Difference between revisions of "Phosphatase Family HP2"

Revision as of 16:27, 17 June 2014

Phosphatase Classification: Histidine phosphatase superfamily: HP, branch2 family

One subfamily in this family has been reported as protein phosphatases. See Pfam ID PF00328 for general information.

ACPP

ACPP (acid phosphatase, prostate) is a prostate epithelium-specific differentiation antigen, and is decreased in prostate carcinomas. It has been show to downregulate prostate cell growth by dephosphorylating phosphotyrosine on c-ErbB-2, an oncoprotein in prostate cells [1]. His-12 and Asp-258 of ACPP, but not Cys-183 or Cys-281, are required for the phosphatase activity [2]. ACPP and its paralog ACP2 is found in metazoan, choanoflagellida, amoebozoa and some protists, but is absent from fungi and plants.

References

1. Error fetching PMID 9705354: [ACPP_2]
2. Error fetching PMID 11067847: [ACPP_1]