Difference between revisions of "Phosphatase Subfamily INPP5F"

Revision as of 03:38, 16 April 2015

Phosphatase Classification: Fold CC1: Superfamily CC1: Family Sac: Subfamily INPP5F (SAC2)

INPP5F (SAC2) is a phosphoinositide phosphatase in the endocytic pathway. It is conserved in metazoa and fungi and is also found in a few plants and basal eukaryotes.

Evolution

The INPP5F (SAC2) subfamily is found in most metazoa and fungi. It is also found in a few plants and basal eukaryotes (see gOrtholog database (internal)).

Domain

The INPP5F (SAC2) subfamily has two structural domain, SAC phosphatase domain and 5-phosphatase domain. It also has a C-terminal proline-rich region [1].

Function

Human INPP5F (SAC2) is expressed in most tissues and particularly abundant in brain (see GTEx). It has 5-phosphatase activity specific for phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3)[2]. It also has 4-phosphatase activity toward PI(4,5)P2) in the endocytic pathway [3, 4]. It cooperates with OCRL, a 5-phosphatase, in the sequential dephosphorylation of PI(4,5)P2 at the 4 and 5 position of inositol in a partnership that mimics that of the two phosphatase modules of synaptojanin [3].

References

1. Error fetching PMID 10947947: [Hughes00]
2. Error fetching PMID 11274189: [Minagawa01]
3. Error fetching PMID 25869668: [Nakatsu15]
4. Error fetching PMID 25869669: [Hsu15]