Difference between revisions of "Phosphatase Subfamily CUT"
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=== Evolution === | === Evolution === | ||
| − | This family is present throughout eukaryotes | + | This family is present throughout eukaryotes, mostly single-copy but with several duplications. It is lost from Drosophila but present in other arthropods. |
=== Domain === | === Domain === | ||
Revision as of 19:51, 21 March 2015
Phosphatase Classification: Fold HAD: Superfamily HAD: Family NagD: Subfamily CUT
Cut genes are related to other eukaryotic NagD phosphatases, but have not been shown to have protein phosphatase activity.
Evolution
This family is present throughout eukaryotes, mostly single-copy but with several duplications. It is lost from Drosophila but present in other arthropods.
Domain
CUT has a single domain, HAD domain.
Function
Cut proteins are localized to the mitochondria [1, 2]. CECR5, the human Cut gene, has been shown to associate with ICT1, a mitochondrial peptidyl-tRNA hydrolase [3] and yeast Cut (YKR070W) genetically interacts with PTH1, a related aminoacyl tRNA hydrolase. The Drosophila homolog, CG6094 was also seen to interact with NHP2, a protein associated with ribosome biogenesis and telomeres. A Neurospora homolog, cut-1 is expressed in a light-dependent manner and required for response to osmotic stress [4]. An PhD thesis reports that YKR070W shows phosphatase activity against sugar and glycerol phosphates (https://tspace.library.utoronto.ca/bitstream/1807/19048/1/Kuznetsova_Ekaterina_200911_PhD_thesis.pdf, p129).
References
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Error fetching PMID 20186120:
Error fetching PMID 16807008:
- Error fetching PMID 18029348:
- Error fetching PMID 16823961:
- Error fetching PMID 20186120:
- Error fetching PMID 16807008:
