Difference between revisions of "Phosphatase Subfamily PRL"
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=== Function === | === Function === | ||
| − | PRL is short for Phosphatases of Regenerating Liver. There are three PRLs in human, PRL1, PRL2, PRL3, all of which have been identified as key contributors to metastasis in several human cancers <cite>tremblay14 Von-Hoff06</cite>. The molecular mechanisms of PRL phosphatases is reviewed at here <cite>kohn12</cite> in 2012, but it may play other roles as more works are going-on | + | PRL is short for Phosphatases of Regenerating Liver. There are three PRLs in human, PRL1, PRL2, PRL3, all of which have been identified as key contributors to metastasis in several human cancers <cite>tremblay14, Von-Hoff06</cite>. The molecular mechanisms of PRL phosphatases is reviewed at here <cite>kohn12</cite> in 2012, but it may play other roles as more works are going-on. For example. deletion of PRL3 reduces clonogenicity and tumor-initiation ability of colitis-associated cancer cells in mice <cite>Cramer15</cite>. |
=== References === | === References === | ||
Revision as of 14:01, 23 April 2015
Phosphatase Classification: Fold CC1: Superfamily CC1: Family DSP: Subfamily PRL
Evolution
PRL subfamily is present in animals, amoeba, and many basal eukaryotes, but is absent from fungi and plants (unpublish data from gOrtholog).
Domain
PRL has a single domain: phosphatase domain.
Function
PRL is short for Phosphatases of Regenerating Liver. There are three PRLs in human, PRL1, PRL2, PRL3, all of which have been identified as key contributors to metastasis in several human cancers [1, 2]. The molecular mechanisms of PRL phosphatases is reviewed at here [3] in 2012, but it may play other roles as more works are going-on. For example. deletion of PRL3 reduces clonogenicity and tumor-initiation ability of colitis-associated cancer cells in mice [4].
References
Error fetching PMID 16275986:
Error fetching PMID 24632616:
Error fetching PMID 22413991:
Error fetching PMID 24632616:
Error fetching PMID 22413991:
- Error fetching PMID 24632616:
- Error fetching PMID 16275986:
- Error fetching PMID 22413991:
