Difference between revisions of "Phosphatase Subfamily DSP14"
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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_DSP|Family DSP]]: [[Phosphatase_Subfamily_DSP14|Subfamily DSP14]] | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_DSP|Family DSP]]: [[Phosphatase_Subfamily_DSP14|Subfamily DSP14]] | ||
| − | + | DSP14 is a subfamily emerged in eumetazoan and duplicated in vertebrates. Human has four members, DUSP14 (MKP6), DUSP18, DUSP21 and DUSP28. Little is known about their functions. | |
=== Evolution === | === Evolution === | ||
| − | + | DSP14 subfamily emerged in eumetazoan and duplicated in vertebrates. | |
=== Domain === | === Domain === | ||
| − | + | DSP14 subfamily has a single phosphatase domain. | |
=== Function === | === Function === | ||
| + | DUSP14 (MKP6) dephosphorylates TGF-beta-activated kinase 1 (TAK1), a member of MAPKKK, at Thr-187 within its kinase activation loop. Thus, DUSP14 negatively regulates TNF- or IL-1-induced NF-kappaB activation <cite>Zheng13</cite>. DUSP14 is widely expressed in different tissues with highest expression in skin tissues (see [http://www.gtexportal.org/home/gene/DUSP14 GTEx]). | ||
| + | DUSP18 interacts with and dephosphorylates SAPK/JNK in vitro and in vivo. It does not dephosphorylate p38 or ERK1 <cite>Wu06</cite>. USP18 was widely expressed in different tissues as evidenced by RT-PCR <cite>Wu03</cite>. RNA-seq from [http://www.gtexportal.org/home/gene/DUSP18 GTEx] shows a high expression in testis and pituitary, and a low expression in skeleton. | ||
| + | |||
| + | DUSP21 plays an important role in sustaining human hepatocellular carcinoma cell proliferation <cite>Deng14</cite>. | ||
| + | |||
| + | DUSP28 is widely expressed in different tissues according to RNA-seq data from [http://www.gtexportal.org/home/gene/DUSP28 GTEx], but its function is unknown. | ||
=== References === | === References === | ||
<biblio> | <biblio> | ||
| − | + | #Deng14 pmid=23929653 | |
| + | #Wu03 pmid=12591617 | ||
| + | #Wu06 pmid=16720344 | ||
| + | #Zheng13 pmid=23229544 | ||
</biblio> | </biblio> | ||
Revision as of 02:36, 8 March 2015
Phosphatase Classification: Fold CC1: Superfamily CC1: Family DSP: Subfamily DSP14
DSP14 is a subfamily emerged in eumetazoan and duplicated in vertebrates. Human has four members, DUSP14 (MKP6), DUSP18, DUSP21 and DUSP28. Little is known about their functions.
Evolution
DSP14 subfamily emerged in eumetazoan and duplicated in vertebrates.
Domain
DSP14 subfamily has a single phosphatase domain.
Function
DUSP14 (MKP6) dephosphorylates TGF-beta-activated kinase 1 (TAK1), a member of MAPKKK, at Thr-187 within its kinase activation loop. Thus, DUSP14 negatively regulates TNF- or IL-1-induced NF-kappaB activation [1]. DUSP14 is widely expressed in different tissues with highest expression in skin tissues (see GTEx).
DUSP18 interacts with and dephosphorylates SAPK/JNK in vitro and in vivo. It does not dephosphorylate p38 or ERK1 [2]. USP18 was widely expressed in different tissues as evidenced by RT-PCR [3]. RNA-seq from GTEx shows a high expression in testis and pituitary, and a low expression in skeleton.
DUSP21 plays an important role in sustaining human hepatocellular carcinoma cell proliferation [4].
DUSP28 is widely expressed in different tissues according to RNA-seq data from GTEx, but its function is unknown.
References
Error fetching PMID 12591617:
Error fetching PMID 16720344:
Error fetching PMID 23229544:
- Error fetching PMID 23229544:
- Error fetching PMID 16720344:
- Error fetching PMID 12591617:
- Error fetching PMID 23929653:
