Gene ACP2-2 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP2
Subfamily ACP2
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP173_AA protein Get Run
SpurP173_AA_14-404 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_ACP2_pd Subfamily ACP2 31-376 8.4e-122 399.2 In-house 8-359 (361) alignment 
Range on Protein: 31-376
Range on HMM: 8-359/361.0
QLSDVGLLYRHGDRSPAQTFPTDPYREDSWPQGWGQLSKLGMQMQYGLGQFLGKRY-QDTGFLNANYTRTEINIRSTDVDRCLMSAQSDLSGLYQPLPEM
.|  | .|.||||||| .|.|.|.|.||.||||.|||...|||.|| ||.|| ||| .||.||.|.|....|..||.||.|.|||||| |.||..| ...
kLkfvqvlfRHGdRsPlntypndkykedewpqglGqLTeeGmqqqyeLGkfLrkrYvedtkfldakynpkqiyvrSsdvnRTlmSaqsvlaglfppetgv

QFNPNISWQPIPVHTKPKENDYLLRtDGTSCPYYDELYAKELATARVKQINEENKDFFQKLKKDTGvtEDITVNTVYTIEDPLFCEQA-HN-RTLPTWAS
.......|||.||||...|.|.||| . ..|| |||| ..  ... ||...||||....||.. ||  |||. ...|.. | |.||.. .| ..||.||.
dypdeqeWqpvPvhtvseeedlllr.akknCprydellqeakespevkklleenkelleklsestg..edidlenfyqlsdtlicerkyanelnlpewan

NDVMLKLENLTNIGMAMLFG-----TKELARLKGGPLVGKMISDMEKKSK-NVTGTPIKFFMYSAHDTTLAAFMSALGVYNGKQSPYASAVGVELWEDdA
.... |||.|..  ... ||     |.||..|.||||. .....|..|.| . . .  |.|.||||||||||...|||....|. |||||. |||.|.  
delfekleeladkvkeaefglnnektrelkklrgGpllnellenmkeklkceekkkklklflYSaHDttlaalLeaLgifekkappyasaiivElyee.d

TKSFNVSIWFRNSTTQEVPyKLHLMDC--SDMCGLERFKELVLDVIPGNVEAECGAT
.....|....||.|... | .|.| .|  ...| |..||..| ..|| .|. .| |.
dgkplvkvlyrnetskdpp.eltlpgCkgeedCplskfkkivkpfipddvdelCeak
0053031 Phosphoglycerate mutase-like 35-373 8.4e-90 294.4 In-house 6-340 (342) alignment 
Range on Protein: 35-373
Range on HMM: 6-340/342.0
VGLLYRHGDRSPAQTFPTDPYREDSWPQGWGQLSKLGMQMQYGLGQFLGKRYqdTGFLNANYTRTEINIRSTDVDRCLMSAQSDLSGLYQPLPEMQFNPN
| .|.|||.|.| ...| ||. |  .| |.|.|. ||....| ||..| |||  .|.|. .|...|. .||.||||.|.|||. | ||..| .   .||.
vivlvRHGaRtPlskgpldplnewfypcgageLTplGreqayelGrrlrkrY..lgllpstynpdevyvrssdvdRtlqSAqaflaGlfppegtpilnpl

ISWQPIPVHTKPKENDYLLRTDGTSCPYYDELYAKELATARVKQINEENKDFFQKLKKDTGVTEDITVNTVYTIEDPLFCEQAHNRTLPTWASNDVMLKL
..|||||.|| |. .|.||... ..||..|.|... ||.. ||...|. ....||| |..|.| .  ...|... | |..|.||...|| | . . . .|
lgwqpipihtepessdalllpnydpcpafdkllkealaseevkellerylellqklskglgltlsdlldlvsdlydlllyelahglplppwctlftleel

ENLTNIGMAMLF---GTKELARLKGGPLVGKMISDMEKKSKNvtGTPIKFFMYSAHDTTLAAFMSALGVYNGKQSPYASAVGVELWEDDatKSFNVSIWF
..|... . ...    . |||.| ||||........|.| ..  ....|...|.|||||.||..||||.....  |||| . .||.||.  ... | . .
kalyaldllyyyglgpgnelaklaggpllneilarleekisg..pldlklylyfahdttiaallsaLglfddqlPpyasnlvfElyedp..geyyVrvly

RNSTTQeVPYKLHLMDCSDMCGLERFKELVLDVIPGNVEAEC
.. |..  |. |.|  |...| |..||||| ...||. | .|
nggtls.eplvlplpgcdglcplsefkelvkkllpgdfeklC
0049226 Phosphoglycerate mutase-like 35-373 1.3e-89 293.6 In-house 6-340 (342) alignment 
Range on Protein: 35-373
Range on HMM: 6-340/342.0
VGLLYRHGDRSPAQTFPTDPYREDSWPQGWGQLSKLGMQMQYGLGQFLGKRYqdTGFLNANYTRTEINIRSTDVDRCLMSAQSDLSGLYQPLPEMQFNPN
| .|.|||||.| ...| |...|  |. |.|.|. ||....| ||..| |||  .|.|. .|...|. .||.||||.|.|||. | ||..|     ..|.
vqvliRHGdRtPlakgpldflnewfwgcglgeLTplGreqayelGrrlrkrY..lgllpstynpdevyvrssdvdRtlqSaqaflaGlfppeltpilvpl

ISWQPIPVHTKPKENDYLLRTDGTSCPYYDELYAKELATARVKQINEENKDFFQKLKKDTGVTEDITVNTVYTIEDPLFCEQAHNRTLPTWASNDVMLKL
..|||||..| |. ||.||... .|||..|.|. . |... |....|| .|...||.| .|..    .....|. | | .|.||. .|| | | . . .|
ldwqpipiitepesndtllllpydscpnfdkllkellkseevqlfleeildllkklskllglnlstlsdvadtlydlllyelahglplppwcslftleel

ENLTNIGMA---MLFGTKELARLKGGPLVGKMISDMEKKSKnvTGTPIKFFMYSAHDTTLAAFMSALGVYNGKQSPYASAVGVELWEDDatKSFNVSIWF
..| .. .    ... . |.||| ||||........|.. .  .... |...|.|||||.||..||||...... ||||.. .||.|.|  ... | . .
kalyaldllyyygigygeeiarlaggpllneilarleeaie..gpsdlklylyfahdttiaallsalglfddqlPpyasnlvfElyecd..geyyVrvly

RNSTTQEvPYKLHLMDCSDMCGLERFKELVLDVIPGNVEAEC
.. .... |. |.|..|...| |..||||| ...||. | .|
nggvlsl.pvtlplpgcdglcpldefkelvkkflpgdfeelC
0046349 Phosphoglycerate mutase-like 35-375 4.3e-86 282.5 In-house 10-392 (409) alignment 
Range on Protein: 35-375
Range on HMM: 10-392/409.0
VGLLYRHGDRSP---AQTFPTDPYREDS-WPQGWGQLSKLGMQMQYGLGQFLGKRYQDTGFLNAN--YTRTEINIRSTDVDRCLMSAQSDLSGLYQPLPE
| .|.|||.|.|     ..| .|.     .| |.|||. ||....| ||..| ||| |.|.|. |  |...|| .||.||||.|.|||. | ||..||  
vqvlfRHGaRtPtkklsflpnwpginwtngpcgagqLTplGreqayelGkrlrkrYvdlgLlpsnslynpdeiyvrssdvdRtlqSAqaflaGlfpplgg

------MQFNPNISWQPIPVHTKPKEN----DYLLRTDGTSCPYYDELYAKELAT-ARVKQ-----------INEENKDFFQKLKKDT-----GVteDIT
      .| .... .||||..| | ..    |. | . ...|| .|.|... |.. . |..           ...|.||...|| . .     |.  ..|
eivpllrqdlldppfqpipidtvpiseddalddtllppdslcpaldkllkenlkslsevleflvdealldlelldetkdllkklaerlnselpgl..nlt

-VNTVYT-IEDPLFCEQAHNRTLPTW---ASNDVMLKLENLTNIGMAMLFGTKELARLKGGPLVGKMISDMEKKSKNvtGT------PIKFFMYSAHDTT
 .  |.  . | |..|.||...|| |    . . . .|..|... .  |.|..|||.|.||||........|.. ..  ..      . |...|.|||||
dpldvasllydtllyetahglplppwcdlftpeelkvlayladleyyylygsgelaklaggpllneilarledaisg..knpvtfpldlklylyfaHdtt

LAAFMSALGVYN-----GKQSPYASAVGVELWEDDATKSFNVSIWFRNSttqevPYKLhlMDCSDMCGLERFKELVLDVIPG----NVEAECGA
.||..||||...      .  |||| . .||.|.. .. . | . ...      |..|  ..|...| |..||||. ...||    ... .|. 
iaallsaLglfdrlfrssdippyasnlvfElyecpsdgeyyVrvlyngg.....plpl..pgcgegcplsefkellkkrlpgcgltdfdklCpl
0048946 Phosphoglycerate mutase-like 15-404 2.4e-83 273.4 In-house 27-440 (447) alignment 
Range on Protein: 15-404
Range on HMM: 27-440/447.0
LNCVMQARPPRAfplFQLSDVGLLYRHGDRSPAQTF-----------------------------PTDPYREDSWPQGWGQLSKLGMQMQYGLGQFLGKR
 .  ... .|     ..|  | .|.|||.|.| ...                             ..... |  || |.|||. ||....| ||..| ||
pgygipepvpeg...celkqvqvlfRHGaRtPtkkylkgleplldllknanvlelggdlsflndwkyqlkneplwpcglgqLTplGreqlyelGkrlrkr

YqdTGFLNanyTRTEINIRSTDVDRCLMSAQSDLSGLYQPLpemqfnPNISWQPIPVHTKPKENDYLLRTdgtSCPYYDELYAKELAtarvKQINEENKD
|  .|.|.   ...|| .||.||||.|.|||. | ||..|       |....||||.|| |. ||.||..   ||| ..||. ||||    . ..| .|.
Y..lgllp...npseiyvrssdvdRtlqSaqaflaGlfppe......pplgyqpipihtvpssndnlllp...sCpafkellkkela....eelkellke

FFQKLKKDTGvTEDITVNTVYTIEDPLFCEQA-HNRT-LPTWASNDVMLKLENLTNIGMAMLFG-TKELARLKGGPLVGKMISDMEKKSKNVTgtpiKFF
....||| .| . ..|.. ||.. | |..| | |... |. . . . ...||.| .. . ...| . ||||| ||||........|.. .. .    |..
llerlkkllg.glnltlsdvydlydlllyetaihglsplcslftpeelevleyladlefyyeygygdelarlaggpllneilarledaisgds....kly

MYSAHDTTLAAFMSALGVYNGKQS------------------PYASAVGVELWEDDA----TKSFNVSIWFrnsttQEVPYKLHLMDCSD--MCGLERFK
.|.|||||.||..||||... ..                   |||| . .||.|...    .... | . .     .. |..|.... ..  .| |..||
lyfaHdttiaallsaLglfddelplpadnlpfnrlfrsseivPyasnlvfElyecpsslpsdgeyyVrvly.....ngeplplpgCgsgpgglCplddFk

ELVLDVIPgNVEAECGATFMKNYTIPILIGTSLIALILVLIFVYLV
||. ...| . | .||.|    ... .||.. |. |.|.|....|.
ellkkflp.dweklCgltlsvlallsvlidvllltlllllllllll
0049059 Phosphoglycerate mutase-like 28-374 4.8e-83 272.4 In-house 39-435 (435) alignment 
Range on Protein: 28-374
Range on HMM: 39-435/435.0
PLFQLSDVGLLYRHGDRSPAQ-----------------TFPTDPYREDSW---PQGWGQLSKLGMQMQYGLGQFLGKRYqdtGFLnanYTRTEINIRSTD
. ..|  | .|.|||.|.| .                 |.|..|. .  .   |.|.|.|. ||....| ||..| |||   |||   |...|. .||.|
egcelkqvqvlfRHGaRtPtsklikklealwekllslltypngplsflndwnyplgageLTplGreqayelGkrlrkrY...gfL...ynpdevyvrssd

VDRCLMSAQSDLSGLYQPL--PEMQFNPNISWQPIPVHTKPKENDYLlrtDGTSCPYYDELYAKELATARVKQI-NEENKDFFQKLKKDTGVTeDITVNT
|||.|.|||. | ||..|   ..  .||.. .||.|..|..  ||.|   .  ||| .|||. . ||.. .... .|......|.| . .|.|   .|..
vdRtlqSaqaflaGlfppeilgsqllnplnvyqpvpietvdsdndtl...pydscpafdellkellasdeflelflerilkllqellpglglt.psdvld

