Difference between revisions of "Phosphatase Subfamily INPP5F"
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=== Function === | === Function === | ||
| − | Human INPP5F (SAC2) is expressed in most tissues and particularly abundant in brain (see [http://www.gtexportal.org/home/gene/INPP5F GTEx]). It has 5-phosphatase activity specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate <cite>Minagawa01</cite>. | + | Human INPP5F (SAC2) is expressed in most tissues and particularly abundant in brain (see [http://www.gtexportal.org/home/gene/INPP5F GTEx]). It has 5-phosphatase activity specific for phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3)<cite>Minagawa01</cite>. It also has 4-phosphatase activity toward PI(4,5)P2) in the endocytic pathway <cite>Nakatsu15, Hsu15</cite>. It cooperates with OCRL, a 5-phosphatase, in the sequential dephosphorylation of PI(4,5)P2 at the 4 and 5 position of inositol in a partnership that mimics that of the two phosphatase modules of synaptojanin <cite>Nakatsu15</cite>. |
=== References === | === References === | ||
<biblio> | <biblio> | ||
| + | #Hsu15 pmid=25869669 | ||
| + | #Minagawa01 pmid=11274189 | ||
| + | #Nakatsu15 pmid=25869668 | ||
</biblio> | </biblio> | ||
Revision as of 21:06, 15 April 2015
Phosphatase Classification: Fold CC1: Superfamily CC1: Family Sac: Subfamily INPP5F (SAC2)
Evolution
The INPP5F (SAC2) subfamily is found in most metazoa and fungi. It is also found in a few plants and basal eukaryotes (see gOrtholog database (internal)).
Domain
The INPP5F (SAC2) subfamily has a single structural domain, SAC phosphatase domain.
Function
Human INPP5F (SAC2) is expressed in most tissues and particularly abundant in brain (see GTEx). It has 5-phosphatase activity specific for phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3)[1]. It also has 4-phosphatase activity toward PI(4,5)P2) in the endocytic pathway [2, 3]. It cooperates with OCRL, a 5-phosphatase, in the sequential dephosphorylation of PI(4,5)P2 at the 4 and 5 position of inositol in a partnership that mimics that of the two phosphatase modules of synaptojanin [2].
References
- Minagawa T, Ijuin T, Mochizuki Y, and Takenawa T. Identification and characterization of a sac domain-containing phosphoinositide 5-phosphatase. J Biol Chem. 2001 Jun 22;276(25):22011-5. DOI:10.1074/jbc.M101579200 |
- Nakatsu F, Messa M, Nández R, Czapla H, Zou Y, Strittmatter SM, and De Camilli P. Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway. J Cell Biol. 2015 Apr 13;209(1):85-95. DOI:10.1083/jcb.201409064 |
- Hsu F, Hu F, and Mao Y. Spatiotemporal control of phosphatidylinositol 4-phosphate by Sac2 regulates endocytic recycling. J Cell Biol. 2015 Apr 13;209(1):97-110. DOI:10.1083/jcb.201408027 |
