Difference between revisions of "Phosphatase Family Paladin"
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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_Paladin|Family Paladin]] | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_Paladin|Family Paladin]] | ||
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| + | The phosphatase family Paladin has one [[Phosphatase_Subamily_Paladin|subfamily Paladin]]. | ||
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| + | === Evolution === | ||
| + | Paladins are found in vertebrates and early metazoa such as sponge, trichoplax and nematostella but absent from arthropoda and nematoda. Paladins are also found in most plants and a small number of fungi (see internal database [http://resdev.gene.com/gOrtholog/view/cluster/MC0005718/overview gOrtholog]). | ||
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| + | === Domain === | ||
| + | The Paladin subfamily has a single domain, which lacks the cysteine residue at Cx5R catalytic motif common among CC1-fold phosphatases. | ||
| + | |||
| + | === Function === | ||
| + | Little is known about Paladin's molecular function. It regulates phosphorylation status in neural crest cell formation and migration in chicken <cite>Roffers-Agarwal12</cite>, but it lacks the residue necessary for phosphatase activity. | ||
| + | |||
| + | === References === | ||
| + | <biblio> | ||
| + | #Roffers-Agarwal12 pmid=22926139 | ||
| + | </biblio> | ||
Revision as of 21:53, 14 April 2015
Phosphatase Classification: Fold CC1: Superfamily CC1: Family Paladin
The phosphatase family Paladin has one subfamily Paladin.
Contents
[hide]Evolution
Paladins are found in vertebrates and early metazoa such as sponge, trichoplax and nematostella but absent from arthropoda and nematoda. Paladins are also found in most plants and a small number of fungi (see internal database gOrtholog).
Domain
The Paladin subfamily has a single domain, which lacks the cysteine residue at Cx5R catalytic motif common among CC1-fold phosphatases.
Function
Little is known about Paladin's molecular function. It regulates phosphorylation status in neural crest cell formation and migration in chicken [1], but it lacks the residue necessary for phosphatase activity.