VYTI--EDPLFCEQAHNRTLP--TWASNDVMLKLENLTNIGMAMLFG-TKELARLKGGPLVGKMISDMEKKSKNVTGT--------------PIKFFMYS
.| .   | |....||...||   . . . . .||.| .. . .|.| . |.|.| ||||........|.. .. . .              . |...|.
lydlckydtlllgyahglplpfcslfteeelevleyladlefyylygygdeiaklaggpllneilarledaingdstnlnltldsnpatfpldlklylyf

AHDTTLAAFMSALGVYNGKQS---------------------PYASAVGVELWEDDATKSFNVSIWFRNsttqeVPYKLHLMDCSD--MCGLERFKELVL
|||||.|...||||......                      |||| . .||.|.. .... | . . .     ....|.... ..  .| |. ||||| 
aHdttiapllsaLglfddqlplpadntpfpeldrlfrtseivPyasnlvfElyecpdgneyyVrvlyng.....kvlplpgcgsgpgglCplddFkelvk

DVIPGNVEAECG
...||.   |||
kflpgddfdeCg
0047369 Phosphoglycerate mutase-like 30-374 2.7e-79 260.3 In-house 42-437 (438) alignment 
Range on Protein: 30-374
Range on HMM: 42-437/438.0
FQLSDVGLLYRHGDRSP-----------------AQTFPTDPYREDS---WPQGWGQLSKLGMQMQYGLGQFLGKRYqdtGFLnanyTRTEI-NIRSTDV
..|  | .|.|||.|.|                 | |.|..|.       .|.|.|||. ||....| ||..| |||   |.|    .. ..  .||.||
celkqvqvlfRHGaRtPtksklkkleplwellenattypsgplsflndwlgpcgagqLTplGreqayelGkrlrkrY...glL....npedvlyvrssdv

DRCLMSAQSDLSGLYQPLPEMQFNPnISWQPIPVHTKPKENDYLLRT-DGTSCPYYDELYAKELATARVKQINeeNKDFFQKLKKDTGVtEDITVNTVYT
||.|.|||. | ||..|  .  ..| | |||||.|| |...|.||.. .  |||..|||. . ||.. ....   .||. ..||| ..   ..|...|..
dRtlqSAqaflaGlfppegtgelap.ilwqpipihtipesddfllnllpsdscpafdellkeflasdeflell..lkdilkrlkkllpg.lnltpsdvld

IEDPLFCEQAHNRT----LP---TWASNDVMLKLENLTNIGMAMLFG-TKELARLKGGPLVGKMISDMEKKSKNVTGT--------------PIKFFMYS
. | .... ..|..    |.    . . . . .||.| .. . .|.| ..|||.| ||||........|.. .. . .              . |...|.
lydlcaydtlangyaglplspfcslftpeelevleyladlefyylygygnelaklaggpllneilarledaingkstnlnltldsngvtfPldlklylyf

AHDTTLAAFMSALGVYNGKQS---------------------PYASAVGVELWEDDATKSFNVSIWFrnsttQEVPYKLHLMDCSD--MCGLERFKELVL
|||||.||..||||... ..                      |||| . .||.|.. .... | . .     ......|. .. ..  .| |..||||| 
aHdttiaallsaLglfddtwplpglpldkialnrlfrsseivPyasnlvfElyecpsdgeyyVrvly.....ngkvlplpgcgsgpgglCplddFkelvk

DVIPGNVEAECG
...||. | .||
kllpgdfeelCg
0048439 Phosphoglycerate mutase-like 35-365 5.9e-78 255.8 In-house 12-390 (391) alignment 
Range on Protein: 35-365
Range on HMM: 12-390/391.0
VGLLYRHGDRSPAQTFPT--DPYREDSW---PQGWGQLSKLGMQMQYGLGQFLGKRYQDTGFLNANY--TRTEINIRSTDVDRCLMSAQSDLSGLYQPLP
| .|.|||.|.| ...|   ||. .  .   | |.|.|. ||....| ||..| ||| |.|.|. .|  ...|. .||.||||.|.|||. | ||..|| 
vqvlfRHGaRtPtssypnkldpllnkllpngpcglgeLTplGreqlyelGrrlrkrYvdlgllpskytlnpsevyvrssdvdRtlqSAqaflaGlfpplg

