Difference between revisions of "Phosphatase Subfamily CDKN3"
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=== Function === | === Function === | ||
Revision as of 04:51, 27 February 2015
Phosphatase Classification: Fold CC1: Superfamily CC1: Family DSP: Subfamily CDKN3
CDKN3 is a chordate-specific subfamily targeting threonine Cyclin-dependent kinases (CDKs) CDK1/CDC2 and CDK2.
Evolution
CDKN3 is found chordate.
Domain
CDKN3 has a single domain: phosphatase domain.
Function
CDKN3 is a cell cycle regulator. It dephosphorylates threonine-161 of CDC2/CDK1 during mitotic exit [1, 2]. CDKN3 also dephosphorylates threonine-160 CDK2 at the G1 to S transition but showed a preference for CDC2 [1, 3, 4].
CDKN3 is involved in cancer, but its role is controversial. CDKN3 acts as an oncogene in human hepatocellular carcinoma [5]. CDKN3 is over-expressed in renal cancer cells [6], breast and prostate cancer [7]. However, CDKN3 protein is down-regulated in brain tumors [2].
References
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