Difference between revisions of "Phosphatase Family OCA"
(→Evolution) |
|||
| Line 6: | Line 6: | ||
=== Evolution === | === Evolution === | ||
| − | OCA is found in | + | The OCA family is found in many eukaryotes, including fungi, plants, protists, monosiga, and sponge. It is absent from most eumetazoa, but it is found in purple urchin, lancet, ghostshark (''Callorhinchus milii''), ''Capitella teleta'', owl limpet (''Lottia gigantea''), leech (''Helobdella robusta''). |
=== Domain === | === Domain === | ||
Revision as of 17:35, 27 July 2015
Phosphatase Classification: Fold CC1: Superfamily CC1: Family OCA
The OCA family is named after the five member genes in yeast (OCA1-5 = Oxidant-induced Cell-cycle Arrest). The family is also called plant and fungi atypical (PFA)-DSPs [1, 2].
Evolution
The OCA family is found in many eukaryotes, including fungi, plants, protists, monosiga, and sponge. It is absent from most eumetazoa, but it is found in purple urchin, lancet, ghostshark (Callorhinchus milii), Capitella teleta, owl limpet (Lottia gigantea), leech (Helobdella robusta).
Domain
OCA has a single domain, a phosphatase domain of fold CC1.
Functions
Yeast OCA members are involved in cell cycle arrest in response to oxidative damage[3], in telomere capping [4], in actin organization [5]. OCA3 has been shown to control intracellular localization of Gln3 (a phosphorylated transcriptional activator), in cooperation with Npr1 kinase [6].
References
Error fetching PMID 15020461:
Error fetching PMID 17976645:
Error fetching PMID 21409566:
Error fetching PMID 18845848:
Error fetching PMID 18166280:
- Error fetching PMID 17976645:
- Error fetching PMID 21409566:
- Error fetching PMID 11408586:
- Error fetching PMID 18845848:
- Error fetching PMID 15020461:
- Error fetching PMID 18166280:
