Difference between revisions of "Phosphatase Subfamily INPP5F"
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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_Sac|Family Sac]]: [[Phosphatase_Subfamily_INPP5F|Subfamily INPP5F]] (SAC2) | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_Sac|Family Sac]]: [[Phosphatase_Subfamily_INPP5F|Subfamily INPP5F]] (SAC2) | ||
| + | INPP5F (SAC2) is a phosphoinositide phosphatase in the endocytic pathway. It is conserved in metazoa and fungi and is also found in a few plants and basal eukaryotes. | ||
=== Evolution === | === Evolution === | ||
Revision as of 21:15, 15 April 2015
Phosphatase Classification: Fold CC1: Superfamily CC1: Family Sac: Subfamily INPP5F (SAC2)
INPP5F (SAC2) is a phosphoinositide phosphatase in the endocytic pathway. It is conserved in metazoa and fungi and is also found in a few plants and basal eukaryotes.
Evolution
The INPP5F (SAC2) subfamily is found in most metazoa and fungi. It is also found in a few plants and basal eukaryotes (see gOrtholog database (internal)).
Domain
The INPP5F (SAC2) subfamily has a structural domain, SAC phosphatase domain. It may have a putative PH domain [1].
Function
Human INPP5F (SAC2) is expressed in most tissues and particularly abundant in brain (see GTEx). It has 5-phosphatase activity specific for phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3)[2]. It also has 4-phosphatase activity toward PI(4,5)P2) in the endocytic pathway [1, 3]. It cooperates with OCRL, a 5-phosphatase, in the sequential dephosphorylation of PI(4,5)P2 at the 4 and 5 position of inositol in a partnership that mimics that of the two phosphatase modules of synaptojanin [3].
References
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