EMQFNP------NISWQPIPVHTKPKENDYLLRTDGTSCPYY------DELYAKELATARVKQINEENKDFFQKLKKDTGVTED-----ITVNTVYTIED
    ..      .. ..|.|..| |. .|.|| .  ...|..      ..|..    .  .....|.....|. ..| | ..        ..  ..|..|
ltvilvivvesedpllnplpintcplledlllldalsalprfylseilerlaevlnrvlglnltaedvlslfdlcaketaalgsllklssplcdlftlyd

PLFCEQAHNRTLPTWASNDV-----MLKLENLTNIGMAMLFGTKELARLKGGPLVGKMISDMeKKSKNvtgTPIKFFMYSAHDTTLAAFMSALGVYNG--
 |..|.||...|| |. ...     . .| .|.|  .. |.|..|.|.| ||||......|. . . .   .. |...|.|||||.||..||||..|   
tllyeyahglplpewltdellspellkqladlvnelyyyltgsgeiaklaggpllneilddl.vangp...sdpklylyfaHdttiaallsaLglfndtl

----KQSPYASAVGVELWEDDATKSFNVSIWFRNSTTQEvPY--------------KLHLMDCSD----MCGLERFKELVLDVI
    .. |||| . .||.|.. .... | . ... |..  |.               |.|  |..    .| |..|.||| ..|
plpadlppyasnlvfElyecpsdgeyyVrvlynggtldl.prdltlldldefllrlvlplpgcgsgpgglCplddFvelvkkri
His_Phos_2 Histidine phosphatase superfamily (branch 2) 33-330 9.1e-50 162.5 Pfam-A 3-345 (347) alignment 
Range on Protein: 33-330
Range on HMM: 3-345/347.0
SDVGLLYRHGDRSPAQTFPTDPYRED--------------------------SWPQGWGQLSKLGMQMQYGLGQFLGKRYQdtGFLNANYTRTEINIRST
  | .. |||||.| |.|...   |                            .. .||.| . |..... ||..| .||.  |.|. ..|. .. |||.
kgvvvviRHGdRtPkqkfkksvtsekfisllklknvlekkghfpgtkrkeklqlilkwgglThsGrkqaeelGeqlrqrYp..gllrdhltyedvkirss

DVDRCLMSAQSDLSGLYQPLPE---MQFNPNISWQPIPVHTKPK---ENDYLLRTDGTSCPYYDE--LYAKELATARVKQINEENKDFFQ-KLKKDTGVT
. .|.|.|||. . ||..|  |    . ..  ........| ..   ... |||..  ||| ...  .  .. ... |.. ... .. .. .|..  .  
serRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellregaescpafawppikvekrvvelvnklkkvmdenlakrlsalctge

EDITVNTVYTIEDPLFCEQA--HNRTLPTWASN--DVMLKLENLTNIGMAMLF--GTKELARLKGGPLVGKMISDMEKKSKNVT-GTPIKFFMYSAHDTT
. ..   ...  .  |.|.   .. ..| ....  . .|... |..   .. .   ..|...  |..|. .... .... .. .     |...|..||..
dnllfkerweklfreffeeekfdiskipelydtmkydalhnrqledleelyklygigdeeklkigllllnpllkkilsdleetqpsrhaklrlyfthDsh

LAAFMSALGVYN------GKQSPYASAVGVELWEDDATKsFNVSIW
......|||...       .. ||||.. .||.||. .| | |.. 
iytllnaLgleekiareaspelpyasqivfelyedsekk.fyvrll
His_Phos_2 Histidine phosphatase superfamily (branch 2) 33-330 9.1e-50 162.5 In-house 3-345 (347) alignment 
Range on Protein: 33-330
Range on HMM: 3-345/347.0
SDVGLLYRHGDRSPAQTFPTDPYRED--------------------------SWPQGWGQLSKLGMQMQYGLGQFLGKRYQdtGFLNANYTRTEINIRST
  | .. |||||.| |.|...   |                            .. .||.| . |..... ||..| .||.  |.|. ..|. .. |||.
kgvvvviRHGdRtPkqkfkksvtsekfisllklknvlekkghfpgtkrkeklqlilkwgglThsGrkqaeelGeqlrqrYp..gllrdhltyedvkirss

