Difference between revisions of "Phosphatase Subamily Paladin"

Revision as of 21:53, 14 April 2015

Phosphatase Classification: Fold CC1: Superfamily CC1: Family Paladin: [[Phosphatase_Subamily_Paladin|subfamily Paladin]

Evolution

Paladins are found in vertebrates and early metazoa such as sponge, trichoplax and nematostella but absent from arthropoda and nematoda. Paladins are also found in most plants and a small number of fungi (see internal database gOrtholog).

Domain

The Paladin subfamily has a single domain, which lacks the cysteine residue at Cx5R catalytic motif common among CC1-fold phosphatases.

Function

Little is known about Paladin's molecular function. It regulates phosphorylation status in neural crest cell formation and migration in chicken [1], but it lacks the residue necessary for phosphatase activity.

References

1. Roffers-Agarwal J, Hutt KJ, and Gammill LS. Paladin is an antiphosphatase that regulates neural crest cell formation and migration. Dev Biol. 2012 Nov 15;371(2):180-90. DOI:10.1016/j.ydbio.2012.08.007 | PubMed ID:22926139 | HubMed [Roffers-Agarwal12]