Difference between revisions of "Phosphatase Subfamily PTPRD"
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===Evolution=== | ===Evolution=== | ||
| − | PTPRD subfamily is found in holozoan (metazoan plus it closest relative choanoflagellate). PTPRD subfamily has three gene members in most vertebrates: PTPRD, PTPRF and PTPRS. It has single member in most invertebrate metazoan. Interestingly, it | + | PTPRD subfamily is found in holozoan (metazoan plus it closest relative choanoflagellate). PTPRD subfamily has three gene members in most vertebrates: PTPRD, PTPRF and PTPRS. It has single member in most invertebrate metazoan. Interestingly, it greatly expanded in sponge. |
===Domain Structure=== | ===Domain Structure=== | ||
Revision as of 20:03, 20 February 2015
Phosphatase Classification: Fold CC1: Superfamily CC1: Family PTP: Subfamily PTPRD
PTPRC (CD45) is a vertebrate-specific receptor PTP involved in immune signaling.
Evolution
PTPRD subfamily is found in holozoan (metazoan plus it closest relative choanoflagellate). PTPRD subfamily has three gene members in most vertebrates: PTPRD, PTPRF and PTPRS. It has single member in most invertebrate metazoan. Interestingly, it greatly expanded in sponge.
Domain Structure
PTPRC has twin intracellular PTP phosphatase domains, and extracellular FN3 domains, plus a CD45-specific and a PTP-N-terminal domain found specifically in PTPRC, as annotated by InterPro. CD45 is extensively alternatively spliced.
Functions
CD45 modulates immune function [1]. It is selectively expressed on lymphocytes and dephosphorylates and activates the src family tyrosine kinases lck, fyn and lyn in B and T cells.
References
- Error fetching PMID 25128530:
