Difference between revisions of "Phosphatase Subfamily PRL"
From PhosphataseWiki
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| − | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_DSP|Family DSP]]: [[Phosphatase_Subfamily_PRL|Subfamily PRL]] | + | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_DSP|Family DSP]]: [[Phosphatase_Subfamily_PRL|Subfamily PRL]] |
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| − | ===== | + | |
| + | === Evolution === | ||
| + | PRL subfamily is present in animals, amoeba, and many basal eukaryotes, but is absent from fungi and plants ([http://resdev.gene.com/gOrtholog/view/cluster/MC0001030/overview unpublish data from gOrtholog]). | ||
| + | |||
| + | === Domain === | ||
| + | |||
| + | |||
| + | === Function === | ||
| + | PRL is short for Phosphatases of Regenerating Liver. There are three PRLs in human, PRL1, PRL2, PRL3, all of which have been identified as key contributors to metastasis in several human cancers <cite>tremblay14 Von-Hoff06</cite>. The molecular mechanisms of PRL phosphatases is reviewed at here <cite>kohn12</cite> in 2012, but it may play other roles as more works are going-on (e.g. <cite>tremblay14</cite>). | ||
| + | |||
| + | === References === | ||
<biblio> | <biblio> | ||
#Von-Hoff06 pmid=16275986 | #Von-Hoff06 pmid=16275986 | ||
Revision as of 05:07, 27 February 2015
Phosphatase Classification: Fold CC1: Superfamily CC1: Family DSP: Subfamily PRL
Evolution
PRL subfamily is present in animals, amoeba, and many basal eukaryotes, but is absent from fungi and plants (unpublish data from gOrtholog).
Domain
Function
PRL is short for Phosphatases of Regenerating Liver. There are three PRLs in human, PRL1, PRL2, PRL3, all of which have been identified as key contributors to metastasis in several human cancers [1, 2]. The molecular mechanisms of PRL phosphatases is reviewed at here [3] in 2012, but it may play other roles as more works are going-on (e.g. [1]).
References
- Hardy S, Uetani N, Wong N, Kostantin E, Labbé DP, Bégin LR, Mes-Masson A, Miranda-Saavedra D, and Tremblay ML. The protein tyrosine phosphatase PRL-2 interacts with the magnesium transporter CNNM3 to promote oncogenesis. Oncogene. 2015 Feb 19;34(8):986-95. DOI:10.1038/onc.2014.33 |
- Stephens BJ, Han H, Gokhale V, and Von Hoff DD. PRL phosphatases as potential molecular targets in cancer. Mol Cancer Ther. 2005 Nov;4(11):1653-61. DOI:10.1158/1535-7163.MCT-05-0248 |
- Rios P, Li X, and Köhn M. Molecular mechanisms of the PRL phosphatases. FEBS J. 2013 Jan;280(2):505-24. DOI:10.1111/j.1742-4658.2012.08565.x |
