Phosphatase Subfamily LHPP
Phosphatase Classification: Fold HAD: Superfamily HAD: Family NagD: Subfamily LHPP
LHPP is a protein histidine phosphatase conserved in holozoan.
Evolution
LHPP is found across holozoa. Distinct HDHD2 and LHPP genes are found as single copies in most animals, though Drosophila lacks LHPP and Sea Urchin has a HDHD2 pseudogene with frameshift. Several fungi and oomycetes also have HDHD2-like genes. HDHD2-like genes are also found in a small number of bacteria.
Domain
LHPP subfamily has a single domain, HAD domain.
Function
LHPP (lysine histidine pyrophosphate phosphatase) from cow was shown to dephosphorylate succinic thiokinase and nucleoside diphosphate kinase autophosphorylated at His residues. LHPP also has activity against free phospho-lysine and phospho-histidine amino acids [1]. HDHD2 (Haloacid Dehalogenase-like Hydrolase Domain containing 2) is conserved in most animals but has not been experimentally studied.
