Difference between revisions of "Phosphatase Fold CC1"
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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]] | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]] | ||
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Fold CC1 has a single superfamily [[Phosphatase_Superfamily_CC1|CC1]]. | Fold CC1 has a single superfamily [[Phosphatase_Superfamily_CC1|CC1]]. | ||
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| + | === Comparing the secondary structure across families === | ||
| + | We carried out structural alignment analysis of the crystal structures of five phosphatases of different families (Paladin and OCA has no structure), including human DUSP3 (DSP), PTEN (PTEN), PTPN1 (PTP), MTMR2 (myotubularin) and yeast Sac1p (Sac) (family names in parentheses). We compared the secondary structures and identified the common and family-specific secondary structures (SSs). | ||
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| + | All CC1 families share the same SSs combination of BBHBBHBHHH (B - sheet, H - helix). The families have different N-terminal SSs. The sheets and helices are inserted at: | ||
| + | * B2-H1: Sac1p | ||
| + | * H1-B3: MTMR2 | ||
| + | * B3-B4: PTPN1, MTMR2, Sac1p | ||
| + | * B4-H2: PTPN1, MTMR2 | ||
| + | * H2-B5: Sac1p | ||
| + | * H3-H4: MTMR2 | ||
| + | |||
| + | MTMR2 has additional 4 helices at C terminus. | ||
Revision as of 20:38, 28 October 2015
Phosphatase Classification: Fold CC1
Fold CC1 has a single superfamily CC1.
Comparing the secondary structure across families
We carried out structural alignment analysis of the crystal structures of five phosphatases of different families (Paladin and OCA has no structure), including human DUSP3 (DSP), PTEN (PTEN), PTPN1 (PTP), MTMR2 (myotubularin) and yeast Sac1p (Sac) (family names in parentheses). We compared the secondary structures and identified the common and family-specific secondary structures (SSs).
All CC1 families share the same SSs combination of BBHBBHBHHH (B - sheet, H - helix). The families have different N-terminal SSs. The sheets and helices are inserted at:
- B2-H1: Sac1p
- H1-B3: MTMR2
- B3-B4: PTPN1, MTMR2, Sac1p
- B4-H2: PTPN1, MTMR2
- H2-B5: Sac1p
- H3-H4: MTMR2
MTMR2 has additional 4 helices at C terminus.
