Difference between revisions of "Phosphatase Subfamily PRL"
(→References) |
|||
| Line 1: | Line 1: | ||
__NOTOC__ | __NOTOC__ | ||
| − | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_DSP|Family DSP]]: [[Phosphatase_Subfamily_PRL|Subfamily PRL]] | + | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_DSP|Family DSP]]: [[Phosphatase_Subfamily_PRL|Subfamily PRL]] (PTP4A) |
| − | + | ||
| − | + | ||
=== Evolution === | === Evolution === | ||
| Line 11: | Line 9: | ||
=== Function === | === Function === | ||
| − | PRL is short for Phosphatases of Regenerating Liver. There are three PRLs in human, PRL1, PRL2, PRL3, all of which have been identified as key contributors to metastasis in several human cancers <cite>tremblay14, Von-Hoff06</cite>. The molecular mechanisms of PRL phosphatases is reviewed at here <cite>kohn12</cite> in 2012 | + | PRL is short for Phosphatases of Regenerating Liver. There are three PRLs in human, PRL1, PRL2, PRL3, all of which have been identified as key contributors to metastasis in several human cancers <cite>tremblay14, Von-Hoff06</cite>. The molecular mechanisms of PRL phosphatases is reviewed at here <cite>kohn12</cite> in 2012. |
| + | |||
| + | PRL3 is implicated in cancer. For instance, deletion of PRL3 reduces clonogenicity and tumor-initiation ability of colitis-associated cancer cells in mice <cite>Cramer15</cite>. PRL3 (PTP4A3) independently predicts metastasis and survival in upper tract urothelial carcinoma treated with radical nephroureterectomy <cite></cite>. | ||
=== References === | === References === | ||
| Line 19: | Line 19: | ||
#tremblay14 pmid=24632616 | #tremblay14 pmid=24632616 | ||
#kohn12 pmid=22413991 | #kohn12 pmid=22413991 | ||
| + | #Yeh15 pmid=26070892 | ||
</biblio> | </biblio> | ||
Revision as of 18:25, 15 June 2015
Phosphatase Classification: Fold CC1: Superfamily CC1: Family DSP: Subfamily PRL (PTP4A)
Evolution
PRL subfamily is present in animals, amoeba, and many basal eukaryotes, but is absent from fungi and plants (unpublish data from gOrtholog).
Domain
PRL has a single domain: phosphatase domain.
Function
PRL is short for Phosphatases of Regenerating Liver. There are three PRLs in human, PRL1, PRL2, PRL3, all of which have been identified as key contributors to metastasis in several human cancers [1, 2]. The molecular mechanisms of PRL phosphatases is reviewed at here [3] in 2012.
PRL3 is implicated in cancer. For instance, deletion of PRL3 reduces clonogenicity and tumor-initiation ability of colitis-associated cancer cells in mice [4]. PRL3 (PTP4A3) independently predicts metastasis and survival in upper tract urothelial carcinoma treated with radical nephroureterectomy [].
References
Error fetching PMID 16275986:
Error fetching PMID 24632616:
Error fetching PMID 22413991:
Error fetching PMID 26070892:
- Error fetching PMID 24632616:
- Error fetching PMID 16275986:
- Error fetching PMID 22413991:
- Error fetching PMID 24950307:
- Error fetching PMID 26070892:
