Difference between revisions of "Phosphatase Family OCA"

Revision as of 19:35, 14 August 2016

Phosphatase Classification: Fold CC1: Superfamily CC1: Family OCA

The OCA family is named after the five member genes in yeast (OCA1-5 = Oxidant-induced Cell-cycle Arrest). The family is also called plant and fungi atypical (PFA)-DSPs [1, 2].

Evolution

The OCA family is found in many eukaryotes, including fungi, plants, protists, choanoflagellates (Monosiga), and sponge. It is absent from most eumetazoa, but is found in several invertebrate deuterostomes (the urchin (Strongylocentrotus purpuratus), lancelet (Branchiostoma floridae)) and even an early-branching vertebrate, the ghostshark (Callorhinchus milii) and a few protostomes: Capitella teleta, the owl limpet (Lottia gigantea), and the leech (Helobdella robusta).

Domain

OCA has a single domain, a phosphatase domain of fold CC1.

Functions

Yeast OCA members are involved in cell cycle arrest in response to oxidative damage[3], in telomere capping [4], in actin organization [5]. OCA3 has been shown to control intracellular localization of Gln3 (a phosphorylated transcriptional activator), in cooperation with Npr1 kinase [6].

References

1. Error fetching PMID 17976645: [Pulido07]
2. Error fetching PMID 21409566: [Pulido11]
3. Error fetching PMID 11408586: [Alic]
4. Error fetching PMID 18845848: [lydall08]
5. Error fetching PMID 15020461: [Care]
6. Error fetching PMID 18166280: [Harashima08]