Difference between revisions of "Phosphatase Subfamily PTPRC"
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| − | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPRC|Subfamily PTPRC]] | + | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPRC|Subfamily PTPRC]] |
Revision as of 21:53, 19 February 2015
Phosphatase Classification: Fold CC1: Superfamily CC1: Family PTP: Subfamily PTPRC
PTPRC (CD45) is a vertebrate-specific receptor PTP involved in immune signaling.
Evolution
PTPRC is found as a single-copy gene in all vertebrates, including the lamprey, but not in any invertebrate.
Domain Structure
PTPRC has twin intracellular PTP phosphatase domains, and extracellular FN3 domains, plus a CD45-specific and a PTP-N-terminal domain found specifically in PTPRC, as annotated by InterPro. CD45 is extensively alternatively spliced.
Functions
CD45 modulates immune function [1]. It is selectively expressed on lymphocytes and dephosphorylates and activates the src family tyrosine kinases lck, fyn and lyn in B and T cells.
