Difference between revisions of "Phosphatase Subfamily PXYLP1"
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=== Evolution === | === Evolution === | ||
| − | + | PXYLP1 is found in bilateria, but ''Entamoeba histolytica'' and ''Emiliania huxleyi'' have PXYLP1 like genes. | |
=== Domain === | === Domain === | ||
| − | + | PXYLP1 has a N-terminal transmembrane region and C-terminal phosphatase domain. | |
=== Functions === | === Functions === | ||
| − | + | [http://www.ncbi.nlm.nih.gov/gene/?term=92370 Human PXYLP1] dephosphorylates [http://en.wikipedia.org/wiki/Xylose xylose], a sugar, in the glycosaminoglycan-protein linkage region of proteoglycans . In collaboration with kinase FAM20B, it regulates the transient phosphorylation of the Xyl residue in the glycosaminoglycan-protein linkage region, which controls the formation of glycosaminoglycan chains of proteoglycans <cite>koike14</cite>. | |
=== References === | === References === | ||
| + | <biblio> | ||
| + | #koike14 pmid=24425863 | ||
| + | </biblio> | ||
Revision as of 21:51, 1 January 2015
Phosphatase Classification: Fold HP: Superfamily HP (histidine phosphatase): Family HP, branch 2: PXYLP1
Contents
Evolution
PXYLP1 is found in bilateria, but Entamoeba histolytica and Emiliania huxleyi have PXYLP1 like genes.
Domain
PXYLP1 has a N-terminal transmembrane region and C-terminal phosphatase domain.
Functions
Human PXYLP1 dephosphorylates xylose, a sugar, in the glycosaminoglycan-protein linkage region of proteoglycans . In collaboration with kinase FAM20B, it regulates the transient phosphorylation of the Xyl residue in the glycosaminoglycan-protein linkage region, which controls the formation of glycosaminoglycan chains of proteoglycans [1].
