Gene ACP5-3 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PAP
Subfamily ACP5
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP149_AA protein Get Run
SpurP149_AA_37-256 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PAPL_pd Subfamily PAPL 39-255 7.9e-106 344.0 In-house 1-212 (212) alignment 
Range on Protein: 39-255
Range on HMM: 1-212/212.0
LVLADWGGIPIWPYFSPFQWAVANQMTNTASDHIAKFVLALGDNFYEKGVTDVDDPRFKQTYEDVFHWPSMQVPWYVVGGNHDHYGNISAQVAYTKVSQR
|||.||||.. .||... |.|||......|... |.||||||||||||||.||||.|||.|.||||...|.||||||| ||||..||.|||.||.|.|.|
lvlgDwGgleeapyttaaqeavakelgkvaeeleaqfvlalGDnfYekGvkdvddarfketfedvftaeslqvpwyvvagnHDykGnvsaqiaYsklskr

WKFPDYYHSHSFQIPDFNRTLAIILVDTVILCGITDDETtgsnLPGPASISAAEEQWKWLEEQLEAfKSADYLVVGGHYPVWSVAEHGPTKILVDRLLPF
||||..|...||.||| |.|....|.|||.|||..||..    | ||...|.|||||.||||.|.| ..||||.|.||||||||||||||||||.|| |.
Wkfpslyytksfkipdsnatvqlvlidtvllcgksddlk....legpvdvslaeeqwawleeeLka.seadylivaGhypvwsvaehGptkiLvkrLkPl

LEKYNVTAYFCGHDHNL
|||||||||..||||||
LekynvtaylsGhDhnl
ACP5 38-254 2.3e-67 218.5 In-house 1-198 (198) alignment 
Range on Protein: 38-254
Range on HMM: 1-198/198.0
FLVLADWGGIPIWPyfspfQWAVANQMTNTASDHIAKFVLALGDNFYEKGVTDVDDPRFKQTYEDVFHWPSMQVPWYVVGGNHDHYGNISAQVAYTKVSQ
|||..|||. .  .     | |||.||...|... ..|||.||||||..|||.|||||||...|.... .|.||||||| ||||..||.|||..|.| |.
flvvGDwGrkgeyn.....qsavakqmgkvaekldidfvlslGDnfyddGvtsvddprfkesfekiytakslqvpWyvvlGNHDyrgnvsaqieyakrsk

RWKFPDYYHSHSFQIpdfnrtlaiilvdTVILCGITDDETTGSNLPGPASISAAEEQWKWLEEQLEAfKSADYLVVGGHYPVWSVAEHGPTKILVDRLLP
...|| ...|.|...             .|. .  .... . ..  .... ..||||.||||..|.. ..||...| ||.||.|..|||.|| ||.||||
dsrfpslryslskke.............vvtelftekkdeksdqrevaerekyaeeqlkwlekalak.stadwkiVvGHhpvySigehgdtkelverllp

FLEKYNVTAYFCGHDHN
.|.||.|.||..||||.
llkkykvdaYlnGHdHc
Metallophos Calcineurin-like phosphoesterase 37-254 1.2e-21 70.9 Pfam-A 2-199 (200) alignment 
Range on Protein: 37-254
Range on HMM: 2-199/200.0
TFLVLADWGGIPIWPYfspfqWaVANQMTNTASDHIAKFVLALGDNFYEKGVTDVDDPRFKqtyeDVFHWPSMQVPWYVVGGNHDHYGNISAQVAYTKVS
..||..|..| . ...     . ..... . |... . .|| |||...     .    ..           .. .|.... |||. ..  ||  .. ...
rilvigDlHgglddle.....d.lllillkiaaeekpdlvlflGDlvdrgdwssetlalld....ylvlklllpipvfllrGNHesdpgnsaygflleql

QRWKFPDYYHSHSFQIpdfnrtlaiilvDtvILCGITDDETTGSNLPGPASISAAEEQWKWLEEQLEAFKSADYLVVGGHYPVWSVAEHGPT----KILV
 ..  ....  . .              .  |  . | .|..|.. ..|     |.|.. . ...|.... .|. .. .| |..|  ..| .        
kdlrglangeeeyenl............k..itllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddigselfgp

