Difference between revisions of "Phosphatase Subfamily SAC1"
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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_Sac|Family Sac]]: [[Phosphatase_Subfamily_SAC1|Subfamily SAC1]] | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_Sac|Family Sac]]: [[Phosphatase_Subfamily_SAC1|Subfamily SAC1]] | ||
| − | SAC1 is an integral membrane phosphoinositide phosphatase conserved in eukaryotes. | + | SAC1 is an integral membrane phosphoinositide phosphatase located in endoplasmic reticulum (ER) and golgi apparatus. SAC1 is conserved in eukaryotes. |
=== Evolution === | === Evolution === | ||
Revision as of 18:19, 15 April 2015
Phosphatase Classification: Fold CC1: Superfamily CC1: Family Sac: Subfamily SAC1
SAC1 is an integral membrane phosphoinositide phosphatase located in endoplasmic reticulum (ER) and golgi apparatus. SAC1 is conserved in eukaryotes.
Evolution
The SAC1 subfamily is conserved in eukaryotes. It is present in almost all the 203 eukaryotic genomes in gOrtholog database (internal).
Domain
The SAC1 subfamily has a single structural domain, SAC phosphatase domain. It also has a tail which contains localization signal and motifs interacting with other proteins (e.g. coatomer I complex [1]).
Function
The members of the SAC1 subfamily are integral membrane phosphoinositide phosphatases that play evolutionary conserved roles in eukaryotic cell physiology [2]. It locates in the endoplasmic reticulum (ER) and the Golgi apparatus in yeast and mammals.
SAC1 is best characterized in Saccharomyces cerevisiae [3, 4]. Yeast SAC1 mutants display a wide array of phenotypes including inositol auxotrophy, cold sensitivity, secretory defects, disturbed ATP transport into the ER, or suppression of actin gene mutations.
In mammals, it regulates Golgi membrane morphology and mitotic spindle organization [5]. The human SAC1 is widely expressed in different tissues (see GTEx). It interacts with the coatomer I complex via a putative COPI interaction motif (KXKXX) at its C terminus in a manner dependent on its catalytic activity [1].
References
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