on Protein: 43-404
Range on HMM: 1-347/347.0
KLKQTHVIIRHGDRVRAAYHGPCWDGDKAIWDC--------------TLTSaslpaikhdshyivvdriyrrgylngrESDAGDCAIGHLTLEGYKQQEL
.||. .|.||||||      .      | |  .              | ..                           |.   ..  |.|| .| ||.| 
eLkgvvvviRHGdRtPkqkfkksvtsekfisllklknvlekkghfpgtkrk...........................eklqlilkwgglThsGrkqaee

NGQILRKVYVdtGFLKSNFSSTEMYLRSDDESRTMQSAQALILGMYPPATI-------ASDRAQVADINTMDK----LFDSIEPNTMLCPKLSE--YNHG
 |. ||. |.  |.|.... . ... ||..| |. .||||.. |...|               . | ..|||.    | . . ...  ||.. .  ..  
lGeqlrqrYp..gllrdhltyedvkirssserRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellregaescpafawppikve

FLKTDMWRHHYNGITKPLLLEVQKALGSN-KTLGSGGCSHTLYLPIAVTrKLDIDGLDDLVDC-----IHTHQchgfaippgitddlfkrmvdelL----
  ...  . . . ....|  .... .... . |     .      .    | ||  . .|.|.     .|  |                      |    
krvvelvnklkkvmdenlakrlsalctgednllfkerweklfreffeee.kfdiskipelydtmkydalhnrq......................ledle

--YRWnsmylYPSREKYATVGIGFLIKDIWQEVMESLTGES---LRKFLLYSGHDGTIQPFLSAFNVTD------FKWPPYASFLMLEILEVtgtpqaST
  |.      |   .. . .  . |.... ... ..| ..     .|..||..|| .| ..|.|... .       ...|||| ...|..|       |.
elykl.....ygigdeeklkigllllnpllkkilsdleetqpsrhaklrlyfthDshiytllnaLgleekiareaspelpyasqivfelyed......se

PQYAVRMLYN
 .. ||.|..
kkfyvrllfs
His_Phos_2 Histidine phosphatase superfamily (branch 2) 43-404 1.2e-28 93.0 In-house 1-347 (347) alignment 
Range on Protein: 43-404
Range on HMM: 1-347/347.0
KLKQTHVIIRHGDRVRAAYHGPCWDGDKAIWDC--------------TLTSaslpaikhdshyivvdriyrrgylngrESDAGDCAIGHLTLEGYKQQEL
.||. .|.||||||      .      | |  .              | ..                           |.   ..  |.|| .| ||.| 
eLkgvvvviRHGdRtPkqkfkksvtsekfisllklknvlekkghfpgtkrk...........................eklqlilkwgglThsGrkqaee

NGQILRKVYVdtGFLKSNFSSTEMYLRSDDESRTMQSAQALILGMYPPATI-------ASDRAQVADINTMDK----LFDSIEPNTMLCPKLSE--YNHG
 |. ||. |.  |.|.... . ... ||..| |. .||||.. |...|               . | ..|||.    | . . ...  ||.. .  ..  
lGeqlrqrYp..gllrdhltyedvkirssserRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellregaescpafawppikve

FLKTDMWRHHYNGITKPLLLEVQKALGSN-KTLGSGGCSHTLYLPIAVTrKLDIDGLDDLVDC-----IHTHQchgfaippgitddlfkrmvdelL----
  ...  . . . ....|  .... .... . |     .      .    | ||  . .|.|.     .|  |                      |    
krvvelvnklkkvmdenlakrlsalctgednllfkerweklfreffeee.kfdiskipelydtmkydalhnrq......................ledle

--YRWnsmylYPSREKYATVGIGFLIKDIWQEVMESLTGES---LRKFLLYSGHDGTIQPFLSAFNVTD------FKWPPYASFLMLEILEVtgtpqaST
  |.      |   .. . .  . |.... ... ..| ..     .|..||..|| .| ..|.|... .       ...|||| ...|..|       |.
elykl.....ygigdeeklkigllllnpllkkilsdleetqpsrhaklrlyfthDshiytllnaLgleekiareaspelpyasqivfelyed......se

PQYAVRMLYN
 .. ||.|..
kkfyvrllfs
subfamily_MINPP1_pd Subfamily MINPP1 33-195 1.6e-06 19.2 In-house 20-167 (420) alignment 
Range on Protein: 33-195
Range on HMM: 20-167/420.0
AKTLGLPEGFKLKQTHVIIRHGDRVRAAYHGPC-WDGDKAIWDCTLTSASLPAIKH-DSHyivvdriyrrgylngRESDAGDCAIGHLTLEGYKQQELNG
 ..  ..|| ||.. ..|.||| |.  . .     .  ..| . .   .   .|.  | .                ..   .   ..|. .|... | ..
dikkeaeegCklvklqiiaRHGtRypskskikkiqetlekiknyseqldgklsilnedle...............snleyetelekslvaqgqeeleela

QILRKVYVDTgFLkSNFSSTEMYLRSDDESRTMQSAQALILGMYPPATIASDRAQVADINTMDKL
. | . . .  |   . . ......| ...||..|||| . |. . .... |. .   ... .. 
krlarrfpal.fe.evynpdsfsfastakkRtvksaqaFaeGLsetgevlgdefnivlqeiseqe