DRLLPFLEKYNVTAYFCGHDHN
| | ..||||.|.....||.| 
dalekllekygvdlvlrGHtHk
subfamily_ACP5_pd Subfamily ACP5 62-254 3.6e-14 45.1 In-house 14-187 (189) alignment 
Range on Protein: 62-254
Range on HMM: 14-187/189.0
NQMTNTASDHIAKFVLALGDNFYEKGVtdvDDPRFKQTYEDVFHWPSMQVPWYVVGGNHDHYGnisaqvAYTKVSQRWKFPdyyHSHSFQIPDFNRtLAI
..  ...... ..... .||  |...    .. .   .. ...   . .||. |. |||..         ......|.. |   .....   |..    .
atllkeeeaneldliihvGDlaYalka...kneavwdefmnlieplaskvPymvsiGnhesds......nfsaykkrfsmp...sknewYsfdygp.vhf

ILVDTVILCGITddettgsnlpgpasisaaEEQWKWLEEQLEAF---KSADYLVVGGHYPVWSVAEHGPT----KI-----LVDRLLPFLEKYNVTAYFC
| ..| .                       .||.||||..|...   |. ....| || |..   ...      .      |...| . |.||.|  ...
islstevdfslg..................seqykWLekdLkeannrkktpwiivmgHrPmYcsnkdeddctkeetlvrkglresledllykykvdlals

GHDHN
||.|.
gHeHs
Metallophos_2 Calcineurin-like phosphoesterase superfamily domain 68-265 1.3e-08 27.0 Pfam-A 23-131 (156) alignment 
Range on Protein: 68-265
Range on HMM: 23-131/156.0
ASDhiAKFVLALGDnF-YEkgvtdvddprfKQTYEDVfhwpsMQVPWYVVGGNHDhygnisA-----QVAYTKvsqrwkfpdyyhshsfqipdfnrtlai
. .  ....| .|| .  .           ....|..     ...| ..| ||||      .     ..| ..                           
ike..vdlilhaGD.lvep...........eevvell.....edipvlavrGnhD......eaelpkelavel...........................

ilvdtvilcgitddettgsnlpgpasisaaeeqwkWLEEQLEAFKSADYLVVGGHYPVwsVAeHGPTKilvdrLLPFLEKYNVTAYFCGHDHNLQHIKQD
                                    |... . ..  . |.| |.     |  ... .     |   |..... ..|.|| |. .  |..
...................................llaaaaleiegdrvllvhgtpls..vq.sseee.....laellkeagadlvflGHtHkpkvekrg

NSTV
. .|
gtlv
PAPL 187-254 1.4e-08 27.1 In-house 120-193 (194) alignment 
Range on Protein: 187-254
Range on HMM: 120-193/194.0
SISAAEEQWKWLEEQLEA--FKSADYLVVGGHYPVWSVAEHG----PTKILVDRLLPFLEKYNVTAYFCGHDHN
...  .||..||||.|..   .  ....| || |...  ..      ..  .. | . | ||.|  ...|| |.
dvkekseqyewleedlakvnRsktPWiivmgHrpmYcsnkdkddckekakmlaaledllykygVDlvlaGHeHs
Abhydrolase_1 alpha/beta hydrolase fold 36-154 1.1e-06 15.7 Pfam-A 107-222 (230) alignment 
Range on Protein: 36-154
Range on HMM: 107-222/230.0
YTFLVLADWGGIP--IWPYFSPFQWAVANQMTntASDHIA--KFVLALGDNFYEKGVTDVDDPRFKQTYedvfhwpsMQVPWYVVGGNHDHYGNISAQVA
 .  . ...|  .  .. ...|.  .  ...   |.. ..  . .   |.... .|   |.|    ...        ..||..|..| .|.. . .|...
lskgikplqgdasvqaqsllrpqvtdflkrfd..ansyaregetraldgkllaalgrdlvwdvtetlkt........ilvptlvisgtdDplvpykasek

---YTKVSQRWKFPDYYHSHSFQIPD
    .  ||. ......|   .. ||
laelipksqlvvidgpgHlafldkpd
PAPL 60-151 1.4e-06 20.5 In-house 13-101 (194) alignment 
Range on Protein: 60-151
Range on HMM: 13-101/194.0
VANQMTNTASDHIAKFVLALGDNFYEKGVTDVDDPRF-KQTYEDVfhwpSMQVPWYVVGGNHDHYGNISAQVAYTKVSQRWKFPDYYHSHSFQ
 ...........  ...| .||  |. .  .  |     .  | .    . .||. |. |||..  | |...|... ..... . ...... .
slkrlqketqkgkydailhvGDlaYaddeqnewdgdefmrqiepl....aasvpymvapGNHEeeynfsnykarfsmpgseegesnssesgsn