Difference between revisions of "Phosphatase Subfamily PTPRC"
From PhosphataseWiki
| Line 9: | Line 9: | ||
PTPRC is found as a single-copy gene in all vertebrates, including the lamprey, but not in any invertebrate. | PTPRC is found as a single-copy gene in all vertebrates, including the lamprey, but not in any invertebrate. | ||
| − | ===Domain | + | ===Domain === |
PTPRC has twin intracellular PTP phosphatase domains, and extracellular FN3 domains, plus a CD45-specific and a PTP-N-terminal domain found specifically in PTPRC, as annotated by InterPro. CD45 is extensively alternatively spliced. | PTPRC has twin intracellular PTP phosphatase domains, and extracellular FN3 domains, plus a CD45-specific and a PTP-N-terminal domain found specifically in PTPRC, as annotated by InterPro. CD45 is extensively alternatively spliced. | ||
Revision as of 03:11, 11 March 2015
Phosphatase Classification: Fold CC1: Superfamily CC1: Family PTP: Subfamily PTPRC
PTPRC (CD45) is a vertebrate-specific receptor PTP involved in immune signaling.
Evolution
PTPRC is found as a single-copy gene in all vertebrates, including the lamprey, but not in any invertebrate.
Domain
PTPRC has twin intracellular PTP phosphatase domains, and extracellular FN3 domains, plus a CD45-specific and a PTP-N-terminal domain found specifically in PTPRC, as annotated by InterPro. CD45 is extensively alternatively spliced.
Functions
CD45 modulates immune function [1]. It is selectively expressed on lymphocytes and dephosphorylates and activates the src family tyrosine kinases lck, fyn and lyn in B and T cells.
