Difference between revisions of "Phosphatase Subfamily DSP14"
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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_DSP|Family DSP]]: [[Phosphatase_Subfamily_DSP14|Subfamily DSP14]] | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_DSP|Family DSP]]: [[Phosphatase_Subfamily_DSP14|Subfamily DSP14]] | ||
| − | + | Eumetazoan-specific subfamily acting on MAPK cascade. | |
=== Evolution === | === Evolution === | ||
| − | DSP14 | + | DSP14 emerged in [[eumetazoa]] and duplicated in vertebrates, giving rise to four human members: DUSP14 (MKP6), DUSP18, DUSP21 and DUSP28. |
=== Domain === | === Domain === | ||
Revision as of 00:27, 13 May 2015
Phosphatase Classification: Fold CC1: Superfamily CC1: Family DSP: Subfamily DSP14
Eumetazoan-specific subfamily acting on MAPK cascade.
Evolution
DSP14 emerged in eumetazoa and duplicated in vertebrates, giving rise to four human members: DUSP14 (MKP6), DUSP18, DUSP21 and DUSP28.
Domain
DSP14 subfamily has a single phosphatase domain.
Function
DUSP14 (MKP6) dephosphorylates TGF-beta-activated kinase 1 (TAK1), a member of MAPKKK, at Thr-187 within its kinase activation loop. Thus, DUSP14 negatively regulates TNF- or IL-1-induced NF-kappaB activation [1]. DUSP14 is widely expressed in different tissues with highest expression in skin tissues (see GTEx).
DUSP18 interacts with and dephosphorylates SAPK/JNK in vitro and in vivo. It does not dephosphorylate p38 or ERK1 [2]. USP18 was widely expressed in different tissues as evidenced by RT-PCR [3]. RNA-seq from GTEx shows a high expression in testis and pituitary, and a low expression in skeleton.
DUSP21 plays an important role in sustaining human hepatocellular carcinoma cell proliferation [4].
DUSP28 (VHP) is widely expressed in different tissues according to RNA-seq data from GTEx, but its function is unknown.
References
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