Phosphatase Subfamily PTPRK

Phosphatase Classification: Fold CC1:Superfamily CC1: Family PTP: Subfamily PTPRK

PTPRG is a receptor PTP family involved in metazoan neural development and maybe cancer.

Evolution

PTPRK subfamily is vertebrate specific. There are four copies in human.

Domain Structure

PTPRK has dual intracellular catalytic domains. The canonical extracellular domain combination is a MAM domain, Ig domain and multiple FN3 domain.

MAM domain is essential for homophilic cell-cell interaction and helps determine the specificity of these interactions. Truncated PTPRM is properly expressed at the cell surface but fails to promote cell-cell adhesion. Homophilic cell adhesion is fully restored in a chimeric PTPRM molecule containing the MAM domain of PTPRK. However, this chimeric RPTP mu does not interact with either PTPRK or PTPRM [1].

Functions

PTPRK and PTPRM mediates homophilic cell-cell interaction [1, 2].

PTPRK

Putative tumor suppressor [3].

PTPRK regulates CD4+ T cell development through ERK1/2-mediated signaling [4].

References

Error fetching PMID 8264577:
Error fetching PMID 7782276:
Error fetching PMID 9722959:
Error fetching PMID 19800317: