Difference between revisions of "Phosphatase Family OCA"
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| − | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_OCA|OCA]] | + | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_OCA|OCA]] |
| − | The OCA family is named after the five member genes in yeast (OCA1-5 = Oxidant-induced Cell-cycle Arrest). | + | The OCA family is named after the five member genes in yeast (OCA1-5 = Oxidant-induced Cell-cycle Arrest). The family is also called plant and fungi atypical (PFA)-DSPs <cite>Pulido07 Pulido11</cite>. |
| + | === Evolution === | ||
OCA is found in most eukaryotes other than eumetazoa. We have seen it in fungi, plants, protists, monosiga, and sponge. | OCA is found in most eukaryotes other than eumetazoa. We have seen it in fungi, plants, protists, monosiga, and sponge. | ||
| − | + | === Domain === | |
| + | OCA has a single domain, a phosphatase domain of fold CC1. | ||
| + | === Functions === | ||
| + | Yeast OCA members are involved in cell cycle arrest in response to oxidative damage<cite>Alic</cite>, in telomere capping <cite>lydall08</cite>, in actin organization <cite>Care</cite>. [[Gene_OCA3|OCA3]] has been shown to control intracellular localization of Gln3 (a phosphorylated transcriptional activator), in cooperation with Npr1 kinase <cite>Harashima08</cite>. | ||
| − | ===== | + | ===== References ===== |
<biblio> | <biblio> | ||
#Alic pmid=11408586 | #Alic pmid=11408586 | ||
Revision as of 23:55, 26 February 2015
Phosphatase Classification: Fold CC1: Superfamily CC1: OCA
The OCA family is named after the five member genes in yeast (OCA1-5 = Oxidant-induced Cell-cycle Arrest). The family is also called plant and fungi atypical (PFA)-DSPs [1, 2].
Contents
Evolution
OCA is found in most eukaryotes other than eumetazoa. We have seen it in fungi, plants, protists, monosiga, and sponge.
Domain
OCA has a single domain, a phosphatase domain of fold CC1.
Functions
Yeast OCA members are involved in cell cycle arrest in response to oxidative damage[3], in telomere capping [4], in actin organization [5]. OCA3 has been shown to control intracellular localization of Gln3 (a phosphorylated transcriptional activator), in cooperation with Npr1 kinase [6].
References
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Error fetching PMID 18166280:
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- Error fetching PMID 21409566:
- Error fetching PMID 11408586:
- Error fetching PMID 18845848:
- Error fetching PMID 15020461:
- Error fetching PMID 18166280:
