Difference between revisions of "Phosphatase Family HP2"
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[http://www.ncbi.nlm.nih.gov/gene/55 ACPP] (acid phosphatase, prostate) is a prostate epithelium-specific differentiation antigen, and is decreased in prostate carcinomas. It has been show to downregulate prostate cell growth by dephosphorylating phosphotyrosine on c-ErbB-2, an oncoprotein in prostate cells <cite>ACPP_2</cite>. His-12 and Asp-258 of ACPP, but not Cys-183 or Cys-281, are required for the phosphatase activity <cite>ACPP_1</cite>. ACPP and its paralog [http://www.ncbi.nlm.nih.gov/gene/53 ACP2] is found in metazoan, choanoflagellida, amoebozoa and some protists, but is absent from fungi and plants. | [http://www.ncbi.nlm.nih.gov/gene/55 ACPP] (acid phosphatase, prostate) is a prostate epithelium-specific differentiation antigen, and is decreased in prostate carcinomas. It has been show to downregulate prostate cell growth by dephosphorylating phosphotyrosine on c-ErbB-2, an oncoprotein in prostate cells <cite>ACPP_2</cite>. His-12 and Asp-258 of ACPP, but not Cys-183 or Cys-281, are required for the phosphatase activity <cite>ACPP_1</cite>. ACPP and its paralog [http://www.ncbi.nlm.nih.gov/gene/53 ACP2] is found in metazoan, choanoflagellida, amoebozoa and some protists, but is absent from fungi and plants. | ||
| − | ====== PXYLP1 ====== | + | ====== [[Phosphatase_Subfamily_PXYLP1|PXYLP1]] ====== |
| − | [http://www.ncbi.nlm.nih.gov/gene/?term=92370 PXYLP1] dephosphorylates [http://en.wikipedia.org/wiki/Xylose xylose], a sugar, in the glycosaminoglycan-protein linkage region of proteoglycans <cite>koike14</cite>. It is found in most metazoan, absent from fungi, plants and most protists, but ''Entamoeba histolytica'' and ''Emiliania huxleyi'' have PXYLP1 like genes. | + | [http://www.ncbi.nlm.nih.gov/gene/?term=92370 PXYLP1] dephosphorylates [http://en.wikipedia.org/wiki/Xylose xylose], a sugar, in the glycosaminoglycan-protein linkage region of proteoglycans <cite>koike14</cite>. It is found in most metazoan, absent from fungi, plants and most protists, but ''Entamoeba histolytica'' and ''Emiliania huxleyi'' have PXYLP1 like genes. |
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===References=== | ===References=== | ||
Revision as of 21:31, 1 January 2015
Phosphatase Classification: Fold HP: Superfamily HP (histidine phosphatase): Family HP, branch 2
Refer to Pfam ID PF00328 for general information.
Contents
Subfamilies
ACPP
ACPP (acid phosphatase, prostate) is a prostate epithelium-specific differentiation antigen, and is decreased in prostate carcinomas. It has been show to downregulate prostate cell growth by dephosphorylating phosphotyrosine on c-ErbB-2, an oncoprotein in prostate cells [1]. His-12 and Asp-258 of ACPP, but not Cys-183 or Cys-281, are required for the phosphatase activity [2]. ACPP and its paralog ACP2 is found in metazoan, choanoflagellida, amoebozoa and some protists, but is absent from fungi and plants.
PXYLP1
PXYLP1 dephosphorylates xylose, a sugar, in the glycosaminoglycan-protein linkage region of proteoglycans [3]. It is found in most metazoan, absent from fungi, plants and most protists, but Entamoeba histolytica and Emiliania huxleyi have PXYLP1 like genes.
References
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Error fetching PMID 24425863:
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- Error fetching PMID 11067847:
- Error fetching PMID 24425863:
