Phosphatase Subfamily DSP19
Phosphatase Classification: Fold CC1: Superfamily CC1: Family DSP: Subfamily DSP19
DSP19 is a phosphatase subfamily widely found in eukaryotes but absent from fungi. It functions in the regulation of JNK signaling but the precise molecular mechanism is unclear.
Evolution
DSP19 subfamily is found in most eukaryotes except fungi (unpublished data from gOrtholog).
Domain
DSP19 has a single domain: phosphatase domain.
Function
Human DUSP19 (SKRP1) appears to play a specific role in the regulation of jun-kinase (JNK) signaling; however, the precise mechanism is unclear. DUSP19 interacts physically with the MAPK kinase (MAPKK) MKK7, a c-Jun N-terminal kinase (JNK) activator, and inactivates the MAPK JNK pathway [1]. DUSP19 also interacted with the MAPKKK, apoptosis signal-regulating kinase 1 (ASK1), but not with MAP kinase kinase kinase 1 (MEKK1) [2]
References
- Zama T, Aoki R, Kamimoto T, Inoue K, Ikeda Y, and Hagiwara M. A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway. Implication for the precise regulation of the particular MAPK pathway. J Biol Chem. 2002 Jun 28;277(26):23909-18. DOI:10.1074/jbc.M200837200 |
- Zama T, Aoki R, Kamimoto T, Inoue K, Ikeda Y, and Hagiwara M. Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway. J Biol Chem. 2002 Jun 28;277(26):23919-26. DOI:10.1074/jbc.M200838200 |
