Difference between revisions of "Phosphatase Subfamily MTMR1"

Revision as of 16:40, 30 December 2014

Phosphatase Classification: FoldCC1: Superfamily CC1: Family Myotubularin

CTDSPL2 (CTD small phosphatase like 2) is a poorly-studied RNA polymerase CTD phosphatase which is found in most eukaryotes.

Evolution

CTDSPL2 is found as a single copy gene in most eukaryotes. It is absent from all but a few basal fungi, and is also lost in Drosophilids. The human gene is called CTSDPL2, HSPC058, HSPC129, or SCP4

Domain Structure

Usually a C-terminal phosphatase domain with a relatively poorly conserved N-terminal extension

Catalytic activity

Human CTDSPL2 has experimentally-shown activity [1] and orthologs are also predicted to be active.

Functions

Human CTDSPL2 binds and dephosphorylates Smad1/5/8, and attenuates signaling through the BMP pathway [2]

Related Kinases

See Phosphorylation of RNA polymerase II C-terminal domain.

References

1. Error fetching PMID 17487459: [qian]
2. Error fetching PMID 25100727: [Zhao]