DVDRCLMSAQSDLSGLYQPLPE---MQFNPNISWQPIPVHTKPK---ENDYLLRTDGTSCPYYDE--LYAKELATARVKQINEENKDFFQ-KLKKDTGVT
. .|.|.|||. . ||..|  |    . ..  ........| ..   ... |||..  ||| ...  .  .. ... |.. ... .. .. .|..  .  
serRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellregaescpafawppikvekrvvelvnklkkvmdenlakrlsalctge

EDITVNTVYTIEDPLFCEQA--HNRTLPTWASN--DVMLKLENLTNIGMAMLF--GTKELARLKGGPLVGKMISDMEKKSKNVT-GTPIKFFMYSAHDTT
. ..   ...  .  |.|.   .. ..| ....  . .|... |..   .. .   ..|...  |..|. .... .... .. .     |...|..||..
dnllfkerweklfreffeeekfdiskipelydtmkydalhnrqledleelyklygigdeeklkigllllnpllkkilsdleetqpsrhaklrlyfthDsh

LAAFMSALGVYN------GKQSPYASAVGVELWEDDATKsFNVSIW
......|||...       .. ||||.. .||.||. .| | |.. 
iytllnaLgleekiareaspelpyasqivfelyedsekk.fyvrll
subfamily_ACP6_pd Subfamily ACP6 65-374 4.8e-39 126.1 In-house 76-372 (376) alignment 
Range on Protein: 65-374
Range on HMM: 76-372/376.0
GQLSKLGMQMQYGLGQFLGKRY-QDTGFLNANYTRTEINIRSTDVDRCLMSAQSDLSGLYQPLPEMqfnpniSWQPIPVHTKPKENDYLLRtDGTSCPYY
||| | |||  . ||. | ||| .| .||  ...  |. ||||...| | ||.  ..|||.              || ..|. .... |.  .  .||  
GqLtkvGmqqvfdLGrkLrkrYvedikfLsqefnpqevyiRstnieRtlesarclvaGLygkiiiq......kelpiilytdeedeevlyP.nrqrcpll

DELYAKELATArvkQINEENKDFFQKLKKDTGVTEDITVNTVyTIEDPLFCEQAHNRTLPTwASNDVMLKLENLTNIGMAMLFG-----TKELARLKGGP
 . | .  ..|      .   .. ...... ...|.  .. | .. | .  ..||| . |    .||.  .|.     . .|.       ||  .|  |.
srayrsvrksa...islpGisedtkqiadvldiseekkldfv.slrDniaArlaHnlkvpp.ilkdvidliekhAveelvvlleggdrpekeilklsvGk

LVGKMISDMEKKSKNVTGTpIKFFMYSAHDTTLAAFMSALGVYNGKQSPYASAVGVELWEDDATKSFnVSIWFRNSTtQEVPYKlhlmdCSDMCGLERFK
.. .... .||. .. . .  |. .|||||||| . . ||||...|  |.|. | .||.||.| ..| | ..... . .... .      .|.. || ||
vlkeilenlekakekeipa.rklrLysaHDttlmtLLlalgvFDdkWPpfaadvileLyedkageyf.vrvlYqeke.lrlrgs.....eedlvPlekFk

ELVLDVI-PGNVEAECG
.|.  .. | . .||| 
allavlvlpkdyaaeCk
subfamily_HP2-Group1_pd Subfamily HP2-Group1 65-374 4e-26 83.3 In-house 93-417 (422) alignment 
Range on Protein: 65-374
Range on HMM: 93-417/422.0
GQLSKLGMQMQYGLGQFLGKRYQDTGFLNANYTRTEINIRSTDVDRCLMSAQSDLSGLYQPLPEMQFNpnisWQPIPVHTKPKENDYLlRTDGTSCPYYD
.||.  | . |   || | | | |||||....  .|. .|| |. | ..|||. . |.| .    . .     | ....|. |  | .  ..   ||   
aqltleGykqqelnGqilrkvyvdtGflkssldssevylrsddesrtilsaqalilGmypqdtkaedr....aqvvdlytrdklfdsi.eanadlcpkls

ELYAKELATARV-KQINEENKDFFQKLKKDTG-------------------VTEDITVNTVYTIEDPLFCEQAHNRTLPTWASNDVMLK-LENLTNIGMA
|   . | .    . ..   |.  ....|  |                   ||  . ....  . | |.  | || ..|   ..|.... |..|     .
eyntqflksdtwlnhlkgitkelllevskalGsnkslgsggcshtlylpiavtrkldidnledlvdclithqchnaaipdkltedlakrgldellyrsys

MLF--GTKELARLKggplVGKMISDMEKK-SKNVTGTPI-KFFMYSAHDTTLAAFMSALGVYNGKQSPYASAVGVELWEDDATKS-----FNVSIWFrNS
.|     .. ||      .| .. |. |.  . .||  . || .|| |||||  ..|||.| ..|  |||| . .||.|  .. .     . | . . | 
slkypsvekyarvG....iGfllkdiwkevnesltGedlrkfllysGhdttliqllsalnvdefkwppyasllllellevstapaastpqyavrvly.nG

TTqevpYKLHLMDCSDmCGLERFKELVLDVIPGNVEAECG
       || . |. . | .|.|.. .  ||| .   .| 
kl....kklpfcdane.csyeqfeaylstviphddaedck
subfamily_PXYLP1_pd Subfamily PXYLP1 47-356 1e-21 68.6 In-house 88-394 (419) alignment 
Range on Protein: 47-356
Range on HMM: 88-394/419.0
AQTFPTDPYREDSWPQgwGQLSKLGMQMQYGLGQFLGKRYQDT-GFL--NANYTRTEINIRSTDVDRCLmsaQSDLSGLYQPLPEMQfnpnisWQPIPVH
 ...|  |  |   ..  ||| . |.     .|..| | |  . ..|  . .... |... .|   | |   || |. ||  ||. .      .. | |.
lkslPllpnheriCel..gqLtqkGvvqhLevGdllrkvYakklklLlkpnelssDevvlettrkrrtl...qsalallygllpkak......lkairvr

TKPKENdYLlrTDGTSCPYYDELYaKELATARVKQINEENKDFFQKLK-KDTGVTEDITVNTVYTIEDPLFCEQAHNRTLPTWAS-------NDVMLKLE
..|  . .    .  |||  .... .|  . . . .  .. |  . .     |..   | | .    | | .   || .||   .        ||. ||.
espsva.fC..lgeCsCPallrkr.lekeadkqlLlrgkvldvmksvgetlkgtilqttlngisnpvdalltvlChnvslPcrreGcvepshvdvlhkla

NLTNIGMAMLFGTKELARLKGGPLVGKMISDMEKKSKNVTGTpiKFFMYSAHDTTLAAFMSALGVYNGKQSPYASAVGVELWEDDATKSFNVSIWFR-NS
.  .   |     |   .|.  ||. ...| | |  . |  .  || .||.|| ||   ..|||. ...   ||| .  ||.. .|.| . . . .    
delsqrsakksyyklsGllraypllrdivsrmlkiieGvdke..kfvlysghDvtlrplvaaLglseartiayasrlvfelyrreaskeyylrvlynGkD

TTQEVPYKL--HLMDCSDMCGLER
 ||.| .    . .   |.| || 
vtqkvdfCegdskrskkdlCPlen
subfamily_MINPP1_pd Subfamily MINPP1 66-181 1e-09 29.8 In-house 91-200 (420) alignment 
Range on Protein: 66-181
Range on HMM: 91-200/420.0
QLSKLGMQMQYGLGQFLGKRYQDtgFLNANYTRTEINIRSTDVDRCLMSAQSDLSGLyqplPEMQFNPNISWQPIPVHTKPKENDYLLRTDgTSCPYYDE
.| . | .  ..|.. | .|. .  .....| .......||.  |.. |||. . ||     | .   ..  ... . .. .|.| |||    ||. |..
slvaqgqeeleelakrlarrfpa..lfeevynpdsfsfastakkRtvksaqaFaeGL....setgevlgdefnivlqeiseqesdklLrff.dsCkkykn

-LYAKELATARVKQINE
 .. .||..   ... |
kvkknelnlkeeeefle
Lamp Lysosome-associated membrane glycoprotein (Lamp) 379-411 1.9e-06 14.5 Pfam-A 269-301 (306) alignment 
Range on Protein: 379-411
Range on HMM: 269-301/306.0
KNYTIPILIGTSLIALILVLIFVYLVCKGRHQE
..  .|| .|  |..|||. . .||. . |...
tsllvPiiVGaalaglilivLiaYligrrrshs