Difference between revisions of "Phosphatase Subfamily PTPRG Tech Note"
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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]:[[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPRG|Subfamily PTPRG]]: [[Phosphatase_Subfamily_PTPRG_Tech_Note|Technical notes]] | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]:[[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPRG|Subfamily PTPRG]]: [[Phosphatase_Subfamily_PTPRG_Tech_Note|Technical notes]] | ||
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| + | === The gain of N-terminal Carbonic anhydrase (CA) domain === | ||
| + | We BLASTed the N-terminal CA domain sequence determined by CDD (1-275 of human PTPRG) against i) all eukaryotes, ii) animals except vertebrates, iii) deuterostomes except vertebrates and iv) vertebrates, in a narrow-down approach. In invertebrates, all of the hits have a single CA domain, rather than fn3 or phosphatase domain found in PTPRG. We found CA-containing PTPRG in almost all vertebrates (lamprey lacks CA domain due to the incomplete gene model). In sum, the CA domain was gained in vertebrates. | ||
Revision as of 17:58, 14 October 2015
Phosphatase Classification: Fold CC1:Superfamily CC1: Family PTP: Subfamily PTPRG: Technical notes
The gain of N-terminal Carbonic anhydrase (CA) domain
We BLASTed the N-terminal CA domain sequence determined by CDD (1-275 of human PTPRG) against i) all eukaryotes, ii) animals except vertebrates, iii) deuterostomes except vertebrates and iv) vertebrates, in a narrow-down approach. In invertebrates, all of the hits have a single CA domain, rather than fn3 or phosphatase domain found in PTPRG. We found CA-containing PTPRG in almost all vertebrates (lamprey lacks CA domain due to the incomplete gene model). In sum, the CA domain was gained in vertebrates.
