Phosphatase Gene PTPN1

Phosphatase Classification: Fold CC1: Superfamily CC1: Family PTP: Subfamily PTPN1: Gene PTPN1

Evolution

See evolution section on page of Subfamily PTPN1.

Functions

PTPN1 is perhaps the best understood classical PTP. It is a critical negative regulator of insulin and leptin signaling, as well as other receptor tyrosine kinases and cytokine receptors, and is known to undergo reversible oxidation (see review [1]). Recently, it has been reported that inactivation of PTP1B by reactive oxygen species is essential for oncogene-induced senescence (OIS), which prevents the progression of preneoplastic cells harboring oncogenic mutations [2].

References

1. Feldhammer M, Uetani N, Miranda-Saavedra D, and Tremblay ML. PTP1B: a simple enzyme for a complex world. Crit Rev Biochem Mol Biol. 2013 Sep-Oct;48(5):430-45. DOI:10.3109/10409238.2013.819830 |
2. Yang M, Haase AD, Huang FK, Coulis G, Rivera KD, Dickinson BC, Chang CJ, Pappin DJ, Neubert TA, Hannon GJ, Boivin B, and Tonks NK. Dephosphorylation of tyrosine 393 in argonaute 2 by protein tyrosine phosphatase 1B regulates gene silencing in oncogenic RAS-induced senescence. Mol Cell. 2014 Sep 4;55(5):782-90. DOI:10.1016/j.molcel.2014.07.018 |