Difference between revisions of "Phosphatase Subfamily SCP"
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| − | + | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_HAD|Fold HAD]]: [[Phosphatase_Superfamily_HAD|Superfamily HAD]]: [[Phosphatase_Family_FCP|Family FCP]]: [[Phosphatase_Subfamily_SCP|Subfamily SCP]] | |
| − | == Introduction == | + | |
| + | === Introduction === | ||
SCP is named after Small CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase. This subfamily has three members in human, SCP1 (or CTDSP1), SCP2 (or CTDSP2), and SCP3 (or CTDSPL). They are present in neuronal progenitor cells and nonneuronal cells and targets neuronal genes by interacting with the REST/NRSF complext. The SCP1 is a transcriptional corepressor for inhibiting neuronal gene transcription in non-neuronal cells. For its molecular function, the SCP1 prefers to dephosphorylate pSer5 at CTD <cite>Zhang06</cite>. | SCP is named after Small CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase. This subfamily has three members in human, SCP1 (or CTDSP1), SCP2 (or CTDSP2), and SCP3 (or CTDSPL). They are present in neuronal progenitor cells and nonneuronal cells and targets neuronal genes by interacting with the REST/NRSF complext. The SCP1 is a transcriptional corepressor for inhibiting neuronal gene transcription in non-neuronal cells. For its molecular function, the SCP1 prefers to dephosphorylate pSer5 at CTD <cite>Zhang06</cite>. | ||
| − | == Substrates and Related Kinases == | + | === Substrates and Related Kinases === |
See [[CTD_Phosphorylation|Phosphorylation of RNA polymerase II C-terminal domain]]. | See [[CTD_Phosphorylation|Phosphorylation of RNA polymerase II C-terminal domain]]. | ||
| − | == Evolutionary History == | + | === Evolutionary History === |
SCP is conserved from yeast to human. | SCP is conserved from yeast to human. | ||
| − | == Domain Combination = | + | === Domain Combination === |
| − | + | ||
| − | + | ||
| − | + | ||
| − | == | + | === Catalytic activity === |
Revision as of 04:00, 1 January 2015
Phosphatase Classification: Fold HAD: Superfamily HAD: Family FCP: Subfamily SCP
Contents
Introduction
SCP is named after Small CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase. This subfamily has three members in human, SCP1 (or CTDSP1), SCP2 (or CTDSP2), and SCP3 (or CTDSPL). They are present in neuronal progenitor cells and nonneuronal cells and targets neuronal genes by interacting with the REST/NRSF complext. The SCP1 is a transcriptional corepressor for inhibiting neuronal gene transcription in non-neuronal cells. For its molecular function, the SCP1 prefers to dephosphorylate pSer5 at CTD [1].
Substrates and Related Kinases
See Phosphorylation of RNA polymerase II C-terminal domain.
Evolutionary History
SCP is conserved from yeast to human.
Domain Combination
Catalytic activity
References
- Error fetching PMID 17157258:
Links
Human CTDSP1, CTDSP2, and CTDSPL from NCBI Gene
