Difference between revisions of "Phosphatase Subfamily PTPRC"
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===Functions=== | ===Functions=== | ||
CD45 modulates immune function <cite>furlan14</cite>. It is selectively expressed on lymphocytes and dephosphorylates and activates the [http://kinase.com/wiki/index.php/Kinase_Family_Src src family] tyrosine kinases lck, fyn and lyn in B and T cells. | CD45 modulates immune function <cite>furlan14</cite>. It is selectively expressed on lymphocytes and dephosphorylates and activates the [http://kinase.com/wiki/index.php/Kinase_Family_Src src family] tyrosine kinases lck, fyn and lyn in B and T cells. | ||
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| + | === Miscellaneous === | ||
| + | PTPRC (CD45) is used in [http://en.wikipedia.org/wiki/Circulating_tumor_cell#CellSearch_Method CellSearch] system to detect [http://en.wikipedia.org/wiki/Circulating_tumor_cell circulating tumor cell]. | ||
===References=== | ===References=== | ||
Revision as of 18:05, 26 March 2015
Phosphatase Classification: Fold CC1: Superfamily CC1: Family PTP: Subfamily PTPRC
PTPRC (CD45) is a vertebrate-specific receptor PTP involved in immune signaling.
Evolution
PTPRC is found as a single-copy gene in all vertebrates, including the lamprey, but not in any invertebrate.
Domain
PTPRC has twin intracellular PTP phosphatase domains, and extracellular FN3 domains, plus a CD45-specific and a PTP-N-terminal domain found specifically in PTPRC, as annotated by InterPro. CD45 is extensively alternatively spliced.
Functions
CD45 modulates immune function [1]. It is selectively expressed on lymphocytes and dephosphorylates and activates the src family tyrosine kinases lck, fyn and lyn in B and T cells.
Miscellaneous
PTPRC (CD45) is used in CellSearch system to detect circulating tumor cell.
