Difference between revisions of "Phosphatase Subfamily MTMR5"
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Human MTMR5 interact with MTMR2 (see [[Phosphatase_Subfamily_MTMR1|MTMR1 subfamily]]) via its coiled-coil domain and mutations in the coiled-coil domain of either MTMR2 or MTMR5 abrogate this interaction. Through this interaction, MTMR5 increases the enzymatic activity of MTMR2 and dictates its subcellular localization <cite>kim03</cite>. This is a good example of inactive phosphatase functions as regulator of active phosphatase. | Human MTMR5 interact with MTMR2 (see [[Phosphatase_Subfamily_MTMR1|MTMR1 subfamily]]) via its coiled-coil domain and mutations in the coiled-coil domain of either MTMR2 or MTMR5 abrogate this interaction. Through this interaction, MTMR5 increases the enzymatic activity of MTMR2 and dictates its subcellular localization <cite>kim03</cite>. This is a good example of inactive phosphatase functions as regulator of active phosphatase. | ||
| − | + | ===Disease=== | |
| + | Mice deficient for MTMR5 exhibited male infertility characterized by azoospermia <cite>firestein02</cite>. | ||
===References=== | ===References=== | ||
<biblio> | <biblio> | ||
#kim03 pmid=12668758 | #kim03 pmid=12668758 | ||
| + | #firestein pmid=11994405 | ||
</biblio> | </biblio> | ||
Revision as of 23:59, 30 December 2014
Phosphatase Classification: FoldCC1: Superfamily CC1: Family Myotubularin: Subfamily MTMR5 (SBF)
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Evolution
MTMR5 subfamily is found throughout metazoan. It consists of two members in human, MTMR5 and MTMR13, also called SBF1 and SBF2, respectively. In fruit fly and C elegans, a single copy is found.
Domain Structure
MTMR5 subfamily has a DENN domain, PH/GRAM domain, phosphatase domain, coiled-coil domain and PH domain. The GRAM domain is similar to PH domain in structure and is found in membrane-associated proteins.
Catalytic activity and functions
MTMR5 subfamily is conservatively inactive in metazoan.
Human MTMR5 interact with MTMR2 (see MTMR1 subfamily) via its coiled-coil domain and mutations in the coiled-coil domain of either MTMR2 or MTMR5 abrogate this interaction. Through this interaction, MTMR5 increases the enzymatic activity of MTMR2 and dictates its subcellular localization [1]. This is a good example of inactive phosphatase functions as regulator of active phosphatase.
Disease
Mice deficient for MTMR5 exhibited male infertility characterized by azoospermia [2].
References
- Kim SA, Vacratsis PO, Firestein R, Cleary ML, and Dixon JE. Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4492-7. DOI:10.1073/pnas.0431052100 |
- Firestein R, Nagy PL, Daly M, Huie P, Conti M, and Cleary ML. Male infertility, impaired spermatogenesis, and azoospermia in mice deficient for the pseudophosphatase Sbf1. J Clin Invest. 2002 May;109(9):1165-72. DOI:10.1172/JCI12589 |
