Difference between revisions of "Phosphatase Family HP2"

Revision as of 22:16, 1 January 2015

Phosphatase Classification: Fold HP: Superfamily HP (histidine phosphatase): Family HP, branch 2

Refer to Pfam ID PF00328 for general information.

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 === Subfamilies ===
-====== ACPP ======
+====== [[Phosphatase_Subfamily_ACP2|Subfamily ACP2]] ======
-[http://www.ncbi.nlm.nih.gov/gene/55 ACPP] (acid phosphatase, prostate) is a prostate epithelium-specific differentiation antigen, and is decreased in prostate carcinomas. It has been show to downregulate prostate cell growth by dephosphorylating phosphotyrosine on c-ErbB-2, an oncoprotein in prostate cells <cite>ACPP_2</cite>. His-12 and Asp-258 of ACPP, but not Cys-183 or Cys-281, are required for the phosphatase activity <cite>ACPP_1</cite>. ACPP and its paralog [http://www.ncbi.nlm.nih.gov/gene/53 ACP2] is found in metazoan, choanoflagellida, amoebozoa and some protists, but is absent from fungi and plants.
 ====== [[Phosphatase_Subfamily_PXYLP1|PXYLP1]] (ACPL2) ======