Difference between revisions of "Phosphatase Subfamily egg"
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=== Function === | === Function === | ||
| − | + | In ''C. elegans'', all three members are predicted to be catalytically inactive as the replacements at cysteine and/or arginine at Cx5R motif. Egg-4 and egg-5 functions in controlling the oocyte- to-zygote transition by regulating signaling by the DYRK family kinase MBK-2. Egg-4/egg-5 binds to MBK-2 at the substrate-binding groove of the kinase, and inhibits the ability of the kinase to bind and phosphorylate substrates, thereby inhibiting downstream signaling <cite> Cheng09 , Parry09, Tonks09 </cite>. | |
=== References === | === References === | ||
<biblio> | <biblio> | ||
| − | + | #Cheng09 pmid=19879842 | |
| + | #Parry09 pmid=19879147 | ||
| + | #Tonks09 pmid=19879835 | ||
</biblio> | </biblio> | ||
Revision as of 17:27, 29 May 2015
Phosphatase Classification: Fold CC1: Superfamily CC1: Family PTP: Subfamily Egg
Evolution
The eak subfamily is nematode specific. C. elegans has three members: egg-3, egg-4, egg-5.
Domain
The egg subfamily has a single structural domain: the phosphatase domain of CC1 fold.
Function
In C. elegans, all three members are predicted to be catalytically inactive as the replacements at cysteine and/or arginine at Cx5R motif. Egg-4 and egg-5 functions in controlling the oocyte- to-zygote transition by regulating signaling by the DYRK family kinase MBK-2. Egg-4/egg-5 binds to MBK-2 at the substrate-binding groove of the kinase, and inhibits the ability of the kinase to bind and phosphorylate substrates, thereby inhibiting downstream signaling [1, 2, 3].
References
- Cheng KC, Klancer R, Singson A, and Seydoux G. Regulation of MBK-2/DYRK by CDK-1 and the pseudophosphatases EGG-4 and EGG-5 during the oocyte-to-embryo transition. Cell. 2009 Oct 30;139(3):560-72. DOI:10.1016/j.cell.2009.08.047 |
- Parry JM, Velarde NV, Lefkovith AJ, Zegarek MH, Hang JS, Ohm J, Klancer R, Maruyama R, Druzhinina MK, Grant BD, Piano F, and Singson A. EGG-4 and EGG-5 Link Events of the Oocyte-to-Embryo Transition with Meiotic Progression in C. elegans. Curr Biol. 2009 Nov 3;19(20):1752-7. DOI:10.1016/j.cub.2009.09.015 |
- Tonks NK. Pseudophosphatases: grab and hold on. Cell. 2009 Oct 30;139(3):464-5. DOI:10.1016/j.cell.2009.10.008 |
