Difference between revisions of "Phosphatase Subfamily egg"
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=== Function === | === Function === | ||
| − | + | All three ''C. elegans'' members are predicted to be catalytically inactive, due to loss of the cysteine and/or arginine of the Cx5R motif. egg-4 and egg-5 control the oocyte- to-zygote transition by regulating signaling by the DYRK family kinase MBK-2. egg-4/egg-5 binds to MBK-2 at the substrate-binding groove of the kinase, and inhibits the ability of the kinase to bind and phosphorylate substrates, thereby inhibiting downstream signaling <cite> Cheng09 , Parry09, Tonks09 </cite>. | |
=== References === | === References === | ||
Revision as of 21:12, 7 September 2016
Phosphatase Classification: Fold CC1: Superfamily CC1: Family PTP: Subfamily Egg
Evolution
The eak subfamily is nematode specific. C. elegans has three members: egg-3, egg-4, egg-5.
Domain
The egg subfamily has a single structural domain: the phosphatase domain of CC1 fold.
Function
All three C. elegans members are predicted to be catalytically inactive, due to loss of the cysteine and/or arginine of the Cx5R motif. egg-4 and egg-5 control the oocyte- to-zygote transition by regulating signaling by the DYRK family kinase MBK-2. egg-4/egg-5 binds to MBK-2 at the substrate-binding groove of the kinase, and inhibits the ability of the kinase to bind and phosphorylate substrates, thereby inhibiting downstream signaling [1, 2, 3].
References
Error fetching PMID 19879842:
Error fetching PMID 19879147:
Error fetching PMID 19879835:
Error fetching PMID 19879147:
Error fetching PMID 19879835:
- Error fetching PMID 19879842:
- Error fetching PMID 19879147:
- Error fetching PMID 19879835:
