Difference between revisions of "Phosphatase Subfamily INPP5F"
From PhosphataseWiki
(→Function) |
|||
| Line 10: | Line 10: | ||
=== Function === | === Function === | ||
| − | Human INPP5F (SAC2) is expressed in most tissues and particularly abundant in brain (see [http://www.gtexportal.org/home/gene/INPP5F GTEx]). | + | Human INPP5F (SAC2) is expressed in most tissues and particularly abundant in brain (see [http://www.gtexportal.org/home/gene/INPP5F GTEx]). It has 5-phosphatase activity specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate <cite>Minagawa01</cite>. |
=== References === | === References === | ||
<biblio> | <biblio> | ||
</biblio> | </biblio> | ||
Revision as of 20:58, 15 April 2015
Phosphatase Classification: Fold CC1: Superfamily CC1: Family Sac: Subfamily INPP5F (SAC2)
Evolution
The INPP5F (SAC2) subfamily is found in most metazoa and fungi. It is also found in a few plants and basal eukaryotes (see gOrtholog database (internal)).
Domain
The INPP5F (SAC2) subfamily has a single structural domain, SAC phosphatase domain.
Function
Human INPP5F (SAC2) is expressed in most tissues and particularly abundant in brain (see GTEx). It has 5-phosphatase activity specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate [1].
