Difference between revisions of "Phosphatase Family Myotubularin"
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| − | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_Myotubularin|Myotubularin]] | + | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|FoldCC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_Myotubularin|Myotubularin]] |
| − | Myotubularins are 3-phosphatases specific for PtdIns3P and PtdIns(3,5)P2, two PIs that function within the endosomal-lysomal pathway . In yeast, there is a single myotubularin Ymr1p, and its functions appear to be redundant with those of other 3-phosphatases. | + | Myotubularins are 3-phosphatases specific for PtdIns3P and PtdIns(3,5)P2, two PIs that function within the endosomal-lysomal pathway . In yeast, there is a single myotubularin Ymr1p, and its functions appear to be redundant with those of other 3-phosphatases. In C. elegans, which has six myotubularins, several of the myotublarins have non-redundant roles in regulating PtdIns3P during endocytosis. In human, there are 14 myotublarins, and mutations in several of them lead to myotubular myopathy and Charcot-Marie-Tooth peripheral neuropathy. Interestingly, around half of myotubularins are catalytically inactive. One of their possible function is regulating active myotubularins by protein interaction. For details, see the review <cite>Robinson06</cite>. |
== Subfamilies == | == Subfamilies == | ||
| − | ===== MTMR1 | + | ===== [[Phosphatase_Subfamily_MTMR1|MTMR1]]===== |
===== MTMR3 subfamily ===== | ===== MTMR3 subfamily ===== | ||
Revision as of 16:33, 30 December 2014
Phosphatase Classification: FoldCC1: Superfamily CC1: Myotubularin
Myotubularins are 3-phosphatases specific for PtdIns3P and PtdIns(3,5)P2, two PIs that function within the endosomal-lysomal pathway . In yeast, there is a single myotubularin Ymr1p, and its functions appear to be redundant with those of other 3-phosphatases. In C. elegans, which has six myotubularins, several of the myotublarins have non-redundant roles in regulating PtdIns3P during endocytosis. In human, there are 14 myotublarins, and mutations in several of them lead to myotubular myopathy and Charcot-Marie-Tooth peripheral neuropathy. Interestingly, around half of myotubularins are catalytically inactive. One of their possible function is regulating active myotubularins by protein interaction. For details, see the review [1].
Contents
Subfamilies
MTMR1
MTMR3 subfamily
MTMR5 subfamily
Inactive myotubularin subfamily.
MTMR1 subfamily
MTMR9 subfamily
MTMR10 subfamily
MTMR14 subfamily
C2-MTMR1 subfamily
The feature of this subfamily is a C2 domain attached to the R1-like sequence.
