Phosphatase Subfamily DSP23
Phosphatase Classification: Fold CC1: Superfamily CC1: Family DSP: Subfamily DSP23
DSP23 is a nuclear phosphatase found in metazoa but lost in most ecdysozoa.
Evolution
DSP23 is found in metazoa but lost in nematodes and most arthropods (unpublished data from gOrtholog). It has a single human member, DUSP23 (VHZ).
Domain
DSP23 has a single domain, the phosphatase domain. Sequence and structure show that it is the shortest known DSP [1].
Function
Human DUSP23 dephosphorylates Ser322 on GCM1 (Glial cells missing homolog 1), a transcription factor essential for placental development. The dephosphorylation promotes GCM1 acetylation [2].
DSP23 is also called VHZ for its similarity with VHR phosphatase. Different from MAP kinases phosphatases which negatively regulate MAP kinases such as JNK and p38, DSP23 has been reported to enhance activation of JNK and p38 [3]. Human DSP23 locates at centrosome in MCF-7 cells and is proposed to be involved in cell growth and human primary cancers. [4].
References
- Alonso A, Burkhalter S, Sasin J, Tautz L, Bogetz J, Huynh H, Bremer MC, Holsinger LJ, Godzik A, and Mustelin T. The minimal essential core of a cysteine-based protein-tyrosine phosphatase revealed by a novel 16-kDa VH1-like phosphatase, VHZ. J Biol Chem. 2004 Aug 20;279(34):35768-74. DOI:10.1074/jbc.M403412200 |
- Lin FY, Chang CW, Cheong ML, Chen HC, Lee DY, Chang GD, and Chen H. Dual-specificity phosphatase 23 mediates GCM1 dephosphorylation and activation. Nucleic Acids Res. 2011 Feb;39(3):848-61. DOI:10.1093/nar/gkq838 |
- Takagaki K, Satoh T, Tanuma N, Masuda K, Takekawa M, Shima H, and Kikuchi K. Characterization of a novel low-molecular-mass dual-specificity phosphatase-3 (LDP-3) that enhances activation of JNK and p38. Biochem J. 2004 Nov 1;383(Pt. 3):447-55. DOI:10.1042/BJ20040498 |
- Tang JP, Tan CP, Li J, Siddique MM, Guo K, Chan SW, Park JE, Tay WN, Huang ZY, Li WC, Chen J, and Zeng Q. VHZ is a novel centrosomal phosphatase associated with cell growth and human primary cancers. Mol Cancer. 2010 May 28;9:128. DOI:10.1186/1476-4598-9-128 |
