Difference between revisions of "Phosphatase Subfamily PTPRD"
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===Domain Structure=== | ===Domain Structure=== | ||
| − | + | All three members of PTPRD subfamily in human has twin intracellular PTP phosphatase domains, and extracellular Ig domains and FN3 domains. Each of them have multiple alternative splicing isoforms. | |
===Functions=== | ===Functions=== | ||
Revision as of 20:42, 20 February 2015
Phosphatase Classification: Fold CC1: Superfamily CC1: Family PTP: Subfamily PTPRD
PTPRC (CD45) is a vertebrate-specific receptor PTP involved in immune signaling.
Evolution
PTPRD subfamily is found in holozoan (metazoan plus it closest relative choanoflagellate). PTPRD subfamily has three gene members in most vertebrates: PTPRD, PTPRF and PTPRS. It has single member in most invertebrate metazoan. Interestingly, it greatly expanded in sponge.
Domain Structure
All three members of PTPRD subfamily in human has twin intracellular PTP phosphatase domains, and extracellular Ig domains and FN3 domains. Each of them have multiple alternative splicing isoforms.
Functions
CD45 modulates immune function [1]. It is selectively expressed on lymphocytes and dephosphorylates and activates the src family tyrosine kinases lck, fyn and lyn in B and T cells.
