Difference between revisions of "Phosphatase Subfamily DSP10"
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=== Evolution === | === Evolution === | ||
| − | DSP10 (MKP5) subfamily is found in most | + | DSP10 (MKP5) subfamily is found in most [holozoa] except nematodes. DSP10 is usually one copy per genome, e.g. DUSP10 (MKP5) in human. |
=== Domain === | === Domain === | ||
Revision as of 21:53, 12 May 2015
Phosphatase Classification: Fold CC1: Superfamily CC1: Family DSP: Subfamily DSP10 (MKP5)
DSP10 selectively dephosphorylates p38 and JNK. It is conserved across holozoan but lost in nematodes.
Evolution
DSP10 (MKP5) subfamily is found in most [holozoa] except nematodes. DSP10 is usually one copy per genome, e.g. DUSP10 (MKP5) in human.
Domain
DSP10 has two domains: rhodanese domain and phosphatase domain. Rhodanese domain can bind to kinases [1].
Function
DUSP10 is phosphatase specific for p38 and SAPK/JNK. It binds to p38 and SAPK/JNK, but not to MAPK/ERK, and inactivates p38 and SAPK/JNK, but not MAPK/ERK. p38 is a preferred substrate. It is present evenly in both the cytoplasm and the nucleus. DUSP10 is widely expressed in various tissues and organs, and its expression in cultured cells is elevated by stress stimuli [2, 3, 4].
On the other hand, it has been reported that DUSP10 interacts with ERK, retains it in the cytoplasm, suppresses its activation and downregulates ERK-dependent transcription [5].
Human DUSP10 is frequently upregulated in colorectal cancer (CRC). Certain mutations in DUSP10 correlate with the incidence of CRC. DUSP10/MKP5 also negatively regulates intestinal epithelial cell growth [6].
DUSP10/MKP5 is involved in immune system. It interacts with and dephosphorylates IRF3. Our study reveals a critical function of a DUSP in negative regulation of IRF3 activity and demonstrates a mechanism by which influenza and other RNA viruses inhibit type I interferon response in the host through MKP5.
DUSP10/MKP5 is implicated in immune system. It functions in the type I interferon system responding to viral infection. It interacts with, dephosphorylates and inactivates Interferon regulatory factor 3 (IRF3), an interferon regulatory factor which plays an important role in the type I interferon system. Increased type I interferon responses were observed in DUSP10/MKP5-deficient cells and animals upon various RNA virus infection, including H1N1 influenza virus, vesicular stomatitis virus and sendai virus [7]. DUSP10/MKP5 also regulates adipose tissue inflammation and insulin resistance [8].
References
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- Error fetching PMID 17400920:
- Error fetching PMID 10391943:
- Error fetching PMID 10597297:
- Error fetching PMID 16806267:
- Error fetching PMID 22711061:
- Error fetching PMID 25772234:
- Error fetching PMID 25772359:
- Error fetching PMID 25922079:
