Difference between revisions of "Phosphatase Superfamily CC1"
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[[Phosphatase classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]] | [[Phosphatase classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]] | ||
| − | CC1 (or Cysteine-based, group 1) is the largest phosphatase superfamily. It consists of | + | CC1 (or Cysteine-based, group 1) is the largest phosphatase superfamily. It consists of the families in human as below: |
| − | + | * [[Phosphatase_Family_PTP|PTP]] (Protein Tyrosine Phosphatase) - generally tyrosine-specific phosphatases. | |
| − | + | * [[Phosphatase_Family_DSP|DSP]] (Dual Specificity Phosphatases) - diverse substrates, from tyrosine, serine, threonine to small molecules. | |
| − | + | * [[Phosphatase_Family_PTEN|PTEN]] - phosphoinositide phosphatases. | |
| − | + | * [[Phosphatase_Family_Myotubularin|Myotubularin]] - phosphoinositide phosphatases. | |
| + | |||
| + | * [[Phosphatase_Family_Sac|SAC]] - phosphoinositide phosphatases. | ||
| + | |||
| + | * [[Phosphatase_Family_Paladin|Paladin]] - catalytically inactive phosphatase. | ||
Fungi, plants and many protists also have the [[Phosphatase_Family_OCA|OCA]] family. | Fungi, plants and many protists also have the [[Phosphatase_Family_OCA|OCA]] family. | ||
| − | + | CC1 shares a Cys-based catalytic motif, CX5R with another two superfamilies [[Phosphatase_Superfamily_CC2I| CC2]] and [[Phosphatase_Superfamily_CC3|CC3]], but it has distinct structure from them. | |
Latest revision as of 20:23, 14 August 2016
Phosphatase classification: Fold CC1: Superfamily CC1
CC1 (or Cysteine-based, group 1) is the largest phosphatase superfamily. It consists of the families in human as below:
- PTP (Protein Tyrosine Phosphatase) - generally tyrosine-specific phosphatases.
- DSP (Dual Specificity Phosphatases) - diverse substrates, from tyrosine, serine, threonine to small molecules.
- PTEN - phosphoinositide phosphatases.
- Myotubularin - phosphoinositide phosphatases.
- SAC - phosphoinositide phosphatases.
- Paladin - catalytically inactive phosphatase.
Fungi, plants and many protists also have the OCA family.
CC1 shares a Cys-based catalytic motif, CX5R with another two superfamilies CC2 and CC3, but it has distinct structure from them.
